A5000720276- Multiple Sclerosis Research Studies
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Facial Nerve Paralysis Treatment and Research
- Glioma Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Ocular Diseases and Behçet’s Syndrome
- Trigeminal Neuralgia and Treatments
- Systemic Lupus Erythematosus Research
- Cerebral Venous Sinus Thrombosis
- Optical Coherence Tomography Applications
- Atherosclerosis and Cardiovascular Diseases
- Ocular and Laser Science Research
- Immunodeficiency and Autoimmune Disorders
- Ocular Oncology and Treatments
- Vasculitis and related conditions
- Telemedicine and Telehealth Implementation
- Retinal and Macular Surgery
- Biochemical Acid Research Studies
- Diversity and Career in Medicine
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Otitis Media and Relapsing Polychondritis
Oregon Health & Science University
2017-2025
VA Portland Health Care System
2017-2025
Pacific University
2023
Veterans Health Administration
2022
Advanced Imaging Research (United States)
2017
University of California, Davis
2011-2013
NYU Langone Health
2013
Johns Hopkins Medicine
2013
Johns Hopkins University
2013
Prevent Blindness
2013
<h3>Objective:</h3> To determine whether lipoic acid (LA), an endogenously produced antioxidant, slowed the whole-brain atrophy rate and was safe in secondary progressive MS (SPMS). <h3>Methods:</h3> Patients with SPMS aged 40–70 years enrolled a single center, 2-year, double-blind, randomized trial of daily oral 1,200 mg LA vs placebo. Primary outcome change annualized percent brain volume (PCBV). Secondary outcomes were changes rates segmented brain, spinal cord, retinal substructures,...
Abstract A characteristic feature of the CNS inflammatory response in multiple sclerosis (MS) is intrathecal synthesis IgG and presence oligoclonal bands. strong correlation between CD138+ plasma blast numbers MS cerebrospinal fluid (CeSF) suggests that these cells are major Ab-secreting cell type CeSF. Sequencing V regions from CeSF has revealed somatically mutated expanded clonotypes consistent with an Ag-targeted response. In present study, single-cell RT-PCR analysis 11 patients...
Patients with multiple sclerosis (MS) demonstrate thinning of peripapillary retinal nerve fiber layer (RNFL) and decreased macular volume as measured by optical coherence tomography (OCT). To our knowledge, there are no previous reports from a large MS OCT database strict quality control measures that quantitate RNFL macula in patients relapsing-remitting sclerosis.The University California Davis Reading Center gathered data at baseline part the North American phase 3 trial fingolimod...
Casey Eye Institute, Oregon Health & Science University, VA Portland Care System, Portland, Oregon.
Background: Limited prospective information exists regarding spectral-domain optical coherence tomography (SD-OCT) in secondary progressive multiple sclerosis (SPMS). Objective: Document cross-sectional and longitudinal retinal nerve fiber layer (RNFL) macular ganglion cell plus inner plexiform (GCIPL) features of an SPMS clinical trial cohort. Methods: Prospective, observational study using a 2-year randomized placebo-controlled cohort with yearly SD-OCT testing. Post hoc analysis...
Since 2011, use of immune checkpoint inhibitors (ICI) in cancer immunotherapy dramatically expanded, both alone and combination with either a different treatment or two ICIs. With this increase have come myriad adverse effects from enhanced activation, including ophthalmic neurologic related events (irAE). Neuro-ophthalmic (NOirAE) associated ICIs are increasingly recognized their severity may actually limit potentially life-saving immunotherapy. NOirAEs comprise wide variety presentations...
Delayed visual maturation (DVM) is usually a retrospective diagnosis given to infants who are born with no or poor visually-directed behavior, despite normal acuity on objective testing, but recover months later. This condition can be organized into several types based associated neurodevelopmental ocular findings, the etiology of DVM probably complex and involves multiple possible origins.Here we report two presented delayed (attention). They were visually unresponsive at birth later found...
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A 62-year-old male with a history of metastatic clear cell renal carcinoma (ccRCC) presented decreased vision to 20/50 in the left eye. Fundus examination revealed an elevated, amelanotic mass lesion superotemporal macula, without involvement central macula by subretinal fluid or tumour. Given incongruity between fundus findings and degree visual impairment, field testing was obtained, revealing bitemporal hemianopia. Magnetic resonance imaging demonstrated optic chiasm compression pituitary...
Background: Giant cell arteritis (GCA) is the most common systemic vasculitis in American population older than 50 years and a sight-threatening life-threatening disease. It definitively diagnosed with temporal artery biopsy. Although there are many studies focusing on clinical presentation laboratory values diagnosing GCA general population, veteran lacking. This first study describing diagnostic features of US military veterans. METHODS: We performed retrospective chart review Veterans...
ABSTRACT Significance Intracranial hypotension is a condition that occurs from cerebrospinal fluid leak. Various visual symptoms have been associated with this condition. Cranial nerve VI (CN VI) palsies are the most common ocular manifestation, as abducens prone to injury due its intracranial anatomical course. Purpose This case report presents CN palsy secondary ventriculoperitoneal shunt over-filtration. Diagnosis, treatment, and management considerations discussed. No identifiable health...
Optic disc drusen (ODD) are present in up to 2% of the general population. The presence ODD can result vision loss. This study investigated...