A5059862677- Lipid Membrane Structure and Behavior
- Nanoparticle-Based Drug Delivery
- Protein Interaction Studies and Fluorescence Analysis
- Antibiotic Resistance in Bacteria
- Spectroscopy and Quantum Chemical Studies
- Advancements in Transdermal Drug Delivery
- Bacteriophages and microbial interactions
- Nanoplatforms for cancer theranostics
- Bacterial biofilms and quorum sensing
- Glioma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Sphingolipid Metabolism and Signaling
IPO Porto
2025
Universidade do Porto
2017-2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2025
Rede de Química e Tecnologia
2017-2023
Google (United States)
2017
Despite doxorubicin being commonly used in chemotherapy there still remain significant holes our knowledge regarding its delivery efficacy and an observed resistance mechanism that is postulated to involve the cell membrane. One possible efflux by protein P-gp, which found predominantly cholesterol enriched domains. Thereby, a hypothesis for vulnerability of through P-gp enhanced affinity ordered rich regions plasma Thus, we have studied doxorubicin's interaction with model membranes rich,...
Daunorubicin is extensively used in chemotherapy for diverse types of cancer. Over the years, evidence has suggested that mechanisms by which daunorubicin causes cytotoxic effects are also associated with interactions at membrane level. The aim present work was to study interplay between and mimetic models composed different ratios 1,2-dimyristoyl- sn -glycero- 3 -phosphocholine (DMPC), sphingomyelin (SM) cholesterol (Chol). Several biophysical parameters were assessed using liposomes as...
There is a growing need for alternatives to target and treat bacterial infection. Thus, the present work aims develop optimize production of PEGylated magnetoliposomes (MLPs@PEG), by encapsulating superparamagnetic iron oxide nanoparticles (SPIONs) within fusogenic liposomes. A Box–Behnken design was applied modulate size distribution variables, using lipid concentration, SPIONs amount ultrasonication time as independent variables. As result optimization, it possible obtain MLPs@PEG with...