A5010169194- Sarcoma Diagnosis and Treatment
- Management of metastatic bone disease
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Knee injuries and reconstruction techniques
- Cardiac tumors and thrombi
- Medical Malpractice and Liability Issues
- Tumors and Oncological Cases
- Health Systems, Economic Evaluations, Quality of Life
- Virus-based gene therapy research
- Cervical Cancer and HPV Research
- Bone Tumor Diagnosis and Treatments
- Lymphoma Diagnosis and Treatment
- Ethics in Clinical Research
Leiden University Medical Center
2023-2025
Orthopedic One
2022
Risk prediction models (RPMs) are statistical tools that predict outcomes on the basis of clinical characteristics and can thereby support (shared) decision-making. With shift toward personalized medicine, number RPMs has increased exponentially, including in multimodal sarcoma care. However, their integration into routine soft-tissue (STS) care remains largely unknown. Therefore, we inventoried RPM use during tumor board discussions patient consultations as well attitudes to decision-making...
Myxofibrosarcoma and undifferentiated soft tissue sarcoma (USTS) are genetically complex sarcomas with distinct morphological features. Treatment typically involves surgery, often combined neoadjuvant chemo- or radiotherapy. To better understand the immunobiology of these its associations treatment response prognosis, we performed transcriptomic immunophenotypic profiling. RNA sequencing was on 13 USTS 10 myxofibrosarcomas immunological profiles were compared data from The Cancer Genome...
Bone and soft-tissue tumor patients experience long-lasting physical psychological challenges. It is unknown to what extent Health-Related Quality of Life (HRQoL) already affected during the diagnostic process. This study assesses HRQoL bone around time diagnosis explores which patient or characteristics are associated with a reduced HRQoL.All suspected benign/malignant (BT), benign (STT), malignant sarcoma (STS) visiting Leiden University Medical Center between 2016 2020 were invited...
Introduction: Changes in health-related quality of life (HRQoL) during the diagnostic and treatment trajectory high-grade extremity soft-tissue sarcoma (eSTS) has rarely been investigated for adults (18–65 y) elderly (aged ≥65 y), despite a potential variation challenges from diverse levels physical, social, or work-related activities. This study assesses HRQoL time diagnosis to one year thereafter among with eSTS. Methods: participants VALUE-PERSARC trial (n = 97) was assessed at 3, 6 12...
Introduction Current treatment decision-making in high-grade soft-tissue sarcoma (STS) care is not informed by individualised risks for different options and patients’ preferences. Risk prediction tools may provide patients professionals insight personalised benefits thereby potentially increase knowledge reduce decisional conflict. The VALUE-PERSARC study aims to assess the (cost-)effectiveness of a risk assessment tool (PERSARC) about conflict comparison with usual extremity STS patients....
Introduction Current literature is inconclusive about the optimal treatment of elderly patients with displaced intra-articular distal radius fractures. Cast less invasive and expensive than surgical treatment. Nevertheless, surgery often preferred for this common type fracture. Patients a non-acceptable position after closed reduction are more likely to benefit from an acceptable reduction. Therefore, study aims assess non-inferiority functional outcomes casting versus in following Methods...
Follow-up (FU) in soft-tissue sarcoma (STS) patients is designed for early detection of disease recurrence. Current guidelines are not evidenced-based and tailored to patient or tumor characteristics, so they remain debated, particularly given concerns about cost, radiation frequency, over-testing. This study assesses the extent which STS received guideline-concordant FU characterize type more fewer visits than advised. All surgically treated at Leiden University Medical Center between...