A5026851862- Fish Ecology and Management Studies
- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Marine and fisheries research
- DNA Repair Mechanisms
- Nematode management and characterization studies
- Carcinogens and Genotoxicity Assessment
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Fish Biology and Ecology Studies
- Birth, Development, and Health
- Entomopathogenic Microorganisms in Pest Control
- Inorganic and Organometallic Chemistry
- Pregnancy and preeclampsia studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- X-ray Diffraction in Crystallography
- Antimicrobial Resistance in Staphylococcus
- Protein Kinase Regulation and GTPase Signaling
- Zebrafish Biomedical Research Applications
- Aquaculture disease management and microbiota
- Aquatic Invertebrate Ecology and Behavior
- Cancer therapeutics and mechanisms
- Crystallization and Solubility Studies
- Cancer, Hypoxia, and Metabolism
- Isotope Analysis in Ecology
University of East Anglia
2018-2024
Centre for Environment, Fisheries and Aquaculture Science
2022-2024
Google (United States)
2023
Norwich Research Park
2018-2021
AstraZeneca (United Kingdom)
2011-2017
Community Hospital
2016-2017
Merck & Co., Inc., Rahway, NJ, USA (United States)
2017
University of Glasgow
2013-2016
Wasser Cluster Lunz
2014
Oregon Health & Science University
2004-2013
The approval of bedaquiline to treat tuberculosis has validated adenosine triphosphate (ATP) synthase as an attractive target kill Mycobacterium (Mtb). Herein, we report the discovery two diverse lead series imidazo[1,2-a]pyridine ethers (IPE) and squaramides (SQA) inhibitors mycobacterial ATP synthesis. Through medicinal chemistry exploration, established a robust structure-activity relationship these scaffolds, resulting in nanomolar potencies synthesis inhibition assay. A biochemical...
Journal Article Post-traumatic thrombosis of the internal carotid and vertebral arteries after non-penetrating injuries neck Get access David S Murray Assistant Orthopædic Surgeon Falkirk Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Surgery, Volume 44, Issue 188, May 1957, Pages 556–561, https://doi.org/10.1002/bjs.18004418803 Published: 05 December 2005
An enantioselective synthesis of the potent anti-HIV nucleoside EFdA is presented. Key features stereocontrol include construction fully substituted 4′-carbon via a biocatalytic desymmetrization 2-hydroxy-2-((triisopropylsilyl)ethynyl)propane-1,3-diyl diacetate and Noyori-type asymmetric transfer hydrogenation to control stereochemistry 3′-hydroxyl bearing carbon. The discovery selective crystallization an N-silyl intermediate enabled isolation desired β-anomer from glycosylation step.
Climate change-related heatwaves are major threats to biodiversity and ecosystem functioning. However, our current understanding of the mechanisms governing community resistance recovery from extreme temperature events is still rudimentary. The spatial insurance hypothesis postulates that diverse regional species pools can buffer functioning against local disturbances through immigration better-adapted taxa. Yet, experimental evidence for such predictions multi-trophic communities pulse-type...
Using knowledge of the substrate specificity cPLA(2) (phospholipases A(2)), a novel series inhibitors this enzyme were designed based upon three point model inhibitor binding to active site comprising lipophilic anchor, an electrophilic serine "trap", and acidic moiety. The resulting 1,3-diheteroatom-substituted propan-2-ones evaluated as in both aggregated bilayer soluble assays. Systematic variation lipophilic, electrophilic, groups revealed well-defined structure-activity relationship...
The Staphylococcus aureus multidrug-binding protein QacR represses transcription of the plasmid-encoded membrane QacA, a multidrug efflux transporter. is induced by multiple structurally dissimilar monovalent and bivalent cationic lipophilic compounds, many which are effluxed from cell QacA via proton motive force. pocket has been shown to be quite extensive features several glutamates aromatic residues. To date, structure only one QacR-bivalent drug complex (that bound dequalinium)...
Abstract Dietary restriction in the form of fasting is a putative key to healthier and longer life, but these benefits may come at trade‐off with reproductive fitness affect following generation(s). The potential inter‐ transgenerational effects long‐term starvation are particularly poorly understood vertebrates when they originate from paternal line. We utilised externally fertilising zebrafish amenable split‐egg clutch design explore male‐specific fasting/starvation on fertility offspring...
Triploidy could prevent escaped farm salmon breeding in the wild, while also improving nutrient quality within farmed fillets. Despite these potential advantages, triploid Atlantic have not been widely used aquaculture, and their reproductive function has yet to be fully evaluated. Here, we compare fillet composition between diploid under standard aquaculture rearing conditions. We show that female triploids are sterile do develop gonads. By contrast, males produce large numbers of motile...
In this study, the relationships between cellular oxygen enhancement ratios (OER) and nucleotide excision repair capability were examined using UV20 mutant cell line (which has a defective ERCC1 gene). Using clonogenic survival assay, OER for killing of wild-type AA8 cells was 3.2 +/- 0.1, whereas that only 2. 35 +/_ 0.05; decreased result their significantly greater radiosensitivity relative to under hypoxic conditions. cells, hypoxia protected against DNA double-strand break (dsb)...
The current epoch in fisheries science has been driven by continual advances laboratory techniques and increasingly sophisticated approaches to analysing datasets. We now have the scientific knowledge tools proactively identify obstacles sustainable management of marine resources. However, addition technological advances, there are predicted global environmental changes, each with inherent implications for fisheries. 2023 symposium Fisheries Society British Isles called "open constructive...
Abstract Novel macrolactam and macroketone analogues of the migrastatin macrolide core have been synthesised from tri‐ O ‐acetyl‐ D ‐glucal in order to facilitate structure‐activity studies. The Horner olefination, followed by ring‐closing metathesis were key steps synthesis macroketone. ability derivatives inhibit migration gastric tumour cells as determined using a transwell assay compared with macrolactone dorrigocin A analogues. One congener was most potent inhibitor cancer cell...
This study examined the potential biochemical and mechanical structures that may contribute to egg adhesion in European whitefish Coregonus lavaretus. Experiments showed eggs from a population of C. lavaretus Loch Eck remained non-adhesive solution chemically similar ovarian fluid but became adhesive seconds after contact with water. Examination ultrastructure chorion morphology changed significantly water, nodule-like protuberances attached connective filaments on surface present...
ABSTRACT As the threat of climate change and associated heatwaves grows, we need to understand how natural populations will respond. Inter‐generational non‐genetic inheritance may play a key role in rapid adaptation, but whether such mechanisms are truly adaptive sufficient protect wild is unclear. The contribution paternal effects particular not fully understood, even though male reproductive system be highly sensitive heatwaves. We used zebrafish Danio rerio investigate on fertility assess...
The environment gametes perform in just before fertilization is increasingly recognized to affect offspring fitness, yet the contributions of male and female their adaptive significance remain largely unexplored. Here, we investigated gametic thermal plasticity its effects on hatching success embryo performance Atlantic salmon (Salmo salar). Eggs sperm were incubated overnight at 2°C or 8°C, temperatures within optimal range this species. Crosses between warm- cold-incubated compared using a...
Many fish species face increasing challenges associated with climate change and overfishing. At the same time, aquaculture is becoming vital for food security. Gaining a deeper understanding of basic biology therefore more important than ever. Here we synthesize summarize key questions, opportunities in highlighted during round‐table discussion at 50th Anniversary Symposium The Fisheries Society British Isles, held University Exeter, U.K., July 2017. We identified several knowledge gaps but...