A5029891322- Pelvic floor disorders treatments
- Surgical site infection prevention
- Surgical Sutures and Adhesives
- Orthopedic Infections and Treatments
- Urinary Tract Infections Management
- Mesenchymal stem cell research
- Sports injuries and prevention
- Proteoglycans and glycosaminoglycans research
- Pregnancy-related medical research
- Anorectal Disease Treatments and Outcomes
- Osteoarthritis Treatment and Mechanisms
- Pressure Ulcer Prevention and Management
- Protease and Inhibitor Mechanisms
- Health and Wellbeing Research
- Musculoskeletal pain and rehabilitation
- Cell Adhesion Molecules Research
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- Pelvic and Acetabular Injuries
- Cancer Cells and Metastasis
- Reconstructive Surgery and Microvascular Techniques
- Sports Performance and Training
- Motivation and Self-Concept in Sports
- Platelet Disorders and Treatments
- Clinical practice guidelines implementation
Smith & Nephew (United Kingdom)
2019-2023
Swansea Bay University Health Board
2016-2023
Singleton Hospital
2019-2021
Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust
2015-2018
Robert Jones and Agnes Hunt Orthopaedic Hospital
2011-2016
Keele University
2011
Wound complications are reported in up to 10% hip and knee arthroplasties there is a proven association between wound deep prosthetic infections. In this randomised controlled trial (RCT) we explore the potential benefits of portable, single use, incisional negative pressure therapy dressing (iNPWTd) on exudate, length stay (LOS), complications, changes cost-effectiveness following total arthroplasties.A 220 patients undergoing elective primary were recruited into non-blinded RCT. For final...
Mesenchymal stem cells (MSCs) can be mobilized from the bone marrow and enter circulation. Conversely, MSCs recruited circulation into marrow. For these migratory pathways, have to traverse endothelium, in a basal-to-apical apical-to-basal direction, respectively. Here we describe cues that drive MSC transendothelial migration both directions with focus on chemokines. Live cell imaging electron microscopy were used examine interaction of human endothelial (HBMECs), transmigration analyzed....
Abstract Endothelial surface microstructures have been described previously under inflammatory conditions; however, they remain ill-characterized. In this study, CXCL8, an chemokine, was shown to induce the formation of filopodia-like protrusions on endothelial cells; same effects were observed with CXCL10 and CCL5. Chemokines stimulated filopodia by both microvascular (from bone marrow skin) macrovascular human umbilical vein) cells. Use blocking Abs degradative enzymes demonstrated that...
ObjectivesPsychological comorbidities are associated with non-attendance for pelvic-floor muscle training (PFMT) appointments and non-engagement ongoing treatment. However, little direct work has examined the precise relationship between these variables.DesignA prospective observational study of consecutively referred women patients Pelvic-floor Dysfunction. Patients were assessed at intake age, BMI, pelvic symptoms (measured by Queensland Pelvic Symptom Scale), anxiety depression Hospital...
Pelvic floor muscle training (PFMT) is effective, acceptable to patients, and cost efficient as a treatment for Floor Dysfunction (PFD). However, PFMT outcomes are mediated by patient variables, such depression, anxiety, motivation, health values. The current study examined whether multi-disciplinary provision of involving psychologist would improve attendance (Clinical Trial Registration: NCT02549157). 88 consecutively referred patients (age 28 − 85 years), with variety PFD, were randomised...
Surgical site complications (SSCs), including surgical infection (SSI), are common following C-sections. Management of the post-operative incision with single-use negative pressure wound therapy (sNPWT) has been shown to reduce risk SSC in high-risk individuals. This study explored outcomes routine, real-world use sNPWT patients undergoing An observational, retrospective in-service evaluation was conducted across eight obstetric centres Republic and Northern Ireland. Patients C-sections were...
This study explores the reasons for patient non-attendance at scheduled pelvic floor muscle training (PFMT) sessions. Although only limited research has been conducted on this topic, it is crucial to understand its implications resources, rates and significance of underlying reasons. Forty-four women were selected random from patients with dysfunction who had not attended a PFMT session within past 12 months. Semi-structured telephone interviews used gain information about non-attendance,...
Background: The current study examined how temperature affects attendance at psychological tele-support sessions for women undergoing treatment pelvic-floor muscle (PFM) related symptoms. It compared this relationship between when the appointments were publicly-funded or privately offered without cost to patient. This is first compare both and privately-offered free.
The current paper provides an overview of treatment noncompliance at various points in the pathway, especially with respect to for Pelvic-floor Dysfunction (PFD). effects on healthcare are considered, and examples supporting patients psychologically increase compliance discussed. An outline a method identify costs non-compliance, where such most intensely impact system, is provided. It suggested that psychological support effective terms increased improved economics. model presented PFD, but...