A5069228802- RNA modifications and cancer
- Neurogenetic and Muscular Disorders Research
- Sleep and related disorders
- Bladder and Urothelial Cancer Treatments
- Sleep and Wakefulness Research
- RNA Research and Splicing
- Epilepsy research and treatment
- Urinary and Genital Oncology Studies
- Viral gastroenteritis research and epidemiology
- Pharmaceutical Economics and Policy
- Organ Transplantation Techniques and Outcomes
- Pressure Ulcer Prevention and Management
- Flow Measurement and Analysis
- Opioid Use Disorder Treatment
- Lysosomal Storage Disorders Research
- Salmonella and Campylobacter epidemiology
- Primary Care and Health Outcomes
- Burn Injury Management and Outcomes
- Pharmaceutical industry and healthcare
- Infant Nutrition and Health
- Acupuncture Treatment Research Studies
- Urological Disorders and Treatments
- Bacteriophages and microbial interactions
- Zebrafish Biomedical Research Applications
- Glycosylation and Glycoproteins Research
University of East Anglia
2018-2021
Norwich Research Park
2018
University of Edinburgh
2016-2018
Mott MacDonald (United Kingdom)
2016-2018
University of Sheffield
2015
Institute of Molecular and Cell Biology
2015
St Helier Hospital
2003
Conquest Hospital
2003
North Tyneside General Hospital
1994-1995
Public Health Laboratory
1994
Tumour cell implantation may be a factor in the aetiology of recurrent well-differentiated superficial bladder tumours. A prospective trial is reported which single dose intravesical thiotepa was administered to group randomly selected patients immediately after cystodiathermy. control treated by cystodiathermy alone and tumour recurrence 2 groups compared. Significantly fewer thiotepa-treated developed there also significantly reduced incidence pure vault this group. The beneficial effects...
Degeneration and loss of lower motor neurons is the major pathological hallmark spinal muscular atrophy (SMA), resulting from low levels ubiquitously-expressed survival neuron (SMN) protein. One remarkable, yet unresolved, feature SMA that not all are equally affected, with some populations displaying a robust resistance to disease. Here, we demonstrate selective vulnerability distinct pools arises fundamental modifications their basal molecular profiles. Comparative gene expression...
The autosomal recessive neuromuscular disease spinal muscular atrophy (SMA) is caused by loss of survival motor neuron (SMN) protein. Molecular pathways that are disrupted downstream SMN therefore represent potentially attractive therapeutic targets for SMA. Here, we demonstrate targeting ubiquitin as a consequence depletion, increasing levels one key ubiquitination enzyme (ubiquitin-like modifier activating 1 [UBA1]), represents viable approach treating Loss UBA1 was conserved response...
Abstract Background Sleep disturbance is common in dementia and often treated with Z-drugs (zopiclone, zaleplon, zolpidem). While some observational studies suggest that are associated adverse events such as falls fracture risks older people, this has not been studied dementia. Methods We used data from 27,090 patients diagnosed between January 2000 March 2016 the Clinical Practice Research Datalink linked to Hospital Episodes Statistics England. compared for 3532 newly prescribed by...
Deafferentation of motor neurons as a result defective sensory-motor connectivity is critical early event in the pathogenesis spinal muscular atrophy, but underlying molecular pathways remain unknown. We show that restoration ubiquitin-like modifier-activating enzyme 1 (UBA1) was sufficient to correct cord mice with atrophy. Aminoacyl-tRNA synthetases, including GARS, were identified downstream targets UBA1. Regulation GARS by UBA1 occurred via non-canonical pathway independent...
older people with frailty are particularly high users of healthcare services, however a lack standardised recording in different electronic datasets has limited investigations into service usage and demand the frail population.to investigate community patients using index (eFI) as measure frailty.a retrospective cohort study anonymised linked patient data from primary care, services acute hospitals Norfolk.patients aged 65 over who had an eFI assessment score established their care record...
ABSTRACT DISRUPTED-IN-SCHIZOPHRENIA (DISC1) has been one of the most intensively studied genetic risk factors for mental illness since it was discovered through positional mapping a translocation breakpoint in large Scottish family where balanced chromosomal found to segregate with schizophrenia and affective disorders. While evidence being central disease pathogenesis original is compelling, recent genome-wide association studies have not common variants at DISC1 locus associated wider...
Consumption of milk contaminated with Campylobacter jejuni has been described as a cause human enteritis. Although faecal contamination the organism frequently described, direct excretion into rarely linked cases infection. We describe investigations undertaken following isolation from samples unpasteurized prior to retail. Results epidemiological including typing isolates using pyrolysis mass spectrometry, Penner and Lior serotyping, biotyping, phage restriction fragment length polymorphism...
The survival rates in 200 patients with terminal renal failure treated by maintenance haemodialysis and transplantation were analysed. overall rate (+/- SE) was 81-4 +/- 3% at two years, 68-4 4% five 60-8 4-8% eight years. Survival inversely related to age: those aged 15-34 years 89-7 3-7% 87-8 4-1% 83-9 5-5% Eighty per cent of the surviving able work full time. returned dialysis after graft rejection 87-5% 8-3 three
Background Sleep disturbance affects around 60% of people living with dementia and can negatively affect their quality life that carers. Hypnotic Z-drugs (zolpidem, zopiclone zaleplon) are commonly used to treat insomnia, but safety efficacy have not been evaluated for dementia. Objectives To estimate the benefits harms in sleep disturbance. Design A series observational cohort studies using existing data from (1) primary care linked hospital admission (2) clinical Data sources Primary study...
To demonstrate the stability of microorganisms preserved in LENTICULE discs, employed by EQUAL Scheme for Indicator Organisms.Five sample batches containing several indicator organism parameters were each despatched two separate distributions at intervals up to 24 months apart. A comparison participants' median counts and bar charts their cumulated results was then made.The demonstrated that discs provided a remarkably stable preparation format maintenance viable organisms reproducible...
Sleep disturbance affects around 60% of people living with dementia (PLwD), significant impact on the PLwD‘s and informal carer's quality life. Hypnotic Z-drugs (zolpidem, zopiclone zaleplon) are commonly used to treat insomnia in elderly but can cause adverse events including falls, fractures, daytime cognitive impairment, which might be particularly harmful for PLwD. However, safety efficacy this vulnerable group have not been fully evaluated. We aimed examine unintended effects Z-drug use...
Background and Purpose: Extracorporeal shockwave lithotripsy (SWL) is an effective noninvasive, outpatient method of stone clearance. In our unit, it performed using a combination oral analgesia intravenous sedation, which allows us to treat therapeutic levels in the vast majority patients. However, we have encountered patients who do not tolerate various elements protocol thus cannot be treated full effect. The options for these people are currently limited either SWL under formal sedation...
Approximately 60% of people with dementia (PwD) experience sleep disturbance including insomnia and excessive daytime sleeping. Hypnotic Z-drugs (zolpidem, zopiclone zaleplon) are used to treat in the elderly but can cause adverse events e.g. falls cognitive impairment which might be particularly harmful for PwD. However, safety efficacy this group have not been fully evaluated. Given importance offering respite from PwD carers, type events, it is essential we understand benefits harms these...
The era of patient-focused care has brought a new dimension to medical treatment. Now, as well looking for therapies that work effectively, they must also be acceptable patients. Previous studies in this department have shown stone clearance rates with lithotripsy compare favourably national standards, but very little been done regarding patient's own perception the experience.A postal survey was conducted all patients attending unit over period 1 year, questioning their opinion aspects...
Journal Article Duplicate split samples for internal quality control in routine water microbiology Get access N.F Lightfoot, Lightfoot Public Health Laboratory, Institute of Pathology, Newcastle General Hospital, upon Tyne Search other works by this author on: Oxford Academic Google Scholar H.E. Tillett, Tillett PHLS Communicable Diseases Surveillance Centre (CDSC), London, UK P. Boyd, Boyd S. Eaton Letters Applied Microbiology, Volume 19, Issue 5, 1 November 1994, Pages 321–324,...
not given, and there was no indication that these figures were comparable for each of the six treatments administered, which included iso- prenaline plus phcnylephrine.In Dr. Hum-'s let- ter this information available, but it indica- ted (a) mean PaO., before isoprenaline phenylephrine (66 mm.Hg) consider- ably lower than salbutamol (74 mm.Hg), (b) change in PaO,, after drug administration only + 1-7 mm.Hg case phenylephrine, -3-7 salbutamol.The difference favour