A5088771452- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Soybean genetics and cultivation
- Pancreatitis Pathology and Treatment
- Legume Nitrogen Fixing Symbiosis
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant pathogens and resistance mechanisms
- Agronomic Practices and Intercropping Systems
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
- Nematode management and characterization studies
- Virus-based gene therapy research
- Lipoproteins and Cardiovascular Health
- Neurotransmitter Receptor Influence on Behavior
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects and Assays
- Gastric Cancer Management and Outcomes
- Poxvirus research and outbreaks
- IgG4-Related and Inflammatory Diseases
- Atherosclerosis and Cardiovascular Diseases
- Phytoestrogen effects and research
- Marine and Coastal Research
National Agriculture and Food Research Organization
2014-2025
Institute of Crop Science
2022-2025
Sapporo City General Hospital
2021-2024
Hokkaido University
2017-2023
Keio University
2014-2023
Hokkaido University Hospital
2018-2023
Tohoku Agricultural Research Center
2011-2022
Kanagawa Cancer Center
2020
Kanagawa Prefectural Hospital Organization
2020
Okinawa Prefectural Chubu Hospital
2013-2018
Triterpene saponins are a diverse group of biologically functional products in plants. Saponins usually glycosylated, which gives rise to wide diversity structures and functions. In the A soybean (Glycine max), differences terminal sugar species located on C-22 chain an aglycone core, soyasapogenol A, were observed be under genetic control. Further analyses mapping revealed that structural glycosylation was determined by multiple alleles single locus, Sg-1, led identification...
The use of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has been rapidly expanding as a useful examination technique which enables highly accurate histological diagnosis. Reports tumor dissemination induced by EUS-FNA are rare [1] [2] [3] [4] [5]. We recently encountered case in cells were observed the puncture line surgically resected specimen after EUS-FNA, and posterior wall upper gastric body was later observed.
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) provides high diagnostic accuracy with a low incidence of procedural complications. However, it occasionally causes serious complications, and factors that increase the susceptibility to such adverse events remain unknown.We aimed examine post-procedural determine risk associated EUS-FNA pancreatic solid lesions.This single-center retrospective study included 316 consecutive patients lesions who underwent 327 procedures from April...
Abstract The objective of this study was to identify quantitative trait loci (QTL) affecting fitness hybrids between wild soybean ( Glycine soja ) and cultivated max ). Seed dormancy seed number, both which are important for fitness, were evaluated by testing artificial G. × in a multiple‐site field trial. Generally, the F 1 hybrid derivatives from self‐pollination lower than that due loss dormancy, whereas with higher proportions genetic background comparable . These differences genetically...
Objectives Anti-centromere antibodies (ACAs) are detected in patients with various autoimmune diseases such as Sjögren’s syndrome (SS), systemic sclerosis (SSc) and primary biliary cholangitis (PBC). However, the targeted antigens of ACAs not fully elucidated despite accumulating understanding molecular structure centromere. The aim this study was to comprehensively reveal autoantigenicity centromere proteins. Methods A antigen library including 16 principal subcomplexes composed 41 proteins...
Among commonly applied molecular markers, simple sequence repeats (SSRs, or microsatellites) possess advantages such as a high level of polymorphism and codominant pattern inheritance at individual loci. To facilitate systematic rapid genetic mapping in soybean, we designed genotyping panel comprised 304 SSR markers selected for allelic diversity chromosomal location so to provide wide coverage. Most primer pairs the were redesigned yield amplicons 80–600 bp multiplex polymerase chain...
<b>Background and study aims:</b> There are two types of endoscopic ultrasound (EUS) endoscope, the radial scanning (RS) curved linear array (CL). The type EUS endoscope used at a first intent depends on local expertise, habits sometimes how examination is reimbursed. In Japan, RS mainly for observation, whereas CL primarily histopathological diagnosis treatment. We compared imaging capabilities in evaluating pancreaticobiliary region, which has not been performed previously. Patients...
A 52-year-old man was referred for further investigation of a gastric submucosal tumor on the greater curvature antrum.Endoscopic ultrasonography demonstrated hypoechoic solid mass, which primarily connected to muscular layer stomach.We performed endoscopic ultrasoundguided fine-needle aspiration biopsy.The pathological examination showed proliferation oval-shaped cells with nest formation, stained strongly positive muscle actin, and negative c-kit, CD34, CD56, desmin, S-100, chromogranin,...
A new soybean cultivar, 'Soramizuki,' was developed by crossing 'Fukuyutaka A1 gou' with 'UA4805' to integrate the high-yield characteristics of a US cultivar into Japanese cultivar. While high yield and stability 'Soramizuki' have been confirmed, specific high-yielding factors were previously unknown. This study compared components 'UA4805,' 'Sachiyutaka in experimental fields during 2021 2023. In these two-year experiments, demonstrated significantly higher than gou.' Despite significant...
SUMMARY In soybean breeding, using the recessive male‐sterile ms5 gene, derived from fast neutron mutagenesis, for recurrent selection is advantageous because of d2 locus, which controls cotyledon color in mature seeds and can be used as a phenotypic marker male sterility. However, occasional self‐fertilization occurs elimination linkage instability Elucidating mechanism gene responsible sterility may resolve these problems. Using fine mapping with 15 simple sequence repeat (SSR) markers, we...
Background and Aim . EUS-guided transmural drainage (EUS-GTD) is now considered a minimally invasive effective alternative to surgery for of symptomatic pancreatic pseudocysts. However, the technique rather difficult, sometimes serious complications occur patients undergoing this procedure. We retrospectively evaluated efficacy, safety, long-term follow-up results EUS-GTD pseudocyst. Methods Sixty-seven with pseudocyst who underwent from April 2000 March 2011 were enrolled. (1) technical...
Although an indeterminate growth habit is attractive to develop high-yield soybean varieties with higher number of pods (Glycine max (L). Merr.), lodging in remains a problem Japan. As the semi-determinate have shorter main stem length than varieties, this trait can be useful improve high yield and low risk. We introduced genes Dt1 Dt2, which regulate habit, into three determinate by backcrossing evaluated resulting effects on tendency under four different growing environments. The degree...
OBJECTIVES: Biliary tract cancer (BTC) is an aggressive malignant tumor, and biomarker-based clinical trials for this are currently ongoing. Endoscopic ultrasound–guided fine needle aspiration (EUS-FNA) a safe procedure enables pathological diagnoses; however, it uncertain whether tiny tumor sample of BTC obtained through EUS-FNA can be analyzed diverse genetic alterations in the development tolerance BTC. Thus, we aimed to verify feasibility analyses with samples METHODS: Targeted amplicon...
Our previous study revealed the efficacy and safety of large balloon dilation (LBD) technique. However, there is insufficient objective data about recurrence rate. The aim this was to compare rate common bile duct (CBD) stones between patients treated with without LBD.Patients recurrent CBD April 2006 August 2010, who had a history endoscopic sphincterotomy (ES), were enrolled. Patients excluded if they diameter less than 10 mm or their largest stone <10 mm.A total 62 consecutive...
An epidermoid cyst arising within an intrapancreatic accessory spleen (ECIAS) is rare, and also difficult to correctly diagnose before surgery. It mostly misdiagnosed as a cystic tumor, such mucinous neoplasm or solid tumor with degeneration, neuro endocrine tumor. We herein report case of ECIAS perform literature review 35 reports ECIAS. Although the preoperative diagnosis using conventional imaging relatively make, careful examinations features on computed tomography magnetic resonance...
Saponins are a diverse group of secondary metabolites widely distributed in plants. Some saponins soybean seeds have medicinal properties, but the terminal acetylated sugar at C-22 position A seed hypocotyls causes bitter and astringent taste. We used cultivated wild accessions classified into four different saponin phenotypes, including non-acetylated A0-αg deacetyl-Af, as parents to obtain F2 populations population recombinant inbred lines test their genetic relationship. The gene...
The present study was conducted to evaluate the benefits of indeterminate growth habit in breeding improve yield potential Japanese soybean varieties, which exclusively have determinate habit. Two populations recombinant inbred lines (RILs) derived from crosses between cultivars and US were grown Akita Kyoto, seed weight per plant (SW) its components compared RILs. difference SW two habits RILs varied depending on maturation time. early significantly higher than that ones Akita, but not...
Tyrosine kinase inhibitors (TKIs) were first approved for treating radioactive iodine‑refractory differentiated thyroid cancer (DTC) and anaplastic (ATC) 5 years ago. Among them, lenvatinib has a high response rate become the first‑line drug cancer. Although it rate, is also characterized by frequency of adverse events (AEs). AEs previously reported in phase II study occurred after practical application TKI therapy. However, type that significantly different. The present investigated...
Objectives Recent evidences have revealed that anti-SSA/SSB antibodies, the major autoantibodies in Sjögren's syndrome (SS), are produced salivary glands. This study aims to clarify overall of autoantibody production at lesion site, including anti-centromere antibody (ACA)-positive SS. Methods Antibodies antibody-secreting cells human glands were as recombinant antibodies. The reactivity these antibodies and their revertants investigated by ELISA newly developed antigen-binding beads assay,...