A5008477927- Congenital Anomalies and Fetal Surgery
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Non-Destructive Testing Techniques
- RNA and protein synthesis mechanisms
- High voltage insulation and dielectric phenomena
- Power Transformer Diagnostics and Insulation
- Advanced Electrical Measurement Techniques
- Genomics and Phylogenetic Studies
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Magnetic Properties and Applications
- Evolution and Genetic Dynamics
- Forest Insect Ecology and Management
- Molecular Biology Techniques and Applications
- Sensor Technology and Measurement Systems
- Gun Ownership and Violence Research
- Pancreatic function and diabetes
- Fault Detection and Control Systems
- Diet and metabolism studies
- Policing Practices and Perceptions
University of New Mexico
2025
Massachusetts Institute of Technology
2017-2023
General Electric (Argentina)
1922
Slow progress in the fight against neurodegenerative diseases (NDs) motivates an urgent need for highly controlled vitro systems to investigate organ-organ- and organ-immune-specific interactions relevant disease pathophysiology. Of particular interest is gut/microbiome-liver-brain axis parsing out how genetic environmental factors contribute NDs. We have developed a mesofluidic platform technology study gut-liver-cerebral context of Parkinson's (PD). It connects microphysiological (MPSs)...
Cancer is partly a developmental disease, with malignancies named based on cell or tissue of origin. However, systematic atlas tumor origins lacking. Here we map the single-cell organogenesis 56 trajectories to transcriptomes over 10,000 tumors across 33 cancer types. We deconvolute into signals for individual trajectories. Using these as inputs, construct multilayer perceptron (D-MLP) classifier that outputs D-MLP (ROC-AUC: 0.974 top prediction) outperforms benchmark classifiers. analyze...
ABSTRACT The beetle family Ptinidae contains a number of economically important pests, such as the cigarette Lasioderma serricorne , drugstore Stegobium paniceum and diverse spider beetles. Many these species are stored product which target range food sources, from dried tobacco to books made with organic materials. Despite threat that 2,200 beetles pose, fewer than 50 have been surveyed for microbial symbionts, only handful screened using contemporary genomic methods. In this study, we...
Advances in next-generation sequencing technologies have allowed RNA to become an increasingly time efficient, cost-effective, and accessible tool for genomic research. We present here automated miniaturized workflow library preparation that minimizes reagent usage processing required per sample generate Illumina compatible libraries sequencing. The reduced-volume show similar behavior full-scale with comparable numbers of genes detected reproducible clustering samples.
Introduction Great accuracy in the high tension testing of insulating materials is not yet attainable, due to variability materials, difficulty exactly controlling all conditions test, and many cases, unreliability apparatus methods employed.
Abstract The beetle family Ptinidae contains a number of economically important pests, such as the Cigarette Lasioderma serricorne , Drugstore Stegobium paniceum and diverse Spider beetles. Many these species are stored product pests which target range food sources from dried tobacco to books made with organic materials. Despite threat that 2,200 beetles pose, fewer than 50 have been surveyed for microbial symbionts, only handful screened using contemporary genomic methods. In this study, we...
Detection of genomic changes at single cell resolution is important for characterizing genetic heterogeneity and evolution in normal tissues, cancers, microbial populations. Traditional methods assessing have been limited by low resolution, sensitivity, and/or specificity. Single sequencing has emerged as a powerful tool detecting with high sensitivity and, when appropriately analyzed, Here we provide protocol the isolation, whole genome amplification, sequencing, analysis cells. Our...
FOR EXACT determination of the high-tension voltage in testing transformers, an auxiliary winding few turns placed on same core and connected to accurate voltmeter has been used with success.
The item of the greatest moment in this work is fact that for first time history world extremely high power potential a million and half volts (over 2,000,000 peak value) was reached an electric spark discharge repeatedly caused to take place between sharp electrodes spaced fourteen feet apart. No damage done equipment. This marks remarkable accomplishment. A pertinent question — what it? modern physicist chemist who are trying realize ancient alchemist's dream transforming one element into...
THE design and construction of the three 500-kw., 578,000-volt transformers 500-kw. insulating transformer were given in Part I this paper <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> , which included also illustrations single-phase arcs between sharp points, spaced 9, 11 14 ft. apart corresponding to crest voltages sine potential waves having effective values approximately 1,000,000, 1,200,000 1,500,000 volts.
Detection of genomic changes at single cell resolution is important for characterizing genetic heterogeneity and evolution in normal tissues, cancers, microbial populations. Traditional methods assessing have been limited by low resolution, sensitivity, and/or specificity. Single sequencing has emerged as a powerful tool detecting with high sensitivity and, when appropriately analyzed, Here we provide protocol the isolation, whole genome amplification, sequencing, analysis cells. Our...
Abstract Cancer is a disease manifesting in abrogation of developmental programs, and malignancies are named based on their cell or tissue origin. However, systematic atlas tumor origins lacking. Here we map the single organogenesis 56 trajectories to transcriptomes over 10,000 tumors across 33 cancer types. We use this deconvolute individual into constituent trajectories. Based these deconvoluted construct Developmental Multilayer Perceptron (D-MLP) classifier that outputs The D-MLP...
<div>Abstract<p>Cancer is partly a developmental disease, with malignancies named based on cell or tissue of origin. However, systematic atlas tumor origins lacking. Here we map the single-cell organogenesis 56 trajectories to transcriptomes over 10,000 tumors across 33 cancer types. We deconvolute into signals for individual trajectories. Using these as inputs, construct multilayer perceptron (D-MLP) classifier that outputs D-MLP (ROC-AUC: 0.974 top prediction) outperforms...
<div>Abstract<p>Cancer is partly a developmental disease, with malignancies named based on cell or tissue of origin. However, systematic atlas tumor origins lacking. Here we map the single-cell organogenesis 56 trajectories to transcriptomes over 10,000 tumors across 33 cancer types. We deconvolute into signals for individual trajectories. Using these as inputs, construct multilayer perceptron (D-MLP) classifier that outputs D-MLP (ROC-AUC: 0.974 top prediction) outperforms...
Supplementary Figure from Developmental Deconvolution for Classification of Cancer Origin