A5053855317- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Cancer Treatment and Pharmacology
- Gestational Trophoblastic Disease Studies
- Polyomavirus and related diseases
- Reproductive System and Pregnancy
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Medical Imaging Techniques and Applications
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Gyrotron and Vacuum Electronics Research
Sunnybrook Health Science Centre
2024
Health Sciences Centre
2024
University of Toronto
2024
Clinica Universidad de Navarra
2021
Instituto do Câncer do Estado de São Paulo
2019-2020
AC Camargo Hospital
2017-2019
Hyperactivation of mTOR pathway and angiogenesis have been implicated in the pathogenesis neuroendocrine tumors (NETs). Everolimus, an oral inhibitor mTOR, sunitinib, antiangiogenic drug, are effective targeted therapies approved to treat locally advanced/metastatic pancreatic (pNETs). Most pNETs sporadic mutations genes involved directly or indirectly regulation implicated, including somatic mutation MEN1 44% cases. About 10% can be part hereditary syndromes, e.g., multiple endocrine...
The background to this study was that factors associated with carcinoid heart disease (CHD) and its impacts on overall survival (OS) are scantly investigated in patients (pts) neuroendocrine tumors (NETs). In terms of materials methods, a retrospective multicenter cohort conducted CHD advanced NET pts syndrome (CS) and/or elevated urinary 5-hidroxyindole acetic acid (u5HIAA). defined as at least moderate right valve alterations. results were the following: Among 139 subjects included,...
<b><i>Introduction:</i></b> The incidence of infections is poorly studied in patients with neuroendocrine tumors (NET) treated everolimus outside clinical trials. We aimed to evaluate the frequency and risk factors for opportunistic (Opl) or any serious infection eligible patients. <b><i>Methods:</i></b> This was a retrospective multicenter study Latin American cohort consecutive advanced NET everolimus. Duration everolimus, comorbidities,...
There is interest in optimizing peptide receptor radionuclide therapy (PRRT) for the management of metastatic neuroendocrine neoplasms (NEN). The addition stereotactic body radiation (SBRT) may provide synergistic benefits by targeting specific sites disease that represent areas tumor heterogeneity. Little known about efficacy or potential toxicity this approach; understanding outcomes patients treated with these two modalities a sequential fashion will insights into appropriateness...
ABSTRACT Introduction: To evaluate the safety and efficacy of hepatic transarterial embolization (TAE) or chemoembolization (TACE) in patients with irresectable liver metastases from neuroendocrine tumors (NETs) treated at two Brazilian cancer centers. Methods: Retrospective multicenter analysis (pts) histological diagnosis tumor any origin unresectable measurable who underwent least one procedure TAE TACE. Endpoints: Hepatic progression free survival (HPFS), overall (OS), response toxicity...
160 Background: Gastric cancer (GC) is one of the most frequent malignancies in developing countries. In Peru, it fourth incident cancer, and sixth Brazil. Mortality still high. The chance relapse patients with non-metastatic disease undergoing surgery more than 50%. It suspected that Latin American present worse evolution compared to those treated Asia or developed countries, therefore fundamental study factors related prognosis GC our continent. We aimed evaluate outcome adjuvant treatment...
e16101 Background: Gastric cancer (GC) is the fourth most incident in Peru, and sixth one Brazil. Mortality still high these developing countries. The chance of relapse patients diagnosed with non-metastatic disease undergoing surgery more than 50%. It suspected that Latin American present worse evolution compared to treated Asia or developed countries, therefore it fundamental study factors related prognosis GC our continent. We aimed evaluate efficacy adjuvant treatment for Stage III from...
INTRODUCTION: To evaluate the safety and e?cacy of hepatic transarterial embolization (TAE) or chemoembolization (TACE) in patients with irresectable liver metastases from neuroendocrine tumors (NETs) treated at two Brazilian cancer centers. METHODS: Retrospective multicenter analysis (pts) histological diagnosis tumor any origin unresectable measurable who underwent least one procedure TAE TACE. ENDPOINTS: Hepatic progression free survival (HPFS), overall (OS), response toxicity assessment....
Carcinoid heart disease (CHD) is a rare and severe complication from carcinoid syndrome which may be associated with high health resource utilisation (HRU). We aimed to compare HRU between patients without CHD.Multicentre retrospective study of 137 consecutive neuroendocrine tumours (NET) elevated urinary 5-hydroxyindoleacetic acid treated in seven large hospitals Latin America. used the chi-squared test for binary variables Mann-Whitney quantitative correlations. Variables were entered into...
<h3>Introduction/Background*</h3> After the LACC trial, SUCCOR study and other studies, we know that patients who have undergone Minimally Invasive Surgery for cervical cancer worse outcomes, but today really don't if surgical approach can be a reason to change pattern of relapses on these patients. We would try evaluate relapse in with Ib1 FIGO 2009 underwent radical hysterectomy different approaches. <h3>Methodology</h3> Systematic review literature was performed PubMed, Cochrane Library,...