Н. И. Смирнова

ORCID: 0000-0003-4785-4110
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About
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Research Areas
  • Vibrio bacteria research studies
  • Aquaculture disease management and microbiota
  • Yersinia bacterium, plague, ectoparasites research
  • Bacteriophages and microbial interactions
  • Salmonella and Campylobacter epidemiology
  • Escherichia coli research studies
  • Microbial Community Ecology and Physiology
  • Identification and Quantification in Food
  • Polysaccharides and Plant Cell Walls
  • Bacillus and Francisella bacterial research
  • Genomics and Phylogenetic Studies
  • Polysaccharides Composition and Applications
  • Enzyme Production and Characterization
  • Child Nutrition and Water Access
  • Microbial Metabolic Engineering and Bioproduction
  • Cassava research and cyanide
  • Carbohydrate Chemistry and Synthesis
  • Synthesis and Reactions of Organic Compounds
  • Metabolomics and Mass Spectrometry Studies
  • Bacterial Genetics and Biotechnology
  • Glycosylation and Glycoproteins Research
  • Liquid Crystal Research Advancements
  • Legionella and Acanthamoeba research
  • Genetics, Bioinformatics, and Biomedical Research
  • Organic Chemistry Synthesis Methods

Russian Scientific Research Institute Microbe
2011-2022

Rostov-on-Don Anti-plague Institute Rospotrebnadzor
2019

A N Bach Institute of Biochemistry
2000-2017

Federal Center Research Fundamentals of Biotechnology
2017

Russian Academy of Sciences
2017

Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2014-2016

Irkutsk Antiplague Research Institute of Siberia and Far East
2003-2008

Saratov Research Institute of Traumatology and Orthopedics
2001

Scientific Research Institute of Organic Intermediates and Dyes
1976-1991

Abstract The paper reports synthesis of LC derivatives different chemical classes containing terminal groups ‒OCHF2, ‒OCF3, ‒SCHF2, ‒OCnF2n +1 and ‒CnF2n + 1 indicates their phase transition points physico-chemical properties.

10.1080/00268949108036197 article EN Molecular crystals and liquid crystals 1991-12-01

Abstract The liquid crystalline 6-alkoxynicotinic acids were prepared, and their transition temperatures measured. isomeric 5-alkoxypicolinic are not mesomorphic. A series of 2, 6- 2,5-disubstituted benzazoles also synthesized. effects a molecule geometry, central linkages heteroatom on the mesomorphic properties these compounds discussed.

10.1080/15421407608084344 article EN Molecular crystals and liquid crystals 1976-01-01

The cell envelope of Helicobacter pylori contains a lipopolysaccharide (LPS) essential for the physical integrity and functioning bacterial membrane. O-chain this LPS frequently expresses type 2 Lewis x (Lex) y (Ley) blood group antigens that mimic human gastric mucosal cell-surface glycoconjugates. This article describes isolation structural analysis from clinical isolate H. strain PJ2 lacks Le but is still capable colonization. Subsequent composition, methylation, CE-ESMS analyses revealed...

10.1093/glycob/cwg106 article EN Glycobiology 2003-08-07

Main problems of system epidemiologic control for cholera active in Russian Federation, as well laboratory diagnostics and vaccine prophylaxis this especially dangerous infection, that had emerged the contemporary period ongoing 7th pandemic ofcholera, are discussed. Features genome natural strains Vibrio cholerae El Tor biovar, possess a potential epidemic threat, problems, have during isolation these from samples water surface bodies their monitoring, also examined. The main direction...

10.36233/0372-9311-2016-1-89-101 article EN cc-by Journal of microbiology epidemiology immunobiology 2016-02-28

To carry out comparative molecular genetic analysis of highly pathogenic atypical Vibrio cholerae strains biovar El Tor, isolated in the territory RF, order to determine micro-evolutionary alterations cholera agent modern period.38 clinical have been examined by means polymerase chain reaction, sequencing and MLVA-analysis. The selected were at different periods time during epidemic complications differed between each other virulence.It is demonstrated that new variants emerged course...

10.15690/vramn.v69i7-8.1109 article EN Annals of the Russian academy of medical sciences 2014-01-01

Abstract Under study were the UV and PMR spectra as well electron structure of 4-alkyl, 4-alkoxy-4'-cyanobiphenyls, 6-p-alkylphenyI-, 6-p-alkoxyphenyl-3-cyanopyridines 5-alkyl-2-p-cyanophenylpyridines in ground first excited states. To these compounds a quantitative method is offered for determination rotation angle between planes bicyclic molecular fragments based on excitation theory within frames Hückel technique spectroscopy data.

10.1080/00268948108076135 article EN Molecular crystals and liquid crystals 1981-02-01

ABSTRACT Here, we present the draft whole-genome sequence of Vibrio cholerae O1 El Tor strains 76 and M3265/80, isolated in Mariupol, Ukraine, Moscow, Russia. The presence various mutations detected virulence-associated mobile elements indicates high genetic similarity reported here with new highly virulent variants cholera agent V. .

10.1128/genomea.01640-16 article EN Genome Announcements 2017-02-23

Determined is cholera toxin production by altered Vibrio cholerae O1 eltor strains, isolated on the territory of Russia in 1993-2010, which contain classical type ctxB gene. Studied are their genetic characteristics related to this virulence factor. that variants yield 10 20 times more than typical strains. Changes promotor region ctxAB operon not detected but elucidated 90 % studied strains two copies CTXϕ prophage genome whereas carry one copy prophage. Despite higher number prophage,...

10.21055/0370-1069-2012-1(111)-57-61 article EN cc-by Problems of Particularly Dangerous Infections 2012-02-20

Displayed is the possibility of differentiation between typical and genetically altered strains Vibrio cholerae biovar El Tor, which vary in their virulence epidemic potential, by means MLVA. Determined a significant genetic diversity gene-variants, probably, due to polyclonal origin continuous alterations within genome under influence varying environmental factors.

10.21055/0370-1069-2012-4-39-43 article EN cc-by Problems of Particularly Dangerous Infections 2012-08-20
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