A5069531413- Pain Mechanisms and Treatments
- Meta-analysis and systematic reviews
- Anesthesia and Pain Management
- Botulinum Toxin and Related Neurological Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Delphi Technique in Research
- Reliability and Agreement in Measurement
- Myofascial pain diagnosis and treatment
- Adipose Tissue and Metabolism
- Pediatric Pain Management Techniques
- Statistical Methods in Clinical Trials
- MRI in cancer diagnosis
- Pancreatic function and diabetes
- Cancer Treatment and Pharmacology
- Pain Management and Treatment
- Wikis in Education and Collaboration
- Musculoskeletal pain and rehabilitation
- Childhood Cancer Survivors' Quality of Life
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Ion Channels and Receptors
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Advancements in Transdermal Drug Delivery
- Colorectal and Anal Carcinomas
University of Split
2014-2024
Klinički Bolnički Centar Rijeka
2024
Urology Team
2017
Assessing the risk of bias (RoB) in included studies is one key methodological aspects systematic reviews. Cochrane reviews appraise RoB randomised controlled trials (RCTs) with tool. Detailed instructions for using tool are provided Handbook Systematic Reviews Interventions (The Handbook). The purpose this study was to analyse whether authors use adequate judgments about random sequence generation RCTs reviews.We extracted authors' (high, low or unclear RoB) and supports (comments...
Aim: To analyze awareness about and acceptability of core outcome set (COS) for pediatric pain recommended by the PedIMMPACT. Methods: We invited authors systematic reviews randomized controlled trials interventions postoperative in children to participate a survey. Results: Only third surveyed had heard PedIMMPACT COS acute pain. Problems indicated as preventing them from using were lack awareness, difficulties with implementation, resources. Conclusion: Further discussions adequacy pain,...
The degree of pain caused by the implantation cardiac electronic devices (CEDs) and type anesthesia or perioperative management used with procedure have been insufficiently studied. aim this study was to analyze management, as well intensity location among patients undergoing CED, compare practice published guidelines.This a combined retrospective prospective conducted at tertiary hospital, University Hospital Split, Croatia. sample included 372 who underwent CED implantation. Perioperative...
Introduction: Magnet ingestion usually does not cause serious complications, but in case of multiple magnet or with other metal it could intestinal obstruction, fistula formation even perforation. Case report: We report obstruction and following 25 magnets a 2-year-old girl. Intraoperatively omega shaped loop caused by two magnetic balls was found. Intestine trapped edematous inflamed. Resection segment performed, followed entero-enteric anastomosis. A total were removed from resected...
Aim: Adequate judging of risk bias (RoB) for blinding outcome assessors (detection bias) is important supporting highest level evidence. Materials & methods: Judgments and comments detection were retrieved from RoB tables reported in Cochrane reviews. We categorized comments, then compared judgment comment with instructions the Handbook. Results: analyzed 8656 judgments 7626 trials included 575 Overall, 1909 (22%) not line In 9% trials, authors split domain according to outcomes. Here,...
Abstract Background Bias in randomized controlled trials (RCTs) can lead to underestimation or overestimation of the true effects interventions. Surgical RCTs may suffer from risk bias (RoB) that is avoidable other interventions, and vice versa. We aimed compare adequacy RoB assessments surgical versus non-surgical included Cochrane reviews assess most common differences those assessments. Due specificities trials, i.e. difficulties associated with blinding we hypothesized be more adequate,...
Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered one of the key intracellular signaling proteins for development neuropathy. We analyzed expression total CaMKII (tCaMKII) and its alpha, beta, gamma delta isoforms in dorsal root ganglia (DRG) a rat model Diabetes mellitus type I (DM1), 6 months 1 year after diabetes induction. was induced with streptozotocin confirmed by measuring glucose levels weight increase. Immunohistochemistry performed detection tCaMKII L4 L5 DRGs....
The aim of this study was to investigate the expression total calcium/calmodulin-dependent protein kinase II (CaMKII) and its phosphorylated α isoform in dorsal horn spinal cord an animal model long-term diabetes. Diabetes induced Sprague-Dawley rats using 55 mg/kg streptozotocin, CaMKII, α-CaMKII isoform, isolectin B4 analyzed by immunohistochemical analysis 6 12 months after diabetes induction. Results were compared with those for control same age. Increased CaMKII activated seen diabetic...
Inadequate treatment of pain related to surgery may be associated with complications and prolonged recovery time increased morbidity mortality rates. We investigated perioperative management in vascular compared it the relevant guidelines for pain.We conducted a retrospective study on 501 patients who underwent at University Hospital Split, Croatia. collected following data from patients' charts: age, gender, premedication, preoperative patient's physical status, type surgery, duration...
Abstract Background Purpose of this study was to analyze adequacy judgments about risk bias (RoB) for random sequence generation in Cochrane systematic reviews (CSRs) randomized controlled trials (RCTs). Methods Information extracted from RoB tables CSRs using automated data scraping. We categorized all comments provided as supports related randomization. analyzed number and type various supporting assessed judgment randomization line with recommendations the Handbook. Results 10527 RCTs...
The potential benefit of neoadjuvant chemotherapy (NAC) in colon cancer is under evaluation. There a need to improve preoperative non-invasive diagnostics using techniques that provide more accurate staging information assessing patient eligibility for NAC.To investigate the link between tumor grade (pathohistological confirmed) and N status (corresponding lymph node involvement) with apparent diffusion coefficient (ADC) values.A total 17 patients planned surgical resection had biopsy...
Abstract Background Initially, the Cochrane risk of bias (RoB) tool had a domain for “blinding participants, personnel and outcome assessors”. In 2011 tool, assessment blinding was split into two domains: participants (performance bias) assessors (detection bias). The aims this study were twofold; first, to analyze frequency usage joint (a single performance detection bias), second, assess proportion adequate assessments made in versus RoB domains by comparing whether authors’ judgments...
Benigne bolesti anorektalne regije,