A5053116754- Lignin and Wood Chemistry
- Surfactants and Colloidal Systems
- Advanced biosensing and bioanalysis techniques
- Polymer crystallization and properties
- Natural Fiber Reinforced Composites
- Phase Equilibria and Thermodynamics
- Chemical Synthesis and Analysis
- Polymer Nanocomposites and Properties
- Estrogen and related hormone effects
- Food Drying and Modeling
- Microencapsulation and Drying Processes
- Structural Analysis of Composite Materials
- RNA Interference and Gene Delivery
- Freezing and Crystallization Processes
- Metabolomics and Mass Spectrometry Studies
- Food Chemistry and Fat Analysis
- Aerogels and thermal insulation
- Nanopore and Nanochannel Transport Studies
- Analytical Chemistry and Chromatography
- Essential Oils and Antimicrobial Activity
- Biofuel production and bioconversion
- Advanced Photocatalysis Techniques
- Retinoids in leukemia and cellular processes
- Supercapacitor Materials and Fabrication
- Quinazolinone synthesis and applications
University of Kentucky
2018-2022
Louisiana State University
2021
Aim: Few targeted therapies are available for triple-negative breast cancer (TNBC) patients. Here, we propose a novel alkaline-lignin-conjugated-poly(lactic-co-glycolic acid) (L-PLGA) nanoparticle drug delivery system to improve the efficacy of therapies. Materials & methods: L-PLGA nanoparticles (NPs) loaded with MEK1/2 inhibitor GDC-0623 were characterized, tested in vitro on MDA-MB-231 TNBC cell line and compared PLGA NPs. Results: Loaded NPs less than half size NPs, had slower release...
High resolution differential scanning calorimetry (DSC) and molecular dynamics (MD) simulations were used to investigate the effect of three lignin dimers on gel fluid phase transition in DPPC lipid bilayers. The goal this research is begin understand partitioning model into bilayers its effects temperature (Tm). long-term objective establish structure–function relationships for well-defined derivatives at biologically relevant surfaces. This work uses a newly synthesized guiacylglycerol...
Amine-functionalized mesoporous silica nanoparticles (MSNPAs) are ideal carriers for oligonucleotides gene delivery and RNA interference. This investigation examines the thermodynamic driving force of interactions double-stranded (ds) with MSNPAs as a function length (84 282 base pair) particle pore diameter (nonporous, 2.7, 4.3, 8.1 nm) using isothermal titration calorimetry, extending knowledge solution-based nucleic acid–polycation to confined in nanopores. Adsorption follows two-step...
Abstract The drying behavior of different freshwater fishes (with/without scales) is investigated using a simple convective heated air dryer. Drying processes are analyzed to study the kinetics drying, shrinkage dependent variable effective diffusivity, heat and mass transport, energy aspect drying. Among kinetic models, Hasibuan–Daud Haghi–Angiz‐I models produce best fit for with scales Hii model produces fish without scales. Diffusion analysis performed based on simplified solution Fick's...
Successful strategies for the attachment of oligopeptides to mesoporous silica with pores large enough load biomolecules should utilize high surface area provide an accessible, protective environment. A two-step oligopeptide functionalization strategy is examined here using diazirine-based heterobifunctional linkers. Mesoporous nanoparticles (MSNPs) average pore diameter ~8 nm and ~730 m2/g were synthesized amine-functionalized. Tetrapeptides Gly-Gly-Gly-Gly (GGGG) Arg-Ser-Ser-Val (RSSV), a...
ABSTRACT The environmental issues associated with the mass discarding of waste plastics in Philippines have significantly raised for past decade. However, this country is a home to many natural fibers which necessitates development ecofriendly materials diminish footprint polymers. High‐density polyethylene (HDPE) was filled floured untreated and 5 wt % alkaline‐treated Salago fiber via melt compounding. physical mechanical characteristics both types composites were measured compared....
A study of the interaction between cell membranes and small molecules derived from lignin, a protective phenolic biopolymer found in vascular plants, is crucial for identifying their potential as pharmacological toxicological agents. In this work, interactions model [supported 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid bilayers] are compared three βO4 dimers coniferyl alcohol (G lignin monomer): guaiacylglycerol guaiacol ester with hydroxypropenyl (HOC3H4-) tail (G-βO4'-G),...
ABSTRACT Fillers are utilized for different purposes. In plastic industry, fillers mainly used to extend the bulk of compound; however, they can also improve physical properties, materials processing, and reduce cycle time plastics. this article, high‐density polyethylene was filled with untreated 5% alkaline‐treated salago fiber, thereafter thermal nondestructive properties composites were investigated. It found that chemical treatment fiber increased stability mean coefficient value linear...
Lignin derived from lignocellulosic biomass is the largest source of renewable bioaromatics present on earth and requires environmentally sustainable separation strategies to selectively obtain high-value degradation products. Applications supramolecular interactions have potential isolate lignin compounds fractions by formation variable inclusion complexes with cyclodextrins (CDs). CDs are commonly used as selective adsorbents for many applications can capture guest molecules in their...
Abstract In 2019, it is predicted that more than a quarter of million women in the U.S. will be diagnosed with breast cancer (BC). Nearly 15% those cases classified as triple negative (TNBC). Patients TNBC typically have worse prognosis due to its lack classically targeted hormone receptors associated other BC subtypes. Because well tolerated endocrine therapies cannot used treat TNBC, novel and drug delivery systems must created. They are needed assist physicians battling while minimizing...