A5076741150- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Ion Channels and Receptors
- RNA modifications and cancer
- Ion channel regulation and function
- Plant Stress Responses and Tolerance
- Calcium signaling and nucleotide metabolism
- Wnt/β-catenin signaling in development and cancer
- Sirtuins and Resveratrol in Medicine
- Polysaccharides and Plant Cell Walls
- Endoplasmic Reticulum Stress and Disease
University of Pittsburgh
2021-2024
UPMC Hillman Cancer Center
2024
Pennsylvania State University
2021
Mitochondrial Ca2+ uptake tailors the strength of stimulation plasma membrane phospholipase C–coupled receptors to that cellular bioenergetics. However, how by mitochondrial uniporter (MCU) shapes receptor-evoked interorganellar signaling is unknown. Here, we used CRISPR/Cas9 gene knockout, subcellular imaging, and mathematical modeling show MCU a universal regulator intracellular across mammalian cell types. activity sustains cytosolic preventing Ca2+-dependent inactivation store-operated...
T-cell receptor stimulation triggers cytosolic Ca
The endoplasmic reticulum (ER) stores large amounts of calcium (Ca
Aberrant mitochondrial fission/fusion dynamics have been reported in cancer cells. While post translational modifications are known regulators of the machinery, we show that alternative splice variants fission protein Drp1 (