A5050246298- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Central Venous Catheters and Hemodialysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Neutropenia and Cancer Infections
- Nutrition and Health in Aging
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Folate and B Vitamins Research
- Bone and Joint Diseases
- Adolescent and Pediatric Healthcare
- Blood disorders and treatments
- Neonatal Respiratory Health Research
- Pericarditis and Cardiac Tamponade
- Metabolism and Genetic Disorders
- Vascular Tumors and Angiosarcomas
Army Hospital Research and Referral
2019-2025
Pediatrics and Genetics
2020-2024
Sri Devaraj Urs Medical College
2023
Command Hospital
2023
Creative Commons
2023
Shri Venkateshwara University
2023
Institute of Medical Sciences
2023
Eastern Command Hospital
2023
Post Graduate Institute of Medical Education and Research
2016-2018
Military Hospital
2011-2014
Central nervous system (CNS) manifestations are seen in two-thirds cases of familial haemophagocytic lymphohistiocytosis (HLH). Isolated CNS-HLH is described as a rare entity characterised by isolated neuroinflammation without fulfilling diagnostic criteria for evidence systemic inflammation mutation-proven HLH due to additional genetic modifiers. We describe one such female preschooler who presented us with the fever unknown origin spanning over year and was dilemma. Only two out available...
Myeloid neoplasm post-cytotoxic therapy (MN-pCT) includes acute myeloid leukaemia (AML) arising in patients exposed to cytotoxic or radiation for unrelated conditions. MN-pCT is rare children and generally has a poor outcome. Mixed lineage locus translocations (MLL/KMT2A) are the most common cytogenetic abnormalities associated with topoisomerase-II inhibitor exposure MN-pCT. v-raf murine sarcoma viral oncogene homolog B1 (BRAF) targetable mutations seen <1% of de novo AML, but prognosis....
The standard practice during high-dose methotrexate (HD-MTX) in acute lymphoblastic leukemia (ALL) to mitigate toxicity is serially monitor levels till serum MTX < 0.01 μmol/L. Most resource-limited centers lack in-house access levels, and therefore repeated monitoring costly cumbersome. We studied the efficacy safety of "solitary 36 hours post HD-MTX (MTX36 )."This prospective observational study consecutively enrolled children with ALL receiving HD-MTX. Cycles unavailable MTX36 > 10 μmol/L...
Abstract Background The standard practice to mitigate high‐dose methotrexate (HD‐MTX)–induced nephrotoxicity (HMN) in acute lymphoblastic leukemia (ALL) is monitor levels until serum MTX falls below a predefined threshold. It not feasible most resource‐constrained centers. Literature on the various factors affecting HMN these centers limited, retrospective, and heterogeneous. Though hypoalbuminemia has been postulated as risk factor for HMN, relationship of undernutrition with studied....
Rare clinical conditions often are last to be excluded in real scenarios and sometimes produce surprising results. We would like present a case which presented diagnostic dilemma due confusing laboratory findings finally turned out rare genetic syndrome. A 3-year-old male child from Maharashtra was brought with short history of fever generalized weakness for the past 1 week. On examination, well developed age but showed pallor. The rest general systemic examination within normal limits....
Abstract Background Central venous access devices (CVAD) are vital for cancer therapeutics in pediatric oncology. Tunneled vascular (TVAD) preferred children prolonged and frequent access. Data on insertion, care, complications of CVAD from low middle‐income countries (LMIC) scarce, heterogeneous, retrospective. Procedure This prospective observational study eligible <12 years with malignancies requiring chemotherapy minimum 6 months diagnosis excluded mucosal bleeding, coagulopathy,...
Transcobalamin (TC) deficiency is a rare autosomal recessive inborn error of cobalamin transport which clinically manifests in early infancy. We describe child with TC who presented classical clinical and lab stigmata vitamin B 12 metabolism except normal serum levels. He was started on empirical parenteral supplements at 2 months age; however, the definitive diagnosis could only be established 6 years age when genetic evaluation revealed homozygous nonsense variation exon 8 TCN2 gene...
Acute myeloid leukemia (AML) is the commonest in adults. Mortality thew first 30-days ranges from 6% to 43%, while infections account for 30-66% of early deaths. We aim present our experience newly-diagnosed AML.This prospective, observational study, was undertaken at a tertiary care hospital Northern India. Patients with confirmed AML (bone marrow morphology and flow cytometry) who had developed febrile neutropenia (FN), were included.A total fifty-five patients included study. The median...