A5037558159- Genomics and Chromatin Dynamics
- Developmental Biology and Gene Regulation
- Cancer-related molecular mechanisms research
- Toxoplasma gondii Research Studies
- Antimicrobial Peptides and Activities
- Ubiquitin and proteasome pathways
- Venomous Animal Envenomation and Studies
- interferon and immune responses
- Hippo pathway signaling and YAP/TAZ
Montreal Clinical Research Institute
2022-2024
Université de Montréal
2022-2024
University of Geneva
2020-2021
Significance Reptiles exhibit a spectacular diversity of skin colors generated by interactions among black melanophores, red and yellow xanthophores, as well iridophores producing structural colors. Here, we use the corn snake to investigate generative mechanisms beyond zebrafish model. We perform sequencing annotation nearly chromosome-quality genome snake, followed mapping-by-sequencing identification mutation in lysosomal trafficking regulator gene ( LYST ) lavender variant with strongly...
Abstract Developmental genes are frequently controlled by multiple enhancers sharing similar specificities. As a result, deletions of such regulatory elements have often failed to reveal their full function. Here, we use the Pitx1 testbed locus characterize in detail and cellular identity alterations following deletion one its ( Pen ). By combining single cell transcriptomics an in-embryo tracing approach, observe increased fraction non/low-expressing cells decreased high-expressing cells....
Abstract Most developmental genes rely on multiple transcriptional enhancers for their accurate expression during embryogenesis. Because may have partially redundant activities, the loss of one them often leads to a partial gene and concurrent moderate phenotypic outcome, if any. While such phenomenon has been observed in many instances, nature underlying mechanisms remains elusive. We used Pitx1 testbed locus characterize detail regulatory cellular identity alterations following deletion...