A5074222770- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Electrohydrodynamics and Fluid Dynamics
- Colorectal Cancer Surgical Treatments
- Atomic and Molecular Physics
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- High voltage insulation and dielectric phenomena
- Plasma Diagnostics and Applications
- Microfluidic and Bio-sensing Technologies
- Ionosphere and magnetosphere dynamics
- Microfluidic and Capillary Electrophoresis Applications
- RNA modifications and cancer
- Engineering Applied Research
- Lung Cancer Treatments and Mutations
Keiyukai Sapporo Hospital
2024-2025
Sapporo Medical University
2014-2024
Teine Keijinkai Hospital
2012-2023
Hokkaido hospital
2021-2023
Tokyo City University
2020-2022
Osaka University
1993-2017
University of York
2017
Kyushu University
2017
Akita Red Cross Hospital
2014
Suzuki (Japan)
2014
We investigated the time evolution of a strong collisionless shock in counterstreaming plasmas produced using high-power laser pulse. The were generated by irradiating CH double-plane target with laser. In self-emission streaked optical pyrometry data, steepening profile as two-plasma interaction evolved indicated formation. thickness was less than mean free path ions. Two-dimensional snapshots and shadowgrams also showed very thin structures. Mach numbers estimated from flow velocity...
Radio-frequency glow-like plasmas have been produced in Ar bubbles water that flows a quartz tube equipped with electrodes. Plasmas bubbles, (or 'bubble plasmas' short) may be used to induce some specific chemical reactions liquids. It has demonstrated bubble can decompose methylene blue (MB) dissolved and hydroxyl (OH) radicals are present the gas-phase plasmas. Therefore it presumed decomposition of MB is caused either directly by OH generated diffuse into aqueous solution or indirectly...
The experimental demonstration of the formation a strong electrostatic (ES) collisionless shock has been carried out with high-speed counterstreaming plasmas, produced by high-power laser irradiation, without external magnetic field. nearly four times density jump observed in experiment shows high Mach-number shock. This large is attributed to compression downstream plasma momentum transfer ion reflection upstream plasma. Particle-in-cell (PIC) simulation production ES interaction two slabs...
Aberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms. In this study, we assessed the feasibility of using detected in bowel lavage fluid (BLF) cancer screening. A total 508 BLF specimens were collected from patients with (n = 56), advanced adenoma 53), minor polyp 209), and healthy individuals 190) undergoing colonoscopy. Methylation 15 genes (miR-1-1, miR-9-1, miR-9-3, miR-34b/c, miR-124-1, miR-124-2, miR-124-3, miR-137, SFRP1, SFRP2, APC, DKK2, WIF1,...
Diacylglycerol kinases (DGKs) are important regulators of cell signaling and have been implicated in human malignancies. Whether epigenetic alterations involved the dysregulation DGKs cancer is unknown, however. We therefore analyzed methylation promoter CpG islands DGK genes colorectal (CRC) lines. found that DGKG , which encodes DGKγ, was hypermethylated all CRC lines tested ( n = 9), but not methylated normal colonic tissue. Correspondingly, expression suppressed tissue, restored cells by...
Abstract Objectives Although a novel submucosal injection material consisting of fully synthetic, self‐assembling peptide solution, PuraLift, has recently become commercially available in Japan, there are few reports regarding the usefulness this solution. The aim study was to investigate feasibility PuraLift for conventional endoscopic mucosal resection (EMR) clinical practice. Methods This multicenter retrospective conducted at endoscopy units five institutions from January 2023 May 2023....
ABSTRACT Despite increasing reports of hepatitis B virus (HBV) reactivation in hematological malignancies, its incidence, and risk factors are still obscure. The aim this study was to clarify the frequency HBV surface antigen (HBsAg) undetectable patients with malignant lymphoma or multiple myeloma, during after chemotherapy. A total 109 HBsAg undergoing chemotherapy for myeloma were enrolled study. Anti‐hepatitis (anti‐HBs) anti‐hepatitis core (anti‐HBc) checked before treatment, DNA sera...
A temperature sensor that uses temperature-sensitive fluorescent dyes is developed. The droplet has a diameter of 40 µm and 1 g/L Rhodamine B (RhB) 0.5 110 (Rh110), which are dissolved in an ionic liquid (1-ethyl-3-methylimidazolium ethyl sulfate) to function as indicators. This encapsulated using vacuum Parylene film deposition (which known the Parylene-on-liquid-deposition (PoLD) method). sealed by chemically stable impermeable film, prevents dye from interacting with molecules solution...
Atmospheric-pressure plasmas were produced on the surface of liquid water by radio-frequency (RF) power supply. A quartz chamber with an off-center inner electrode was used to generate discharges a wide range filling gas pressures. When filled fuel and sufficient RF supplied system, observed be around as well surface. Optical emission spectroscopy (OES) identified generation oxidative hydroxyl (OH) radicals decoloration methylene blue in solution demonstrated capacity generated this system.
To evaluate the feasibility of real-time virtual needle tracking system for percutaneous radiofrequency ablation (RFA) hepatocellular carcinoma (HCC).An electromagnetic field created by an ultrasound (US) machine detected bracket mounted onto RFA needle. When tip was confirmed to be in accurate plane extracorporeally, inserted into liver using navigation US system, and performed. Eight patients with eight lesions underwent under HCC from October November 2012 (VirtuTRAX).The average size...
// Hironori Aoki 1, * , Eiichiro Yamamoto 2, Akira Takasawa 3 Takeshi Niinuma 1 Hiro-O Yamano 2 Taku Harada Matsushita 4 Kenjiro Yoshikawa Ryo Takagi Eiji Yoshihito Tanaka Yuko Yoshida Tomoyuki Aoyama Makoto Eizuka 5 Yorozu Hiroshi Kitajima Masahiro Kai Norimasa Sawada Tamotsu Sugai Nakase and Hiromu Suzuki Department of Molecular Biology, Sapporo Medical University School Medicine, Sapporo, Japan Gastroenterology Hepatology, Pathology, Digestive Disease Center, Akita Red Cross Hospital,...
Plasma jet formation was observed in counterstreaming plasmas a laboratory experiment. In order to model an ambient plasma of astrophysical jets, the were created by irradiating double CH-plane target with high-power laser system. Since mean free paths ions terms motion larger than scale length experiment, two-stream interaction essentially collisionless. The time evolution collimation obtained over several shots different timing shadowgraphy. When single irradiated, no observed. as is...
Abstract Background Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 frequently methylated traditional adenomas (TSAs) and cancers (CRCs) but rarely sessile lesions (SSLs). In present study, we aimed to further characterize expression early Methods was analyzed immunohistochemically a series tumors ( n = 199) adjacent normal colonic tissues 112). Results abundantly expressed colon SSLs while it significantly...
Aim To evaluate the feasibility of fusion conventional imaging modalities to facilitate assessment ablative margin radiofrequency ablation ( RFA ) hepatocellular carcinoma HCC ). Methods Two hundred and thirty‐nine liver lesions in 109 patients underwent percutaneous under ultrasound for from J anuary 2008 D ecember 2010. Within these patients, 13 12 who developed local tumor progression follow‐up period at least 8 months were retrospectively reviewed. Imaging obtained before after was used...
We report our recent efforts on the experimental investigations related to origins of cosmic rays. The rays are long standing open issues in astrophysics. galactic and extragalactic considered be accelerated non-relativistic relativistic collisionless shocks universe, respectively. However, acceleration transport processes not well understood, how created is still under investigation. Recent high-power high-intensity laser technologies allow us simulate astrophysical phenomena laboratories....
Aberrant DNA methylation is commonly observed in colorectal cancer (CRC), but the underlying mechanism not fully understood. 5-hydroxymethylcytosine levels and TET1 expression are both reduced CRC, while epigenetic silencing of reportedly associated with CpG island methylator phenotype. In present study, we aimed to clarify relationship between loss aberrant CRC. Stable knockdown clones were established using Colo320DM cells, which express high TET1, HCT116 at a level similar that normal...
AIM:To investigate insulin-like growth factor 2 (IGF2 ) differentially methylated region (DMR)0 hypomethylation in relation to clinicopathological and molecular features colorectal serrated lesions. METHODS:To accurately analyze the association between histological types of each type lesion, we consecutively collected 1386 formalin-fixed paraffin-embedded tissue specimens that comprised all [hyperplastic polyps (HPs, n = 121), sessile adenomas (SSAs, 132), traditional (TSAs, 111),...
Background and study aims We previously reported on a novel traction method called Multiloop (M-loop) for faster colorectal endoscopic submucosal dissection (ESD). In this study, we retrospectively compared the difference in time (SDT), speed (SDS) between groups of patients who were treated using with M-loop method, non-traction methods ESD. Patients reviewed timed duration ESD by from videos recorded June 2016 December 2017. From January 2018 onward, used during all ESDs it until August...
Abstract Submucosal invasion and lymph node metastasis are important issues affecting treatment options for early colorectal cancer (CRC). In this study, we aimed to unravel the molecular mechanism underlying invasiveness of CRCs. We performed RNA‐sequencing (RNA‐seq) with poorly differentiated components (PORs) their normal counterparts isolated from T1 CRC tissues detected significant upregulation serum amyloid A1 (SAA1) in PORs. Immunohistochemical analysis revealed that SAA1 was...
To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed DNA methylation cancer-associated genes in a cohort BRAF-mutant precancerous lesions from 94 individuals. We then compared those results with lesions' features, especially subsites. The included hyperplastic polyps (n = 16), traditional adenomas (TSAs) 15), TSAs sessile (SSAs) 6), SSAs 49) dysplasia 16). prevalence exhibiting CpG island methylator phenotype (CIMP) was lower sigmoid...