A5059967888- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Genomic variations and chromosomal abnormalities
- Esophageal Cancer Research and Treatment
- Vasculitis and related conditions
- Cancer Cells and Metastasis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Diverticular Disease and Complications
- Digestive system and related health
- MicroRNA in disease regulation
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Cancer-related gene regulation
Iwate Medical University
2015-2024
Japanese Red Cross Hadano Hospital
2022-2023
Iwate Prefectural Central Hospital
2021-2022
The Japanese Society of Gastroenterological Surgery
2020
Showa University
2020
Showa University Koto Toyosu Hospital
2020
Jikei University School of Medicine
2020
DNA Diagnostic (Denmark)
2018
ABSTRACT Background Three Janus kinase (JAK) inhibitors are approved for ulcerative colitis (UC) in Japan. Aim To compare the real‐world efficacy and safety of these three JAK UC. Methods This was a multicentre, retrospective study patients with UC started on inhibitors. The primary outcome clinical remission at 10, 26 58 weeks, most recent follow‐up. among inhibitors, we created matched cohorts (upadacitinib vs. filgotinib, tofacitinib filgotinib upadacitinib tofacitinib) using propensity...
Two molecular pathways promote the development of colorectal cancer (CRC). One is termed "microsatellite stable" (MSS) whereas other characterized by instability" (MSI or MIN). In addition, CpG island methylation phenotype known to be an important alteration as a third type. Thus, DNA thought provide potential biomarkers for assessment risk in normal mucosa. it also that colonic location parameter CRC. We examined surrounding mucosa three parts colon. Next, we quantified levels SFRP1, SFRP2,...
Differences in the pathogenesis of microsatellite stable (MSS) sporadic colorectal cancers (CRCs) between left-sided CRC (LC) and right-sided (RC) have not been clarified. To identify pathogenesis-related genomic differences MSS CRCs within two locations, we performed a comprehensive molecular analysis using crypt isolation with samples from 92 CRCs. Microsatellite instability (MSI; high low/negative) DNA methylation status (low epigenome; intermediate epigenome [IME] or [HME]) were...
The relevance of the clinicopathological and molecular features early gastric cancers (EGCs) having microsatellite instability (MSI)‐high phenotype has not been clearly defined in sporadic carcinogenesis. Here, we examined characteristics EGC according to MSI status 330 patients with (intestinal‐type adenocarcinoma). Tumors were classified as MSI‐high (45 cases), MSI‐low (9 or stable (MSS; 276 cases). specimens using a combination polymerase chain reaction (PCR)‐microsatellite assays...
To better understand progressive changes in gastric cancer (GC), early and advanced GCs (EGC AGC, respectively) were examined for copy number alterations (CNAs). A crypt isolation method was used to isolate DNA from tumors normal glands 20 AGCs, fresh tumor samples obtained 45 EGCs. We assessed CNAs differentiated-type using an Infinium HumanCytoSNP-12v2.1 BeadChip EGCs AGCs. The most frequent aberrations EGC gains at 8q23.3 (42.2%) 8q23.2 (40%), loss of heterozygosity (LOH) 3p14.2 (24.2%),...
We aimed to investigate an association between clinicopathological features, including immunohistochemical mucin phenotypes, and magnifying chromoendoscopic findings with crystal violet staining (ME-CV) in non-ampullary duodenal epithelial tumors (NADETs).A total of 55 patients NADET were divided into 3 groups by phenotype: intestinal, gastrointestinal, or gastric. ME-CV classified 4 patterns: convoluted, leaf-like, reticular/sulciolar, pinecone. The features compared among the...
Recent studies have shown that the microenvironment can include cancer cells and cancer-associated fibroblasts (CAFs), both play important roles in progression metastasis of CRC. Here, we aimed to analyse expression patterns cell- CAF-related proteins submucosal invasive colorectal (SiCRC) whether such markers are correlated with lymph node (LNM).Quantitative analysis was conducted for Ki-67, p53, β-catenin matrix metalloproteinase-7 (MMP7) assess cell markers. In addition, examined CAF...
// Hironori Aoki 1, * , Eiichiro Yamamoto 2, Akira Takasawa 3 Takeshi Niinuma 1 Hiro-O Yamano 2 Taku Harada Matsushita 4 Kenjiro Yoshikawa Ryo Takagi Eiji Yoshihito Tanaka Yuko Yoshida Tomoyuki Aoyama Makoto Eizuka 5 Yorozu Hiroshi Kitajima Masahiro Kai Norimasa Sawada Tamotsu Sugai Nakase and Hiromu Suzuki Department of Molecular Biology, Sapporo Medical University School Medicine, Sapporo, Japan Gastroenterology Hepatology, Pathology, Digestive Disease Center, Akita Red Cross Hospital,...
Objective: Recent studies have shown that cancer-associated fibroblasts (CAFs) and the epithelial-mesenchymal transition (EMT) play important roles in progression metastasis of CRC.Although prediction lymph node submucosal invasive colorectal cancer (SiCRC) is important, relationships CAF EMT with SiCRC not yet been examined.Here, we aimed to analyze expression patterns CAF-and EMT-related proteins SiCRC. Materials Methods:The CAF-related markers, including α-smooth muscle actin, CD10,...
Background/Aims We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS). The aim this study was to evaluate protein expression intestinal tissues patients CEAS, Behçet's disease (BD), simple ulcer (SU), and Crohn's (CD). Methods Immunohistochemical staining using a polyclonal anti-SLCO2A1 antibody performed on resected specimens from 13 cases CD, 9...
Gastric mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are infrequently encountered in routine practice. Some gastric neuroendocrine carcinomas (NECs) have a variety of differentiation patterns; however, pancreatic acinar NECs is rare. The molecular abnormalities with not well understood. A 67-year-old male MiNEN without any symptoms. tumor consisted two components, including both glandular and solid histological features. Although the former component was common type...
We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim this study was to investigate gastroduodenal expression SLCO2A1 protein patients CEAS and Crohn's disease (CD).Immunohistochemical staining for performed a polyclonal antibody, HPA013742, on tissues obtained by endoscopic biopsy from...
Object: The aim of the present study was to investigate clinicopathological characteristics and prognostic factors associated with sporadic colorectal cancer (CRC). We examined findings immunohistochemical expression tumor markers at budding sites determine their predictive value for patient prognosis. Materials Methods: Immunohistochemical examination performed by tissue microarray (TMA) specimens from 106 patients CRC. On hematoxylin eosin (H&E)-stained slides, a representative area...
Abstract Gastric intraepithelial foveolar type neoplasia (IEFN) is not well defined. In addition, atrophic mucosa (AM) an important issue to consider when evaluating gastric tumorigenesis. Here, we assessed the clinicopathological characteristics and molecular alterations contributing development of IEFN compared with intestinal neoplasia. We examined features 42 cases low-grade dysplasia (LGD) those 77 (IEIN) LGD. The included AM status, mucin phenotype expression, CDX2 p53 overexpression,...
Abstract Background and study aims Among vasculitides, IgA vasculitis (IgAV) eosinophilic granulomatosis with polyangiitis (EGPA) frequently damage the gastrointestinal tract. However, only a few studies have investigated entire tract in patients IgAV or EGPA by endoscopy. The aim of this was to clarify endoscopic characteristics those EGPA. Patients methods Clinicopathological findings were retrospectively compared between 33 19 Results Gastrointestinal involvement observed (100 %) 8 EPGA...
Abstract Background Recent studies have shown that traditional serrated adenoma (TSA) can be classified into BRAF and KRAS subtypes. Here, we examined the clinicopathological molecular findings of 73 TSAs. Materials methods TSAs were subclassified type (46 cases, A) (27 B) divided polyp head (TSA component) base (precursor component [PC]) to identify pathological differences between two components. mutations, microsatellite instability (MSI), DNA methylation status TSA PC analyzed. In...
Underwater endoscopic mucosal resection (U-EMR) has been attracting much attention as treatment for patients with nonampullary duodenal epithelial tumors (NADETs). We aim to compare outcomes, including submucosal resectability, between undergoing U-EMR and conventional (C-EMR) NADET.We conducted a retrospective review of 38 NADET treated by or C-EMR. In the resected specimens, we measured horizontal length, vertical distance from muscularis mucosa margin at deepest site, overall area. The...
Tumor tissue consists of a heterogeneous cell population. The allelic imbalance ( AI ) ratio, determined in isolated tumor glands, is good index heterogeneity. However, associations the patterns and microsatellite instability MSI development, observed most cases colorectal cancer CRC ), with progression have not been reported previously. In this study, we examined whether genetic profiles stratified by combination ratio facilitate categorization , these are associated specific molecular...
The aim of your study is to characterize serrated lesions according their molecular patterns, specifically BRAF/KRAS mutation, methylation, and microsatellite statuses. We evaluated the patterns 163 lesions, including 37 microvesicular hyperplastic polyps, 73 sessile adenomas/polyps (SSA/Ps), 31 traditional adenomas, 22 SSA/Ps with cytological dysplasia/adenocarcinoma. Mutations in BRAF (V600E)/KRAS (exon 2) status [microsatellite stability (MSS) vs. MSI] were examined using a pyrosequencer...