A5069128842- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Hippo pathway signaling and YAP/TAZ
- Cell Adhesion Molecules Research
- Protein Kinase Regulation and GTPase Signaling
Universidade de Santiago de Compostela
2020-2022
Center for Research in Molecular Medicine and Chronic Diseases
2020-2022
Background: Cavernous cerebral malformations can arise because of mutations in the CCM1 , CCM2 or CCM3 genes, and lack Cdc42 has also been reported to induce these mice. However, role (cerebral cavernous malformation 3)-associated kinases cavernoma development is not known, we, therefore, have investigated their process. Methods: We used a combination an vivo approach, using mice genetically modified be deficient CCM3-associated STK24 STK25 (serine/threonine 24 25), vitro model human...
Cerebral cavernous malformations (CCMs) are vascular that can be the result of deficiency one CCM genes. Their only present treatment is surgical removal, which not always possible, and an alternative pharmacological strategy to eliminate them actively sought. We have studied effect lack genes, CCM3, in endothelial non-endothelial cells. By comparing protein expression control CCM3-silenced cells, we found levels Epidermal Growth Factor Receptor (EGFR) higher CCM3-deficient adds known...