A5086610499- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Esophageal Cancer Research and Treatment
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Head and Neck Cancer Studies
- Pancreatitis Pathology and Treatment
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Palliative Care and End-of-Life Issues
Centro de Pesquisas Oncológicas
2022-2025
AC Camargo Hospital
2014-2023
Universidade de São Paulo
2018
Instituto do Câncer do Estado de São Paulo
2018
To better understand the immune microenvironment of pancreatic ductal adenocarcinomas (PDACs), here we explored relevance T and B cell compartmentalisation into tertiary lymphoid structures (TLSs) for generation local antitumour immunity.We characterised functional states spatial organisation PDAC-infiltrating cells using single-cell RNA sequencing (scRNA-seq), flow cytometry, multicolour immunofluorescence, gene expression profiling microdissected TLSs, as well in vitro assays. In addition,...
Gastric cancer (GC) remains a formidable global health challenge, ranking among the top-five causes of cancer-related deaths worldwide. The majority patients face advanced stages at diagnosis, with mere 6% five-year survival rate. First-line treatment for metastatic GC typically involves fluoropyrimidine and platinum agent combination; yet, predictive molecular markers have proven elusive. This review navigates evolving landscape biomarkers, specific focus on Claudin 18.2 (CLDN18.2) as an...
Abstract Background Postoperative complications after gastric cancer resection vary in different series and they might have a significant impact long‐term outcomes. Our aim was to build prediction rule on patients' overall major morbidity risks. Methods This retrospective study included 1223 patients from single center who were resected between 1992 2016. Overall predictors identified through multiple logistic regression. Models' performances assessed discrimination, calibration,...
Abstract Background Gastric adenocarcinoma (GAC) is the third deadliest malignant neoplasm worldwide, mostly because of late disease diagnosis, low chemotherapy response rates, and an overall lack tumor biology understanding. Therefore, tools for prognosis prediction treatment are needed. Quantification circulating cells (CTCs) microemboli (CTM) their expression biomarkers has potential clinical relevance. Our aim was to evaluate CTCs CTM HER2 plakoglobin in patients with nonmetastatic GAC,...
Incidental gallbladder cancer is defined as a discovered by histological examination after cholecystectomy. It potentially curable disease. However, some questions related to their management remain controversial and strategy associated with better prognosis.To develop the first evidence-based consensus for of patients incidental in Brazil.Sixteen were selected, 36 Brazilian International members included answer them. The statements based on current evident literature. final report was sent...
There are no randomized data to guide treatment decisions for patients with advanced pancreatic adenocarcinoma following first-line FOLFIRINOX. We performed a systematic review and meta-analysis of studies using gemcitabine-based chemotherapy after FOLFIRINOX assess efficacy toxicity.We included published between 2011 2018 that evaluated the toxicity in adenocarcinoma. searched PubMed, Embase, Scopus, Web Science. Primary outcomes were objective response rate (ORR), disease control (DCR),...
369 Background: Gastric (GC) and pancreatic cancer (PC) have poor prognosis representing major public health challenges, particularly in Latin America. Real-world data are limited. GASPAR (LACOG 0222) study addresses this gap by creating a multicenter database to analyze epidemiological, clinical, pathological data, treatments, outcomes for patients (pts) with GC PC. Methods: This retrospective prospective observational cohort enrolled pts from 7 research sites 3 LATAM countries...
The development of targeted therapies has undoubtedly broadened therapeutic options for patients with colorectal cancer (CRC). use bevacizumab to reduce angiogenesis been associated improved clinical outcomes. However, an urgent need prognostic/predictive biomarkers anti-angiogenic still exists. Clinical data 105 CRC treated in conjunction chemotherapy were analyzed. expression vascular endothelial growth factor (VEGF) receptors, NOTCH1 receptor and its ligand DLL4 determined by...
FOLFIRINOX stands a major breakthrough in the management of metastatic pancreatic adenocarcinoma (MPA). Nonetheless, significant side-effects have been reported using standard FOLFIRINOX. We aimed to compare survival outcomes, response rates and toxicity patients treated with or modified MPA.We included aged ≥18 years old, pathologically confirmed MPA, first-line setting. Patients submitted at least one cycle full-dose were grouped group.Patients younger had less comorbidity. observed no...
Recent studies have suggested that sidedness of origin from colorectal adenocarcinomas is a predictor survival, however the impact this factor in patients with resected colon cancer liver metastases (CLM) not clear. So, study, we compared clinic and pathologic characteristics long-term survival CLM according to primary tumor location.This retrospective analyzes prospective database. Patients 1998 2012 were included. Right included tumors cecum middle transverse colon, left splenic flexure...
Hyperthermic intraperitoneal chemotherapy (HIPEC) has been associated with improved survival when compared surgery alone for non-metastatic gastric cancer patients in randomized trials and meta-analyses. However, little evidence is available regarding the use of HIPEC nonmetastatic who are treated perioperative radical surgery. The aim this study was to investigate putative benefit subgroup surgery.This a retrospective cohort that included gastroesophageal junction were curative resection...
Neuroendocrine neoplasms (NENs) are a rare group of cancers with heterogeneous behaviour and mostly unknown aetiology. Excluding some infrequent hereditary cancer syndromes, the extent clinical significance mutations in other predisposing genes (CPGs) not known. We aimed to investigate frequency pathogenic likely germline variants (GPVs) known CPGs young adults NEN molecular characteristics these patients. recruited 108 patients lung or digestive diagnosed between 18 50 years performed...
The association of preoperative systemic and intraperitoneal chemotherapy has been described in Eastern patients with very good outcomes treatment responders. aim this paper is to describe the initial results multidisciplinary regimen gastric cancer advanced peritoneal metastases. We present here first four cases who received protocol. They had a baseline PCI between 19 33. Two prior regimen. Three them significant response were taken cytoreductive surgery, while one patient 12 cycles...
The standard treatment for localized squamous-cell carcinoma of the anal canal is definitive chemoradiotherapy. A meta-analysis published studies conducted by our group showed significantly lower rates disease-free survival (DFS) and overall at 3 years among HIV-positive patients. We aimed to compare detailed outcomes between groups -negative patients.We performed a retrospective multicenter study comparative cohort consecutive patients with histologic diagnosis who received Patients'...