A5062736439- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Eosinophilic Disorders and Syndromes
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Blood Coagulation and Thrombosis Mechanisms
- S100 Proteins and Annexins
- Toxin Mechanisms and Immunotoxins
- Oral microbiology and periodontitis research
- Urticaria and Related Conditions
- Extracellular vesicles in disease
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Protease and Inhibitor Mechanisms
- Cardiovascular Issues in Pregnancy
- Parasites and Host Interactions
- Autoimmune and Inflammatory Disorders Research
- Chemical synthesis and pharmacological studies
Hospital General de México
1999-2025
Universidad Nacional Autónoma de México
2010-2025
Leishmania mexicana (Lm) causes localized (LCL) and diffuse (DCL) cutaneous leishmaniasis. DCL patients have a poor cellular immune response leading to chronicity. It has been proposed that CD8 T lymphocytes (CD8) play crucial role in infection clearance, although the of cytotoxicity disease control not elucidated. Lesions shown harbor low numbers CD8, as compared with LCL, leishmanicidal treatment restores numbers. The marked towards parasites led us analyze possible functional differences...
Pentavalent antimonials are the first-line treatment for localized cutaneous leishmaniasis. However, they have disadvantages such as their elevated toxicity, high costs, and parenteral application. Plant-derived compounds may be an alternative against this disease. Previous in vitro studies shown that (3S)-16,17-didehydrofalcarinol (1), a polyacetylene oxylipin isolated from Tridax procumbens, is active Leishmania mexicana. We analyzed mechanism of action compound 1, evaluating reactive...
NKT cells have been associated with protection against Leishmania donovani, yet their role in infections mexicana has not addressed, nor the activation pathway defined after stimulation lipophosphoglycan (LPG). We analyzed of and cytokine production response to LPG. Additionally we compared NKT-cell numbers profile lymph nodes skin lesions induced by BALB/c C57BL/6 mice. show that LPG activates primarily through indirect pathway, initiating TLR2 dendritic (DC), thereby enhancing TLR2, MHC...
Eosinophils are mainly associated with parasitic infections and allergic manifestations. They produce many biologically active substances that contribute to the destruction of pathogens through degranulation microbicidal components inflammatory tissue effects. In leishmaniasis, eosinophils have been found within infiltrate protective immunity against parasite. We analyzed responses from patients localized (LCL) diffuse (DCL) cutaneous as well healthy subjects, when exposed Leishmania...
Exosomes are extracellular microvesicles of endosomal origin (multivesicular bodies, MVBs) constitutively released by eukaryotic cells fusion MVBs to the plasma membrane. The exosomes from Leishmania parasites contain an array parasite molecules such as virulence factors and survival messengers, capable modulating host immune response thereby favoring infection host. We here show that L. mexicana amastigotes (aExo) proteins gp63 PP2C. incubation aExo with bone marrow-derived macrophages...
Leishmania are protozoan parasites that infect macrophages and their survival is partially achieved through inhibition of the cellular oxidative burst by parasite lipophosphoglycan (LPG). PKCα predominant PKC isoenzyme required for macrophage burst, yet it not known if different susceptibility BALB/c C57BL/6 mice to mexicana could be related PKCα. We analysed effect L. promastigotes LPG on expression its activity in both mouse strains. Our data show was altered either or promastigotes. Yet...
Background Periodontal disease is considered one of the most prevalent chronic infectious diseases, often leading to disruption tooth-supporting tissues, including alveolar bone, causing tooth mobility and loss. Porphyromonas gingivalis major etiological agent this disease, having a plethora virulence factors, including, lipopolysaccharides (LPS), hemolysins, proteinases. Antimicrobial peptides are main components innate immune response that inhibit growth P. . The aim study was analyze...
Trypanosoma cruzi infection leads to Chagas disease (CD), a neglected tropical of significant public health importance in South and Central America other, non-endemic, countries. Pregnant women their children are particular screen as T. can be transmitted vertically. The objective this study was for among pregnant from endemic areas seen at the Hospital General de Mexico prenatal care, so that they may quickly connected CD treatment. were recruited through hospital clinic screened using...
We report the case of a patient with cutaneous leishmaniasis who showed rapidly progressing ulcerative lesion after traveling to multiple countries where different Leishmania species are endemic. Diagnosis tropica, an exotic in Mexico was established by using serological and molecular tools.
Parasites have been engineered to express fluorescent reporter proteins, yet the impact of red proteins on Leishmania infections remains largely unknown. We analysed infection outcome mexicana parasites for constitutive expression mKate protein and evaluated their immunogenicity in BALB/c mice. Infection mice with transfected L. (LmexmKate ) caused enlarged lesion sizes, leading ulceration, containing more parasites, as compared LmexWT . The showed immunogenic properties inducing antibody...