A5023710366- Supramolecular Chemistry and Complexes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Porphyrin and Phthalocyanine Chemistry
- Molecular Sensors and Ion Detection
- Analytical Chemistry and Chromatography
- Asymmetric Hydrogenation and Catalysis
- Lipid Membrane Structure and Behavior
- Photoreceptor and optogenetics research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Crystallography and molecular interactions
- Hemoglobin structure and function
Radboud University Nijmegen
2018-2021
Nitration of tetraphenylporphyrin cage compound 1, at -40 °C, leads to the regioselective formation chiral mononitro 2 (75% isolated yield) and, -30 achiral syn-dinitro-derivative 3 and anti-dinitro derivative 4 in a diastereomeric ratio 5:2, which were separated by chromatography (46 20% yields, respectively). The structures compounds confirmed X-ray crystallography.
An improved and scalable synthetic route to chiral porphyrin cage compounds, which will be used as catalytic machines for the encoding of information into polymers, has been developed. The was made by introducing one or two nitro groups on its xylylene sidewalls. This nitration performed with fuming nitric acid at low temperature occurred in a highly regioselective fashion. latter thought result binding nitronium cation inside cavity compound, directing reaction However, 1H NMR titrations...
Abstract Continuous flow chemistry holds great potential for the production of biologically relevant molecules. Herein, we present an approach continuous synthesis cannabidiol and tetrahydrocannabinol in a one-flow system. The designed route consists reaction cascade involving Friedel-Crafts alkylation, subsequent ring opening cyclisation up to 45% yield. reactions were successfully performed using both hetero- homogeneous Lewis acids provide yields that are similar comparable batch...
As part of a project aimed at the development chiral processive catalysts that can write information on polymer chain we describe synthesis two optically active porphyrin macrocycles, which are prepared in 3 steps from an achiral precursor compound. Fluorescence and
We report the face-selective threading of a chiral porphyrin cage compound onto viologen guests that are provided on both ends with substituents different sizes. Depending types terminal groups guest orients itself in one two possible directions.