A5013069172- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Selenium in Biological Systems
- Acute Lymphoblastic Leukemia research
- Nigella sativa pharmacological applications
- Sesame and Sesamin Research
- Silymarin and Mushroom Poisoning
- Trace Elements in Health
- Medicinal Plants and Neuroprotection
- Pharmacological Effects of Natural Compounds
- Vitamin C and Antioxidants Research
- Heavy Metal Exposure and Toxicity
- Childhood Cancer Survivors' Quality of Life
- Potato Plant Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Nanoparticles: synthesis and applications
- Pregnancy and Medication Impact
- Safe Handling of Antineoplastic Drugs
- Natural Compound Pharmacology Studies
- Carcinogens and Genotoxicity Assessment
- Medical and Biological Ozone Research
- Curcumin's Biomedical Applications
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Aluminum toxicity and tolerance in plants and animals
Eskişehir Osmangazi University
2016-2025
Teknoloji Arastirma ve Gelistirme Endustriyel Urunler Bilisim Teknolojileri San Tic
2023
Sabancı Üniversitesi
2023
Eskişehir City Hospital
2019
To investigate the effects of escin (ES) on acute damage induced by alkylating agent, experimental rats were injected with cyclophosphamide (CPM) to cause liver damage. The animals divided into four groups: Control Group, CPM (200 mg/kg), ES (10 CPM, and Groups. Immunohistopathological, hepatic histopathological, biochemical changes analyzed. activities aspartate aminotransferase (AST), alanine (ALT), lactate dehydrogenase (LDH), malondyaldehyde (MDA), glutathion (GSH), total oxidant status...
Although female genital mutilation is widespread in Africa, it a worldwide fact that practiced by more than 200 million women many countries, especially the Middle and Far East. It performed different ways countries around world. Lifelong physiological, psychiatric, obstetric problems are inevitable due to loss of anatomical tissue area after mutilation. In this study, degree disability, problems, behavior, attitudes Somali living Turkey were investigated. For purpose, situation 190 15...
Abstract The purpose of this study is to measure the effects acrylamide (AA) on bone marrow and blood protective efficacy boric acid (B) in rats. animals were divided into five groups: control, B, low-dose B + AA, high-dose AA. After 15 th day experiment, their harvested be kept for hematological analyses. While white cells (WBC) increased following administration bodyweight, red cells, platelets, hemoglobin, hematocrit, nucleated cell counts significantly decreased number. Conversely,...
This study aimed to explore the effective utilization of clarithromycin (CLA) through development clarithromycin-loaded solid lipid nanoparticles (CLA-loaded SLN), designed for nebulizer-based delivery first time. Wistar albino rats were divided into seven groups (n=8) based on time points (0.5, 1, 2, 4, 12, 24 hours, and a control group). At respective points, lung tissues blood samples collected analyzed CLA concentrations using HPLC-MS/MS. The maximum serum concentration (Cmax) was 6.74...
Possible protective effects of carvacrol (Car) against cyclophosphamide (CP)-induced cardiotoxicity was examined in this study. Experimental groups the rats were randomly divided into 13 groups,each including seven animals: Group 1 (control) treated with saline; 2, 3, and 4 50, 100, or 150 mg/kg CP, respectively; group 5 0.5 mL olive oil; 6 7 5.0 10 Car, 8, 9, respective CP plus Car; 11, 12, Car. Serum alanine transaminase (ALT),aspartat (AST), lactate dehydrogenase (LDH), malondialdehyde...
Cyclophosphamide (CTX) is the most commonly used effective alkylating drug in cancer treatment, but its use restricted because toxic side effect causes testicular toxicity. CTX disrupts tissue redox and antioxidant balance resulting damage oxidative stress. In our study based on this problem, kefir against CTX-induced stress toxicity were investigated. Rats divided into 6 groups: control, 150 mg/kg CTX, 5 10 kefir, + CTX. While fermented kefirs mixed given to rats for 12 days, was as a...
Cyclophosphamide (CP) is an antineoplastic drug that induces kidney damage via producing oxidative stress. Carvacrol (CAR) has antioxidative effect and we postulated it can be protective against CP-induced nephrotoxicity. Six groups (n = 7) of rats (control, 100 mg/kg CP, CP+5 CAR, CP+10 5 10 CAR) were injected intraperitoneally. Serum malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), creatinine (CRE), total antioxidant capacity (TAC), oxidant state (TOS)...
Fermented prebiotic and probiotic products with kefir are very important to slow down prevent the growth of tumors treat cancer by stimulating immune response against tumor cells. Cyclophosphamide (CPx) is widely preferred in treatment but its effectiveness high doses restricted because side effects. The aim this study was investigate protective effects CPx-induced heart liver toxicity. In an experiment, 42 Wistar albino rats were divided into six groups: control (Group 1), group receiving...