A5015398654- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Estrogen and related hormone effects
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Cancer, Lipids, and Metabolism
- Additive Manufacturing and 3D Printing Technologies
- Prosthetics and Rehabilitation Robotics
- Cancer, Stress, Anesthesia, and Immune Response
- Orthopedic Surgery and Rehabilitation
- Bone Tissue Engineering Materials
- Intraperitoneal and Appendiceal Malignancies
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Ethics and bioethics in healthcare
- Medical research and treatments
- Biomedical Research and Pathophysiology
- Parasitic Diseases Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Parathyroid Disorders and Treatments
- Law, Economics, and Judicial Systems
- Vascular anomalies and interventions
- Structural Integrity and Reliability Analysis
- Urologic and reproductive health conditions
- Multiple and Secondary Primary Cancers
Pontifical Catholic University of Peru
2025
Universidad de León
2020
Janssen (United States)
2015
Menlo School
2015
Dana-Farber Cancer Institute
2009
Institute of Cancer Research
2009
Beth Israel Deaconess Medical Center
2009
Sidney Kimmel Comprehensive Cancer Center
2009
Memorial Sloan Kettering Cancer Center
2009
This work aims to study the influences of nozzle temperature, layer thickness and raster angles on mechanical properties acrylonitrile butadiene styrene (ABS) polylactic acid (PLA) specimens fabricated by material extrusion 3D printing. Tensile tests were carried out in order evaluate ABS PLA specimens. The results showed that tensile strength decreased at a higher temperature for ABS, while an increase followed decrease occurred PLA, with maximum value obtained 250 °C. Scanning electronic...
De Quervain's tenosynovitis is a pathology that affects the tendons of thumb and generates pain inflammation, being common in people between 18 30 years old who perform repetitive movements. Despite innovation 3D printing orthotics, customization lacking. Therefore, this works aims to develop printed customized wrist-hand orthosis (WHO) for treatment Quervain tenosynovitis. The WHO includes three main parts, which would be two faces cover front back hand locks ensure coupling both faces....
In this study, reinforced thermoplastic nanoclay particle composites were prepared and used as filaments for additive manufacturing of specimens by using fused filament fabrication (FFF). Acrylonitrile butadiene styrene (ABS) polylactic acid (PLA) polymer matrices. The composite feedstock fabricated from ABS PLA pellets with different contents particles in a twin-screw extruder. Tensile impact tests carried out to evaluate the mechanical properties FFF. test results showed an increase...
5048 Background: AA is a potent blocker of CYP17, required for synthesis testosterone in the testes, adrenals, and prostate tissue. Study objectives included confirming antitumor activity safety multicenter setting, describing changes ECOG PS, comparing keto-naïve pts to keto-exposed pts. Methods: The 58 had progressive, metastatic CRPC failed hormonal therapy up two cytotoxic regimens, including docetaxel. (1,000 mg QD) prednisone (5mg BID) were administered daily, registration trial...
4545 Background: The utility of bone scintigraphy in metastatic prostate cancer is limited by the risk false positive findings. False positives can occur for many reasons, including a “flare” phenomenon due to osteoblastic response that occurs as result healing after successful anti-neoplastic therapy. incidence flare unknown clinically but important because it patients (pts) being taken off active agents too soon on basis potentially erroneous scans. Methods: 33 pts with progressive...
4500 Background: AA and ketoconazole (keto) both inhibit CYP 17, the rate limiting enzyme in androgen synthesis. Since mechanisms of resistance to these agents may be overlapping, patients (pts) with prior keto exposure were excluded from randomized phase III trials. In current study mCRPC who have received therapy treated AA. Methods: Eligibility required progressive for >28 days. Prior chemotherapy was not allowed. Pts normal baseline organ function ACTH stimulation test. Therapy consisted...
5017 Background: Responses to the CYP 17 inhibitor, AA, confirm therapeutic significance of persistent androgen signaling in CRPC. Elucidating source residual androgens and validation predictive markers will lead individualized deprivation therapy Methods: We performed an exploratory study screen for associations between serum (endocrine) microenvironment (paracrine) concentration response AA. Study pts had bone metastases a BM biopsy. Pts received oral AA 1,000mg QD prednisone 10mg have...
4547 Background: To detemine effects of AA plus prednisone in CRPC bone and their association to patient (pt) tumor characteristics. Methods: Study pts had progressive with <50 ng/dl serum testosterone (S-T), metastases agreed serial marrow biopsy. Pts received oral 1,000 mg QD 5 BID. Results: Between 10/07 4/09, 56 median age 70 yrs (range 48-87), PS-ECOG 2 0-2) baseline PSA concentration 95.3 3-2,725), enrolled. Thirty-six (64%) DES and/or ketoconazole, 47 (84%) prior chemotherapy [≥2...