A5003562723- Circadian rhythm and melatonin
- Diet and metabolism studies
- Luminescence Properties of Advanced Materials
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Inorganic and Organometallic Chemistry
- Dietary Effects on Health
- Analytical Chemistry and Chromatography
- Adipose Tissue and Metabolism
- Molecular Sensors and Ion Detection
- Metal-Catalyzed Oxygenation Mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Cholesterol and Lipid Metabolism
- Ubiquitin and proteasome pathways
- Electrochemical sensors and biosensors
- Ga2O3 and related materials
- Photodynamic Therapy Research Studies
- Plant Molecular Biology Research
- Genetics, Aging, and Longevity in Model Organisms
- Synthesis of Tetrazole Derivatives
- Lipid metabolism and biosynthesis
Polish Academy of Sciences
2017-2021
Institute of Physics
2018-2021
University of Kansas Medical Center
2018-2020
In photodynamic therapy (PDT), photosensitizer (PS) molecules are irradiated by light to generate reactive oxygen species (ROS), the presence of which subsequently leads cell death. At present, modality is limited treatment skin diseases because low tissue penetration visible or ultraviolet required for producing ROS. To increase and extend therapeutic possibilities PDT deep-seated cancer, rare-earth doped nanoparticles capable up-converting infrared investigated. These (UCNPs) conjugated...
In this work we adapt rare-earth-ion-doped NaYF4nanoparticles coated with a silicon oxide shell (NaYF4:20%Yb,0.2%Tm@SiO2) for biological and medical applications (for example, imaging of cancer cells therapy at the nano level). The wide upconversion emission range under 980 nm excitation allows one to use nanoparticles cell (4T1) photodynamic (PDT) without photosensitizer. reactive oxygen species (ROS) are generated by Tm/Yb ion (blue UV light). Thein vitroPDT was tested on 4T1 incubated...
The circadian oscillator is a molecular feedback circuit whose orchestration involves posttranslational control of the activity and protein levels its components. Although controlled proteolysis proteins critical for function, our understanding underlying mechanisms remains incomplete. Here, we report that JmjC domain-containing 5 (JMJD5) interacts with CRYPTOCHROME 1 (CRY1) in an F-box/leucine-rich repeat 3 (FBXL3)-dependent manner facilitates targeting CRY1 to proteasome. Genetic deletion...
The liver is a key regulator of systemic energy homeostasis whose proper function dependent on the circadian clock. Here, we show that livers deficient in oscillator component JARID1a exhibit dysregulation genes involved metabolism. Importantly, find mice lack hepatic have decreased lean body mass, respiratory exchange ratios, faster production ketones, and increased glucose response to fasting. Finally, loss compromises transcriptome nutrient availability. In all, ablation disrupts...
Abstract The liver is a key regulator of systemic energy homeostasis whose proper function dependent on the circadian clock. Here, we show that livers deficient in oscillator component JARID1a exhibit dysregulation genes involved metabolism. Importantly, find mice lack hepatic have decreased lean body mass, respiratory exchange ratios, faster production ketones and increased glucose response to fasting. Finally, loss compromises transcriptome nutrient availability. In all, ablation disrupts...
The liver is a key regulator of systemic energy homeostasis whose proper function dependent on the circadian clock. Here, we show that livers deficient in oscillator component JARID1a exhibit dysregulation genes involved metabolism. Importantly, find mice lack hepatic have decreased lean body mass, respiratory exchange ratios, faster production ketones and increased glucose response to fasting. Finally, loss compromises transcriptome nutrient availability. In all, ablation disrupts...
Biological activity and molecular structure of two series electrochemically obtained Cu(II) complexes with tautomeric 1,5-disubstituted tetrazole derivatives (1-(2-fluorophenyl)-5-(4-methoxyanilino)-5H-tetrazol-1-ium 5-(2-fluoroanilino)-1-(4-methoxyphenyl)-5H-tetrazol-1-ium) were studied. In contrast to microbiological activity, promising selective antitumor against human metatstatic prostate cancer cell line (PC-3) was found. order simulate the cellular living environment, tested compounds...
The binding mechanism between Cu(II) ions and bioactive Schiff base derivative ligands, i.e., 2-[(4-methoxyphenylimino)metyl]phenol, 4,6-dichloro-2-[(4-hydroxyphenyl-imino)methyl]phenol 4,6-dichloro-2-[(4-methoxyphenylimino)methyl]phenol, in the form of non-crystalline complexes has been successfully studied using multi-technique methodology based on X-ray absorption fine structure spectroscopy.A distorted square planar geometry around composed two bidently coordinated ligands found for all...