Hakan Karaaslan

ORCID: 0000-0003-4766-769X
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About
Contact & Profiles
Research Areas
  • dental development and anomalies
  • Bone and Dental Protein Studies
  • Dental Trauma and Treatments
  • Molecular Biology Techniques and Applications
  • Paleopathology and ancient diseases
  • Forensic Anthropology and Bioarchaeology Studies
  • Dental Radiography and Imaging
  • Dental Erosion and Treatment
  • Dental materials and restorations
  • Endodontics and Root Canal Treatments
  • Pleistocene-Era Hominins and Archaeology

Harvard University
2023

Hacettepe University
2018-2020

New York University
2020

Excess albumin in enamel is a characteristic of the prevalent developmental dental defect known as chalky teeth or molar hypomineralization (MH). This study uses proteomic analyses pig to discern between origin and post-eruptive contamination assess similarity hypomineralized human enamel. Here, objective address urgent need for an animal model uncover etiology MH improve treatment. Porcine soft at eruption; yet, it hardens quickly form hard surface then resembles with demarcated opacities....

10.3390/ijms242115577 article EN International Journal of Molecular Sciences 2023-10-25

To determine the effect of size and insertion depth irrigation needle on amount apical extruded debris penetration sealer using a confocal laser scanning microscope (CLSM).Twenty maxillary premolars were assigned to 2 groups (n = 10), according tip, 28 G or 30 G. Buccal roots samples irrigated with respective type inserted 1 mm short working length (WL), while palatal 3 WL. Prepared teeth removed from pre-weighed Eppendorf tubes. Canals filled F3 gutta-percha cone rhodamine B dye-labeled AH...

10.5395/rde.2018.43.e2 article EN cc-by-nc Restorative Dentistry & Endodontics 2018-01-01

The teeth of humans and pigs are similar in size, shape, enamel thickness. While the formation human primary incisor crowns takes about 8 months, domestic form their within a much shorter time. Piglets born after 115 days gestation with some erupted that must weaning meet mechanical demands omnivorous diet without failure. We asked whether this short mineralization time before tooth eruption is combined post-eruptive process, how fast process occurs, hardens eruption. To address question, we...

10.3389/fphys.2023.1099645 article EN cc-by Frontiers in Physiology 2023-02-16

To measure the number of days enamel formation between periodic striae Retzius growth lines, periodicity (RP), and to compare this multi-day, or multidien rhythm, body height weight among people from Beijing, China Lhasa, Tibet/China.Subjects requiring dental extractions clinics in (N = 338) Tibet/China 227) provided a tooth size information. Multiple observers examined histological sections teeth recorded RP. RP values were statistically compared weight.In Beijing Lhasa samples,...

10.1080/03014460.2020.1785010 article EN Annals of Human Biology 2020-07-13

ABSTRACT Tooth enamel maturation requires the removal of proteins from mineralizing matrix to allow for crystallite growth until full hardness is reached meet mechanical needs mastication. While this process takes up several years in humans before tooth erupts, it greatly accelerated faster developing pig. As a result, pig teeth erupt with softer, protein-rich that similar hypomineralized human but continues harden quickly after eruption.Proteins, such as albumin, bind crystals and prevent...

10.1101/2024.05.23.595034 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-05-28

Tooth enamel maturation requires the removal of proteins from mineralizing matrix to allow for crystallite growth until full hardness is reached meet mechanical needs mastication. While this process takes up several years in humans before tooth erupts, it greatly accelerated faster-developing pigs. Pig teeth erupt with softer, protein-rich that similar hypomineralized human but continues harden quickly after eruption. Proteins bind crystals and prevent crystal hardening (e.g., albumin) have...

10.1177/00220345241299382 article EN Journal of Dental Research 2024-12-26
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