A5062636371- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Immune cells in cancer
- Lipid Membrane Structure and Behavior
- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Dementia and Cognitive Impairment Research
- Sleep and Wakefulness Research
- Neurological Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
Amsterdam Neuroscience
2020-2024
Vrije Universiteit Amsterdam
2020-2024
University of California, Los Angeles
2022
VIB-KU Leuven Center for Brain & Disease Research
2017
KU Leuven
2017
As cancer is becoming more and a chronic disease, large proportion of patients confronted with devastating side effects certain anti-cancer drugs. The most common neurological complications are painful peripheral neuropathies. Chemotherapeutics that interfere microtubules, including plant-derived vinca-alkaloids such as vincristine, can cause these chemotherapy-induced neuropathies (CIPN). Available treatments focus on symptom alleviation pain reduction rather than prevention the neuropathy....
Within eukaryotic cells, translation is regulated independent of transcription, enabling nuanced, localized, and rapid responses to stimuli. Neurons respond transcriptionally translationally synaptic activity. Although transcriptional are documented in astrocytes, here we test whether astrocytes have programmed translational responses. We show that seizure activity rapidly changes the transcripts on astrocyte ribosomes, some predicted be downstream BDNF signaling. In acute slices, quantify...
Astrocyte-synapse bi-directional communication is required for neuronal development and synaptic plasticity. Astrocytes structurally interact with synapses using their distal processes also known as leaflets or perisynaptic astrocytic (PAPs). We recently showed that these PAPs are retracted from hippocampal synapses, involved in the consolidation of fear memory. However, whether coverage affected when memory impaired unknown.Here, we describe detail an electron microscopy method makes use a...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, the neuropathological formation of amyloid-beta (Aβ) plaques and neurofibrillary tangles. The best cellular correlates early deficits in AD patients are synapse loss gliosis. In particular, it unclear whether activation microglia (microgliosis) has neuroprotective or pathological role AD. Here we report that microgliosis an mediator synaptic dysfunction impairment APP/PS1 mice, mouse model increased...
Loss of function the astrocyte membrane protein MLC1 is primary genetic cause rare white matter disease Megalencephalic Leukoencephalopathy with subcortical Cysts (MLC), which characterized by disrupted brain ion and water homeostasis. prominently present around fluid barriers in brain, such as endfeet contacting blood vessels processes meninges. Whether plays a role other domains unknown. Here, we show that distal processes, also known perisynaptic (PAPs) or leaflets, closely interact...
Abstract INTRODUCTION Early‐life stress (ES) increases the risk for Alzheimer's disease (AD). We and others have shown that ES aggravates amyloid‐beta (Aβ) pathology promotes cognitive dysfunction in APP/PS1 mice, but underlying mechanisms remain unclear. METHODS studied how affects hippocampal synaptic proteome wild‐type (WT) mice at early late pathological stages, validated hits using electron microscopy immunofluorescence. RESULTS The synaptosomes of both ES‐exposed WT early‐stage showed...
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative and the most common cause of dementia, characterized by deposition extracellular amyloid‐beta (Aβ) aggregates intraneuronal hyperphosphorylated Tau. Many AD risk genes, identified in genome‐wide association studies (GWAS), are expressed microglia, innate immune cells central nervous system. Specific subtypes microglia emerged relation to pathology, such as disease‐associated (DAMs), which increased number with age amyloid...
Abstract Gene expression requires two steps – transcription and translation which can be regulated independently to allow nuanced, localized, rapid responses cellular stimuli. Neurons are known respond transcriptionally translationally bursts of brain activity, a transcriptional response this activation has also been recently characterized in astrocytes. However, the extent astrocytes is unknown. We tested hypothesis that have programmed translational by characterizing change transcript...
Summary Astrocyte distal processes, known as leaflets or perisynaptic astrocyte processes (PAPs), fine-tune synaptic activity by clearing neurotransmitters and limiting extrasynaptic glutamate diffusion. While learning memory depends on orchestrated of neuronal ensembles within the hippocampus, it is becoming increasingly evident that astrocytes residing in environment these synapses play a central role shaping memories. However, how astroglial coverage contributes to mnemonic processing...
Abstract Epidemiological evidence indicates that early life stress (ES) exposure increases the risk for later-life diseases, such as Alzheimer’s disease (AD). Accordingly, we and others have shown ES aggravates development of, response to, amyloid-beta (Aβ) pathology in animal models. Moreover, ES-exposed transgenic APP/PS1 mice display deficits both cognitive flexibility synaptic function. As mechanisms behind these changes were unclear, here investigated how to ES, using limited nesting...