A5013655546- Phytase and its Applications
- Hemoglobinopathies and Related Disorders
- Protein Hydrolysis and Bioactive Peptides
- Food and Agricultural Sciences
- Epigenetics and DNA Methylation
- Prenatal Screening and Diagnostics
- Enzyme Production and Characterization
- Probiotics and Fermented Foods
- Plant Micronutrient Interactions and Effects
- Diverse Scientific Research Studies
- Iron Metabolism and Disorders
- Blood groups and transfusion
Muhimbili University of Health and Allied Sciences
2023-2024
Tohoku University
2023-2024
Sebelas Maret University
2018-2022
The clinical severity of sickle cell disease (SCD) is strongly influenced by the level fetal haemoglobin (HbF) persistent in each patient. Three major HbF loci (BCL11A, HBS1L-MYB, and Xmn1-HBG2) have been reported, but a considerable hidden heritability remains. We conducted genome-wide association study for levels 1006 Nigerian patients with SCD (HbSS/HbSβ0), followed replication meta-analysis exercise four independent cohorts (3,582 patients). To dissect signals at loci, we performed...
Human genetic variation has enabled the identification of several key regulators fetal-to-adult hemoglobin switching, including BCL11A, resulting in therapeutic advances. However, despite progress made, limited further insights have been obtained to provide a fuller accounting how contributes global mechanisms fetal (HbF) gene regulation. Here, we conducted multi-ancestry genome-wide association study 28,279 individuals from cohorts spanning 5 continents define architecture human impacting...
Aspergillus niger is a filamentous fungus which has been used in industries for the production of metabolites and enzymes like phytase. The present study aimed at performing phylogenetic analysis A. isolates from soybean Sorghum flour based on ITS region. Genomic DNA phytase positive fungal was isolated set primers ITS1F ITS4R were to amplify region sequenced. Similarity search performed National Center Biotechnology Information (NCBI) comparison with reference sequences identification....
Abstract Background The clinical severity of sickle cell disease (SCD) is strongly influenced by the level fetal haemoglobin (HbF) persistent in each patient. Three major HbF loci ( BCL11A , HBS1L-MYB and Xmn1-HBG2 ) have been reported, but a considerable hidden heritability remains. Aim Building on power large genetically diverse patient pool present Nigeria, we conducted genome-wide association study for levels patients from three regions country with ethnic make-up. Methods We analysed...
Karakterisasi Biokimia Enzim Fitase Rekombinan (phyK) dari Klebsiella sp. ASR1 Yang Dienkapsulasi Dengan AlginatEnzim fitase melepas molekul fosfor pada atom C benzena Inositol fitat. Tetapi memiliki kelemahan tidak mampu bertahan terhadap kondisi ekstrim dalam lambung nonruminansia. Solusi penelitian ini yaitu dienkapsulasi menggunakan alginat. Penelitian bertujuan mengkarakterisasi setelah alginate. Hasil yang aktivitas tertinggi pH 6,0, sedangkan tanpa enkapsulasi 5,0. Suhu optimum untuk...
This research aimed at analyzing the phytase from fungal isolates SB1, SB2, BS, and WF produced in cornstarch with glucose medium (CS+Glu) as carbon sources Potatoes dextrose broth (PDB). The activity of CS+Glu was 2.97 UmL-1, 2.87 3.18 4.37 respectively, while phytases 2.07 2.17 2.22 2.78 UmL-1 respectively PDB medium. optimal temperature SB1 40°C, SB2 BS were 50°C 60°C, respectively. pH 5.0, 6.0, 4.0 18S rRNA gene analysis revealed that 99% identical to Aspergillus niger ANTS (KY825168.1),...
Since the onset of COVID-19 in early 2020, various approaches have been adopted worldwide by state health authorities containing ravaging pandemic. Tanzania additional approach based on Tanzanian Traditional Medicines. This review aimed to explore suitability this local evaluation virus biology, pathogenesis and immunology relation traditional medicines, nutritional immunology, steaming practice contents medicinal plants potential impact their combinations. Data related COVID-19, dietary...