A5011205445- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Chronic Kidney Disease and Diabetes
- Systemic Sclerosis and Related Diseases
- Renal and Vascular Pathologies
- Biomedical Research and Pathophysiology
- Autoimmune Bullous Skin Diseases
- Amino Acid Enzymes and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Fullerene Chemistry and Applications
- Graphene research and applications
- COVID-19 Impact on Reproduction
- Complement system in diseases
- Hydrogen's biological and therapeutic effects
- Platelet Disorders and Treatments
- Fungal Infections and Studies
- Systemic Lupus Erythematosus Research
- Carbon Nanotubes in Composites
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood groups and transfusion
- Stochastic processes and financial applications
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Digestive system and related health
- Dermatological and Skeletal Disorders
Capital Medical University
2017-2025
Beijing Anzhen Hospital
2017-2025
Weatherford College
2021
Chung Yuan Christian University
2002
Background Idiopathic membranous nephropathy (IMN) is the most common pathological type in adults with nephrotic syndrome. Many target antigens have been discovered. However, dual antigen-positive IMN patients are very rare, only a few such cases being briefly described various studies. There no specific study on clinicopathological and prognostic characteristics of patients, disease remain unclear. Methods Immunohistochemical staining PLA2R, THSD7A, NELL-1 was conducted kidney tissue...
The neural EGF-like 1 (NELL-1) protein is a novel antigen in primary membranous nephropathy. prevalence and clinical characteristics of NELL-1-positive nephropathy Chinese individuals with are unclear.A total 832 consecutive patients biopsy-proven were enrolled. glomerular expression phospholipase A2 receptor (PLA2R) thrombospondin type domain-containing 7A (THSD7A) was screened. Glomerular immunohistochemistry staining for NELL-1 performed 43 PLA2R- THSD7A-negative nephropathy, 31...
Background: This study investigated risk factors and possible mechanisms of arterial venous thromboembolic events in patients with pMN. Methods: Patients pMN confirmed by renal biopsy from June 1, 2010 to March 3, 2023 were included , the outcome was set as a composite endpoint acute coronary syndrome, heart failure, cerebral infarction, arrhythmia, pulmonary embolism, deep thrombosis all-cause mortality. Results: A total 433 complete data included, median follow-up time 73 (45.5–101.6)...
IgA nephropathy (IgAN), which has been confirmed as a complement mediated autoimmune disease, is also one form of glomerulonephritis associated with COVID-19. Here, we aim to investigate the clinical and immunological characteristics patients IgAN after The level plasma C5a (p < 0.001), soluble C5b-9 = 0.018), FHR5 0.001) were all significantly higher in Group CoV (33 renal biopsy-proven experienced COVID-19) compared non-CoV (44 without COVID-19), respectively. Compared non-CoV, intensity...
We report the case of a 49-year-old Chinese woman with nephrotic syndrome, characterized by normal kidney function but poor response to hormonal and immunosuppressive therapy, indicative steroid-resistant syndrome. Through renal biopsy, patient was diagnosed as havingfocal segmental glomerulosclerosis (perihilar type), subsequent whole-exome sequencing identified pathogenic frameshift variant concerning TBC domain
Immunoglobulin A nephropathy (IgAN) presents various clinical manifestations and pathological phenotypes. Approximately 5% of patients with IgAN present early onset nephrotic syndrome, mild mesangial lesions, diffuse foot process effacement podocytes, which resemble minimal change disease (MCD). These are defined as MCD-IgAN. Whether MCD-IgAN is a special type or simply MCD accompanied by IgA deposition remains controversial.A total 51 diagnosed at Beijing Anzhen Hospital from January 2010...
IgA nephropathy (IgAN) encompasses a wide range of clinical and histology features. Some patients present without hematuria, with or hypertension, still rapidly progress in renal function. Renal pathology this part were predominant intrarenal arteriolar lesions, rarely presented glomerular proliferative lesions. We aim to investigate the pathological characteristics prognosis these IgAN initially explore whether abnormal activation complement is involved lesions IgAN. A total 866...
The temperature dependence of dark conductivity C60 fullerites in the form polycrystalline films sandwiched between metal electrodes is systematically studied. At rotational order/disorder phase transition Tc about 256 K, an abrupt change 4–5 orders magnitude within a narrow range less than 2 K observed. for this sample decreases as crosses from fcc to sc phase. From Arrhenius plot conductivity, activation energies are estimated be 53±4 meV and 111±6 To explain these experimental findings,...
Abstract To explore the clinicopathological characteristics and prognosis of idiopathic membranous nephropathy (IMN) with focal segmental sclerosis lesions (FSL). A total 70 IMN patients FSL (FSL+group) were enrolled in this study, 140 randomly selected by age sex matching as disease controls (FSL-group). The clinical renal histopathological data on biopsy regularly followed collected. Serum anti-phospholipase A2 receptor (PLA2R) autoantibody, thrombospondin type-1 domain-containing 7A (7A)...
Since the coronavirus disease of 2019 (COVID-19) pandemic swept across world, flare immune-mediated following SARS-COV-2 infection has emerged rapidly. Previous studies have documented a growing number cases IgA nephropathy (IgAN) subsequent to COVID-19 infection. IgAN been established as complement mediated autoimmune disease. Nevertheless, characteristics clinical and immunological features in patients with after was scantily reported merited further exploration.
Diabetic kidney disease (DKD) and IgA nephropathy (IgAN) are prevalent renal diseases with a high incidence rate, the prognosis is notably poorer when these two coexist. However, it remains uncertain whether pathological changes associated DKD combined deposition (DKD-IgA deposition) linked to worsened prognosis.
The exostosin 1 and 2 (EXT1/2) complex was recently identified as a potential antigen associated with systemic autoimmunity in PLA2R-negative membranous nephropathy patients. There are currently no reports of circulating antiEXT1/2 antibodies clinical studies EXT1/2-positive the Chinese population.
Abstract Background and Aims The exostosin 1 2 (EXT1/2) complex was recently identified as a potential antigen associated with systemic autoimmunity in PLA2R-negative membranous nephropathy patients. There are currently no reports of circulating anti-EXT1/2 antibodies clinical studies EXT1/2-positive the Chinese population. Method Immunohistochemical staining for PLA2R, THSD7A NELL-1 performed 1442 consecutive patients biopsy-proven MN from January 2011 to December 2019 at Beijing Anzhen...
Abstract Background and Aims Since the coronavirus disease of 2019 (COVID-19) pandemic swept across world, flare immune-mediated following SARS-CoV-2 infection has emerged rapidly. IgA nephropathy (IgAN), which been confirmed as a complement mediated autoimmune disease, is also one common glomerulonephritis associated with COVID-19. Here, we aim to investigate clinical immunological characteristics patients IgAN after Method From December 2022 April 2023, 33 renal biopsy-proven (Group CoV)...
Abstract Background and Aims Diabetic kidney disease (DKD) IgA nephropathy (IgAN) are prevalent renal diseases with a high incidence rate, the prognosis is notably poorer when these two coexist. However, it remains uncertain whether pathological changes associated DKD combined deposition (DKD-IgA deposition) linked to worsened prognosis. Method To address this question, we conducted an analysis comparing clinicopathological characteristics of DKD-IgA patients as controls (Fig. 1). Results...
IntroductionCOVID-19 has been reported to be associated with the occurrence and recurrence of membranous nephropathy (MN). The clinicopathological characteristics complement system activation MN after COVID-19 are unclear.MethodsA total 38 patients biopsy-proven who developed new-onset proteinuria were enrolled in this study. One hundred primary diagnosed before pandemic control. Renal immunohistochemical staining for SARS-CoV-2 nucleocapsid protein was performed COVID-19. Serum membrane...
Objective To investigate whether the clinical and pathological injury of kidney in IgA nephropathy (IgAN) patients with hypertension is associated circadian blood pressure rhythm change, particularly elevated nocturnal (BP). Methods This study was a retrospective cross-sectional study. Clinic renal histopathological data were obtained from 83 IgAN hypertension. First, 24 h ambulatory BP monitoring (ABPM) analyzed. Second, all these divided into two groups, group normotensive group,...
Primary membrane nephropathy (PMN) and IgA (IgAN) are the most common glomerular diseases in China. Because of different pathogenesis, prognosis is significantly different. When two coexist (PMN/IgAN), clinicopathological manifestations remain unclear. In present study, we analyzed characteristics PMN/IgAN patients, with only deposition (PMN/IgA deposition) patients as controls. Galactose-deficient IgA1(KM55) M-type Phospholipase A2 Receptor(PLA2R), both circulation renal tissues, were...