A5072404804- RNA modifications and cancer
- Nuclear Structure and Function
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- ATP Synthase and ATPases Research
- Macrophage Migration Inhibitory Factor
- Circular RNAs in diseases
- GDF15 and Related Biomarkers
University of Pittsburgh
2024
UPMC Hillman Cancer Center
2023-2024
Abstract Objective We previously reported that high expression of the extracellular glutathione peroxidase GPX3 is associated with poor patient outcome in ovarian serous adenocarcinomas, and protects cancer cells from oxidative stress culture. Here we tested if necessary for tumor establishment vivo to identify novel downstream mediators GPX3’s pro-tumorigenic function. Methods was knocked-down ID8 by shRNA test role using a syngeneic IP xenograft model. RNA sequencing analysis carried out...
Aberrant mitochondrial fission/fusion dynamics have been reported in cancer cells. While post translational modifications are known regulators of the machinery, we show that alternative splice variants fission protein Drp1 (
Myelin protein zero-like 3 (MPZL3) is an Immunoglobulin-containing transmembrane with predicted cell adhesion molecule function. Loss of 11q23, where the