A5082969854- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Amyotrophic Lateral Sclerosis Research
- Optical Coherence Tomography Applications
- Intraocular Surgery and Lenses
- Ocular and Laser Science Research
- Ocular Infections and Treatments
- Drug-Induced Ocular Toxicity
- Ocular Oncology and Treatments
- Glioma Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- melanin and skin pigmentation
- Prion Diseases and Protein Misfolding
- Ocular Disorders and Treatments
- Alzheimer's disease research and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Biochemical Acid Research Studies
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Parkinson's Disease Mechanisms and Treatments
University of Utah
2020-2022
Oregon Health & Science University
2017-2020
Northwestern University
2014-2017
Fondazione G.B. Bietti
2016-2017
Kresge Eye Institute
2016
Detroit Medical Center
2016
Pisgah Astronomical Research Institute
2012-2014
University of Wisconsin–Madison
2013
Diabetic retinopathy (DR) can lead to significant vision loss and blindness has a particularly high prevalence in patients with type 1 diabetes (DM1). In this study, we investigate quantitative differences optical coherence tomography angiography (OCTA) data between DM1 no or mild signs of non-diabetic subjects.Optical imaging was performed on nonproliferative diabetic healthy, age-matched controls. Parafoveal vessel density foveal avascular zone (FAZ) area the deep capillary plexus (DCP)...
Best disease (BD) is an inherited degenerative of the human macula that results in progressive and irreversible central vision loss. It caused by mutations retinal pigment epithelium (RPE) gene BESTROPHIN1 (BEST1), which, through mechanism(s) remain unclear, lead to accumulation subretinal fluid autofluorescent waste products from shed photoreceptor outer segments (POSs). We employed iPS cell (hiPSC) technology generate RPE BD patients unaffected siblings order examine cellular molecular...
To describe an automated algorithm to quantify the foveal avascular zone (FAZ), using optical coherence tomography angiography (OCTA), and compare its performance for diagnosis of diabetic retinopathy (DR) association with best-corrected visual acuity (BCVA) that extrafoveal area (EAA).We obtained 3 × 3-mm macular OCTA scans in patients various levels DR healthy controls. An based on a generalized gradient vector flow (GGVF) snake model detected FAZ, metrics assessing FAZ size irregularity...
Purpose: To characterize the density and distribution of radial peripapillary capillary plexus (RPCP) its relationship with retinal nerve fiber layer (NFL) thickness in healthy subjects. Methods: Using spectral-domain optical coherence tomography (OCT), split-spectrum amplitude decorrelation angiography algorithm automated montaging, wide-field OCT (OCTA) was used to measure RPCP (CD) NFL thickness. Polar sector-average CD maps were also created on each eye. Results: Wide-field OCTA (8 × 8...
Retinal structural changes in subjects with mild cognitive impairment (MCI) remain a subject of controversy.We investigated the correlation between optical coherence tomography (OCT) retinal sublayers, including nerve fiber layer (RNFL), and function amnestic MCI compared OCT findings matched controls. We also performed meta-analysis world literature using random-effects model.We found no statistically significant differences (aMCI) In aMCI subjects, we an inverse relationship RNFL thickness...
Microphthalmia-associated transcription factor (MITF) is a master regulator of pigmented cell survival and differentiation with direct transcriptional links to cycle, apoptosis pigmentation.In mouse, Mitf expressed early uniformly in optic vesicle (OV) cells as they evaginate from the developing neural tube, null mutations result microphthalmia pigmentation defects.However, homozygous MITF have not been identified humans; therefore, little known about its role human retinogenesis.We used...
Recent studies have linked a vision-threatening maculopathy with long-term use of pentosan polysulfate sodium (PPS).To evaluate the disease course in PPS-associated after drug cessation.In this retrospective case series, patients diagnosed at least 6 months follow-up cessation who were treated Emory Eye Center, Atlanta, Georgia, or Casey Institute, Portland, Oregon, included. Data collected from April 2014 through November 2019.Change visual acuity and retinal imaging characteristics over...
Our objective was to present clinicopathologic evidence of anterior visual pathway involvement in patients with amyotrophic lateral sclerosis (ALS) secondary a C9orf72 mutation. Two related from an extended pedigree ALS and GGGGCC hexanucleotide repeat expansion the gene (C9-ALS) underwent neuro-ophthalmologic examination. Following death tissue donation younger patient, histopathologic examination retina, optic nerve central nervous system (CNS) performed. Ophthalmologic revealed contrast...
Abstract Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder that may have anterior visual pathway involvement. In this study, we compare the macular structure of patients with ALS to healthy controls and examine correlations between sub-layer thickness measurements pulmonary function tests disease duration. underwent optical coherence tomography (OCT) imaging obtain cube scans right eye. Macular OCT data from age-matched subjects were provided by reading center....
Visible light optical coherence tomography (vis-OCT) is an emerging label-free and high-resolution 3-dimensional imaging technique that can provide retinal oximetry, angiography, flowmetry in one modality.In this paper, we studied the organization of arterial venous circulation rats using vis-OCT.Arterioles were found predominantly superficial vascular plexus whereas veins tended to drain capillaries from deep capillary plexus.After that, determined oxygen metabolic rate supported by...
Purpose: The purpose of this study was to analyze the natural history and phenotypic overlap patients with microcephaly a chorioretinopathy or familial exudative vitreoretinopathy (FEVR) ocular phenotype caused by mutations in KIF11, TUBGCP4, TUBGCP6. Methods: Patients diagnosed congenital FEVR were included. Molecular investigations consisted targeted genetic sequencing. Data from medical records, ophthalmologic examination imaging, electroretinography, visual fields analyzed for systemic...
To quantify the external limiting membrane (ELM) disruption and photoreceptor volume changes in eyes with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using Spectral Domain Optical Coherence Tomography (SD-OCT) at resolution phases.Retrospective study of 10 5 patients APMPPE. Intact ELM Bruch's were manually traced ImageJ software their lengths from each scan macular summed. The ratio intact length/Bruch's length was calculated. Also, two-dimensional areas specific...
To quantify photoreceptor volume changes after successful surgical repair of macula-off retinal detachment and to correlate these volumetric postoperative best-corrected visual acuity (BCVA).Retrospective study 15 eyes patients with who underwent repair. A minimum 4 optical coherence tomography scans that straddled the foveal center was used central (central 1 mm).Mean at first visit 0.451 mm, increasing 0.523 mm final (P = 0.004). Mean BCVA improved from 1.13 ± 0.59 logarithm angle...
BACKGROUND AND OBJECTIVE: To report on the microbiology, management, and visual outcomes of intravitreal injection (IVI)-associated, culture-proven endophthalmitis. PATIENTS METHODS: All patients seen at a tertiary referral center with endophthalmitis associated an IVI between June 2007 July 2017 were included in this retrospective analysis. RESULTS: Thirty-five culture-positive following identified. gram-positive organisms (34 35) susceptible to vancomycin. Cases due pathogens oral or...
Abstract Age-related macular degeneration (AMD), a multifactorial, neurodegenerative disease, is leading cause of vision loss. With the rapid advancement DNA sequencing technologies, many AMD-associated genetic polymorphisms have been identified. Currently, most time consuming steps these studies are patient recruitment and phenotyping. In this study, we describe development an automated algorithm to identify neovascular (wet) AMD, non-neovascular (dry) AMD control subjects using electronic...
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Purpose: To determine whether improvements in microperimetry testing are associated with anatomic resolution after ocriplasmin treatment patients symptomatic vitreomacular adhesion (VMA)/vitreomacular traction and relatively preserved baseline best-corrected visual acuity (BCVA). Methods: Patients received a single 125- μ g intravitreal injection were followed longitudinally for 6 months optical coherence tomography, BCVA testing, microperimetry. Visual function changes compared between eyes...
Blood-brain barrier disruption (BBBD) is a systemic therapy for malignant central nervous system (CNS) tumors that has been linked to poorly understood pigmentary maculopathy.To examine the rate of and risk factors development BBBD-associated maculopathy assess whether there can be visually significant progression after completion therapy.In this retrospective case series, data from February 1, 2006, through December 31, 2019, were collected patients treated with osmotic BBBD at single...
BACKGROUND AND OBJECTIVE: To describe the incidence, characteristics, and risk factors of a pigmentary maculopathy in patients with primary central nervous system (CNS) lymphoma treated blood–brain barrier disruption (BBBD) therapy. PATIENTS METHODS: This retrospective chart review included biopsy-proven CNS or without BBBD therapy who underwent an ophthalmic examination after starting systemic treatment. Clinical data all available retinal imaging were analyzed. RESULTS: Fifty-eight met...