A5001598703- Stress Responses and Cortisol
- Diet and metabolism studies
- Natural product bioactivities and synthesis
- Birth, Development, and Health
- Essential Oils and Antimicrobial Activity
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Semiconductor materials and interfaces
- Nerve injury and regeneration
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Nanoparticles: synthesis and applications
- Antimicrobial Peptides and Activities
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Thyroid Disorders and Treatments
- Toxin Mechanisms and Immunotoxins
- Veterinary medicine and infectious diseases
- Phytochemistry and Bioactivity Studies
- Inflammasome and immune disorders
- Neonatal and fetal brain pathology
- Effects of Environmental Stressors on Livestock
- Bioactive Compounds and Antitumor Agents
- Neurogenesis and neuroplasticity mechanisms
- Menstrual Health and Disorders
Maj Institute of Pharmacology
2012-2020
Polish Academy of Sciences
1972-2020
Caerus Molecular Diagnostics (United States)
2018
KU Leuven
2018
Sichuan University
2018
University of Freiburg
2018
The University of Queensland
2018
Concordia University
2018
Virginia Commonwealth University
2018
Wuhan University
2018
Abstract Bacterial resistance to antibiotics is increasing at an alarming rate and many commonly used are no longer effective. Thus, there considerable interest in investigating novel antibacterial compounds, such as the plant-derived pentacyclic triterpenoids, including oleanolic acid (OA), ursolic (UA) their derivatives. These compounds can be isolated from medicinal crop plants antibacterial, antiviral, antiulcer anti-inflammatory effects well documented. OA UA active against bacterial...
Studies on new antibacterial therapeutics and strategies are currently being conducted in many microbiological, pharmaceutical biochemical laboratories. The activity of plant-derived compounds as well silver gold nanoparticles is the subject this minireview. application photodynamic therapy also discussed.
The antibacterial and antiparasitic activities of free oleanolic acid its glucosides glucuronides isolated from marigold (Calendula officinalis) were investigated. MIC the effect on bacterial growth estimated by A600 measurements. Oleanolic acid's influence survival ability to induce autolysis measured counting number cfu. Cell morphology presence endospores observed under electron light microscopy, respectively. inhibited survival, influenced cell enhanced Gram-positive bacteria suggesting...
Due to the alarming spread of resistance classic antimicrobial agents, innovative therapeutic methods combat antibiotic-resistant bacterial pathogens are urgently required. This minireview examines enhancement antibiotic efficacy by their combination with new antimicrobials, such as plant-derived compounds, metal ions and nanoparticles bacteriophage lytic enzymes. The mechanisms observed synergy also described. promising results basic research indicate that in future, combined therapy may be...
<b><i>Introduction:</i></b> Recent data indicate that there is a link between depression and diabetes excess glucocorticoids may play an underlying role in the pathogenesis of both these diseases. The aim present study was to determine whether are any alterations glucose, glycogen, glucose transporters, insulin, insulin receptors or corticosterone concentrations hippocampus frontal cortex prenatal stress rat model depression....
Although hypothyroidism appears to be an important factor in the pathogenesis of depression, impact thyroid hormones on bioenergetics adult brain is still poorly known. Since metabolic changes are reported a key player manifestation depressive disorder, we investigated whether there differences selected markers frontal cortex and hippocampus Wistar Kyoto rats (WKY; animal model depression) compared those control induction by propylthiouracil (PTU) elicits similar effects these animals or...
Current data suggest an important role of brain metabolic disturbances in the pathogenesis depression and obesity, diseases that frequently co-occur. Our aim was to determine whether there are changes markers characterizing glucose metabolism prenatal stress (PS; animal model depression), rats fed a high-fat diet (HFD), especially obesity co-occurrence. The glucose-6-phosphate, glycogen, transporters (GLUT1, GLUT4), glucagon-like peptide-1 receptor (GLP-1R), mitochondrial complexes levels...
Elevated levels of glucocorticoids exert neurotoxic effects, and the hippocampus is particularly sensitive to effects glucocorticoids. Because some data have indicated that an increased action in perinatal period enhances susceptibility brain tissue adverse substances later life, main purpose present study was compare necrotic/apoptotic corticosterone hippocampal organotypic cultures obtained from control animals with effect this steroid prenatally stressed rats. glucocorticoid on nerve cell...
Oleanolic acid and ursolic are pentacyclic triterpenoids isolated from a variety of medicinal plants, which have antibacterial activity. Listeria monocytogenes is Gram-positive facultative pathogen, being the causative agent listeriosis. The present study was carried out to evaluate in vitro effect sub-inhibitory concentrations both triterpene acids on pathogenicity determinants L. monocytogenes: their hemolytic activity biofilm forming ability. inhibited listeriolysin O without influencing...
Gestational diabetes is a disorder associated with abnormal chronic inflammation that poses risk to the developing fetus. We investigated effects of experimentally induced (streptozotocin model) in Wistar female rats on inflammatory status hippocampi their offspring. Additionally, impact antidiabetic drugs (metformin and glyburide) processes was evaluated. Organotypic hippocampal cultures (OHCs) were prepared from brains 7-day-old rat offspring control diabetic mother rats. On 7th day vitro,...
Transition from round budding cells to long hyphal forms and production of secreted aspartic proteases (Saps) are considered virulence-associated factors Candida albicans. Although plenty data dealing with Saps involvement in the infection process have been published, expression by different pleomorphic as well capacity C. albicans filaments express Sap1-6 under serum influence poorly investigated. In this study, we used immunofluorescence immunoelectron microscopy for detection isoenzymes...
Obesity is a disease that often co‐occurs with depression and there some evidence to indicate chronic stress in the perinatal period, association overactive glucocorticoids, can cause permanent changes increase risk of development both obesity later life. However, mechanism responsible for overly potent action glucocorticoids not known. The present study aimed determine expression glucocorticoid receptors (GRs) mineralocorticoid (MRs) factors affect GR function (FKBP51, Bag‐1 HSP70) prenatal...
Herbicides are used in large amounts agriculture and the evaluation of their toxic effects is major concern to environmental safety. The aim present study was investigate common carp hematological alterations caused by herbicide exposure. Fish were treated with pendimethalin ethofumesate tested separately mixture administered aquarium water. Peripheral blood fish collected after 1, 3 7 days exposure compared control. total number erythrocytes (RBC), leukocytes (WBC), hematocrit value (Hct),...