A5061890110- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- RNA modifications and cancer
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Multiple Sclerosis Research Studies
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Inflammasome and immune disorders
- Adenosine and Purinergic Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
Tabriz University of Medical Sciences
2020-2025
Imam Reza Hospital
2021
Hawler Medical University
2021
Introduction Cancer immunotherapy is more dependent on monoclonal antibodies, proteins, and cells, as therapeutic agents, to attain prominent outcomes. However, cancer immunotherapy's clinical benefits need be enhanced, many patients still do not respond well existing treatments, or their diseases may relapse after temporary control. RNA-based approaches have provided new options for advancing immunotherapy. Moreover, considerable efforts been made utilize RNA vaccine production. vaccines,...
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory immune checkpoint that can be expressed in tumor-infiltrating lymphocytes and colorectal cancer (CRC) cells. This attenuate anti-tumoral responses facilitate tumor growth metastasis. Although capecitabine effective chemotherapeutic agent for treating CRC, its effect on the tumoral CTLA-4 expression remains unclear. In current research, we applied GSE110224 GSE25070 datasets to characterize CRC patients. Then, analyzed samples, HT-29,...
Background: The coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has been declared a global pandemic. It is well-established that SARS-CoV-2 infection can lead to dysregulated immune responses. Arginase-1 (Arg1), which pivotal role in cells, be expressed most of the myeloid e.g., neutrophils and macrophages. Arg1 associated with suppression antiviral Methods: Whole blood was taken from 21 COVID-19 patients healthy individuals, after...
Abstract Background Glioblastoma multiform (GBM) is among the commonly diagnosed brain malignancies with poor prognosis. CD133 has been introduced as an oncogene in various cancers, like GBM. This study aimed to investigate significance of GBM development using silico and vitro techniques. Method The TCGA-GBM database was analyzed for correlational comparative studies. After selecting U87MG cell line, CD133-siRNA transfected into cells treated temozolomide. viability, cycle, migration,...
Triple-negative breast cancer (TNBC) is an invasive tumor with a high incidence of distant metastasis and poor prognosis. In TNBC cells, PD-L1 expression can induce immunosuppressive microenvironment, repressing the anti-tumoral immune responses. Although FDA-approved agents targeting PD-1/PD-L1 axis are potent to eliminate tumoral their immune-related adverse events have become worrisome. As regulator gene expression, siRNAs directly target in cells. The modification reduce our reliance on...
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that characterized by inflammation which typically results in significant impairment most patients. Immune checkpoints act as co-stimulatory and co-inhibitory molecules play fundamental role keeping equilibrium immune system. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) Programmed death-ligand 1 (PD-L1), inhibitory checkpoints, participate terminating development numerous autoimmune diseases,...