A5080049350- Mosquito-borne diseases and control
- HIV Research and Treatment
- Malaria Research and Control
- Synthesis and Characterization of Heterocyclic Compounds
- Water Quality Monitoring and Analysis
- interferon and immune responses
- Pesticide Residue Analysis and Safety
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Water Quality and Pollution Assessment
- Curcumin's Biomedical Applications
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Sensors
- Analytical Methods in Pharmaceuticals
- Synthesis and biological activity
- Rheumatoid Arthritis Research and Therapies
Siksha O Anusandhan University
2019-2024
Sambalpur University
2021
Context: Acetylsalicylic acid (ASA) has been repositioned against different inflammatory disease conditions. However, on long-term use, ASA is reported to cause hepatotoxicity by compromising the antioxidant status. Curcumin known for its and anti-inflammatory action. Accordingly, co-use of curcumin can be expected enhance effects while minimizing hepatotoxicity. Aims: To evaluate hepatoprotective when co-administered with ASA. Methods: activity carrageenan-induced paw edema cotton pellet...
Chikungunya virus (CHIKV) infection was previously found to be inhibited by MBZM-N-IBT both in vitro and vivo. To further assess its suitability for vivo application, toxicity pharmacokinetics were investigated. It showed no acute orally with an estimated LD50 of more than 5000 mg/kg rats. While it at 1000 the chronic study, better tolerated 500 At 50 mg/kg, safe a 9-month study. A pharmacokinetic study revealed Tmax less gastric emptying time. High plasma protein binding supported higher...
Introduction: Arthritis is the cause of morbidity associated with Chikungunya virus (CHIKV) infection. It persists even after has been cleared from body. MBZM-NIBT was earlier shown to inhibit infection in vitro and vivo. Objective: The objective this study determine ability MBZM-N-IBT manage arthritis independent CHIKV Methods: acute toxicity determined find a permissible oral dose. Effects against inflammation were relevant preclinical models. Network pharmacology used propose possible...
A simple, rapid, precise, and accurate high-performance liquid chromatography method was developed for simultaneous estimation of Clobetasol propionate Fusidic acid in cream. The separation obtained using a mobile phase consisting Acetonitrile Water the ratio 90:10 adjusting pH 5.0 with Glacial acetic (10%) Shim-pack solar C18 (250 × 4.6 mm, 5 μm) column. flow rate 1.0 mL/min UV detection at 240 nm employed. retention time 4.787 min 6.006 respectively. Linearity found to be range 3-7 μg/mL...
There is no approved antiviral for the management of Chikungunya virus (CHIKV). To develop an drug that can manage both CHIKV and arthritis induced by it, ester conjugate telmisartan (TM) salicylic acid (SA) was synthesized (DDABT1). It showed higher potency (IC50 14.53 μM) a good selectivity index [(SI = CC50/IC50) > 33]. On post-treatment DDABT1, infection inhibited significantly reducing CPE, viral titer, RNA, proteins. Further, time addition experiment revealed >95% inhibition up to 4hpi...
Pesticides have played a serious role in achieving the utmost crop production but maximum usage and accumulation of pesticide residues is very detrimental to aquatic other ecosystem. Pesticide water become major challenge over last few decades has been monitored public supply resources national capital territory. Results shows that continuous consumption contaminated can pose severe health threats local parts this area. Central Pollution Control Board (CPCB), Delhi, ? isomers endosulphan...