A5010321609- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Antimicrobial Peptides and Activities
- Microbial Metabolism and Applications
- Biochemical and Structural Characterization
- Listeria monocytogenes in Food Safety
- Marine Sponges and Natural Products
- Plant Pathogenic Bacteria Studies
- International Law and Aviation
- Antibiotic Resistance in Bacteria
- Plant-Microbe Interactions and Immunity
- Bacterial biofilms and quorum sensing
- Salmonella and Campylobacter epidemiology
- Genomics and Phylogenetic Studies
- Legal Cases and Commentary
- Legal Systems and Judicial Processes
- Marine Toxins and Detection Methods
- Antimicrobial Resistance in Staphylococcus
- Food Safety and Hygiene
University of Lincoln
2017-2020
Institute of Biological, Environmental and Rural Sciences
2017
Aberystwyth University
2017
Loyola University Chicago
2003
The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its class that has shown vivo antibacterial efficacy. In this work, we designed synthesized 10 new ready analogues. These analogues showed highly potent activities against aureus, MRSA, vancomycin-resistant enterococci (VRE) vitro. One analogue,...
The myxobacterium Myxococcus xanthus is a predatory member of the soil microfauna, able to consume bacteria (Gram-negative, Gram-positive), archaea, and fungi. Many potential prey M. communicate amongst themselves using acyl homoserine lactones (AHLs) as quorum signals. cannot itself produce AHLs, but could potentially benefit by responding exogenous AHLs produced during signaling between proximal prey. Four different side chain length were tested all found delay sporulation vegetative...
Leu<sub>10</sub>-teixobactin and Ile<sub>10</sub>-teixobactin have shown comparable activity to natural teixobactin.
We have synthesised <bold>8</bold> simplified, potent teixobactin analogues by replacing <sc>l</sc>-<italic>allo</italic>-enduracididine with its isosteres.
Bacterial pathogens are rapidly evolving resistance to all clinically available antibiotics. One part of the solution this complex issue is better understand mechanisms new and existing Here, we focus on two Teixobactin a recently discovered promising antibiotic that claimed "kill without detectable resistance" (L. L. Ling, T. Schneider, A. J. Peoples, Spoering, et al., Nature 517:455-459, 2015, https://doi.org/10.1038/nature14098). Moenomycin A has been extensively used in animal husbandry...
Teixobactin is a highly potent cyclic depsipeptide which kills broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance. In this work, we describe the design and rapid synthesis novel teixobactin analogues containing two cysteine moieties, corresponding disulfide-bridged analogues. These differ from previously reported analogues, an Arg10-teixobactin, in terms their macrocyclic ring size, feature...