A5058461730- Chemotherapy-induced organ toxicity mitigation
- Selenium in Biological Systems
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Genetic and Kidney Cyst Diseases
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Pregnancy and Medication Impact
- Medical and Biological Ozone Research
- Extracellular vesicles in disease
- Acute Lymphoblastic Leukemia research
- Cardiovascular Conditions and Treatments
- Osteoarthritis Treatment and Mechanisms
- Virus-based gene therapy research
- Epilepsy research and treatment
- Biomedical Research and Pathophysiology
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
- Acute Myocardial Infarction Research
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Renal Transplantation Outcomes and Treatments
- Electrolyte and hormonal disorders
- Transplantation: Methods and Outcomes
Eskişehir Osmangazi University
2009-2024
Novartis (Switzerland)
2024
Stem Cell Institute
2023
Eskişehir City Hospital
2022-2023
Novartis (Italy)
2022
Kırıkkale University
2016
Despite advances in early detection and treatment, colorectal cancer remains one of the leading causes cancer-related deaths. The klotho (KL) gene plays a critical role development progression cancer. This study investigates KL by using CRISPR/Cas9 system to overexpress knock out (KO) human cells (Caco-2). effects changes were assessed expression analysis, flow cytometry, scratch wound closure assays, colony formation immunofluorescence staining. Our results showed that overexpression...
Introduction Chronic graft-versus-host disease (cGvHD) is a serious late complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods This multicenter analysis determined the cumulative incidence (CI) cGvHD and acute GvHD (laGvHD) its impact on transplantation-related mortality (TRM), relapse (R), overall survival (OS) in 317 patients [296 adults, 21 pediatrics (<12 years age)] who underwent their first allo-HSCT 2017. Results The CI laGvHD was 10.5% adults...
Cyclophosphamide (CP) is an antineoplastic drug that induces kidney damage via producing oxidative stress. Carvacrol (CAR) has antioxidative effect and we postulated it can be protective against CP-induced nephrotoxicity. Six groups (n = 7) of rats (control, 100 mg/kg CP, CP+5 CAR, CP+10 5 10 CAR) were injected intraperitoneally. Serum malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), creatinine (CRE), total antioxidant capacity (TAC), oxidant state (TOS)...
Permanent injury to corneal limbal stem cells after ocular surface chemical and thermal injuries is a major cause of blindness. In this study, PRP-laden GelMA hydrogel contact lens manufactured which aimed support the niche insults thereby preventing cell failure. with varying platelet-rich plasma (PRP) concentrations (5%, 10%, 20%) photopolymerized using visible light crosslinking system followed by characterizations mechanical properties, growth factor release, enzymatic degradation, in...
Cyclophosphamide (CP) is a widely used antineoplastic drug that causes toxicity in the normal cell due to its metabolites. The major drawback of this an undesirable myelosuppression. Selenium (Se) potent nutritional antioxidant carries out biological effects by incorporation into selenoproteins, such as glutathione peroxidase (GPx). possible protective seleno-l-methionine (SLM) against CP-related blood cells and bone marrow rats were investigated study. Intraperitoneal (i.p) administration...
The aim of this study was to assess the role serum cardiac troponin I (cTnI), T (cTnT), lactate dehydrogenase (LDH) and MB isoenzyme CK (CK-MB) concentrations in detection injury dogs with chronic mitral valve disease (CMVD). Fiftyfive echocardiographic diagnosis CMVD defined as thrill (Ct) non-cardiac (nCt) by auscultation-palpation, ten control were studied. Serum extracted from a blood sample each dog. Analysis cTnI, cTnT, LDH CK-MB performed. Mean ± SD cTnI concentration 1.9 0.38 ng/mL...
Cartilage injuries are currently the most prevalent joint disease. Previous studies have emphasized use of stem cells as effective treatment for regenerating cartilage damage.
ÖZET: Siklofosfamid (CP)'in antitümör etkinliği dozu ile doğru orantılıdır.Bununla birlikte, yüksek dozlarda yaygın sitotoksisitelere neden olur.Selenyum (Se) yapısına katıldığı glutatyon peroksidaz gibi selenoproteinler yoluyla potansiyel besinsel bir antioksidan olarak biyolojik etkiler göstermektedir.Bu nedenle siklofosfamid nedenli hepatotoksisitede selenyumun olası koruyucu etkisinin araştırılması amaçlanmıştır.Toplam 42 adet erkek Spraque-Dawley sıçan 6 gruba (n=7) ayrıldı (kontrol,...
Cyclophosphamide (CP) is an effective drug widely used for treating clinical cancer and non-malignant diseases. However, using CP causes cytotoxicity in one or more tissues. The present study aims to investigate possible protective effects of Carvacrol (Cr), which essential component thyme also known its antioxidant properties, upon testis toxicity. For this study, 35 male rats were categorized into 5 groups, each them including 7 members. Blood samples tissues obtained from animal the...
Abstract Due to their high expression profile of multi‐drug resistance genes, cancer stem cells (CSCs) are the main source drug resistance. The aim this study was establish a gemcitabine‐hydrochloride‐resistant (rt) human non‐small cell lung (hNSCLC) line and CSC be used as disease models in various studies. In first phase study, gemcitabine hydrochloride‐rt hNSCLC produced by making them rt through periodic exposure hydrochloride. This acquired gemcitabine‐hydrochloride‐rt characterized for...
Abstract Steroid-refractory acute graft-versus-host disease (aGvHD) is a serious complication after allogeneic hematopoietic stem cell transplantation, associated with significant mortality. Ruxolitinib was the first drug approved for aGvHD, based on results of REACH2 trial; however, real-world data are limited. We retrospectively analyzed safety and efficacy ruxolitinib treatment aGvHD at our center from March 2016 to August 2022 assessed biomarkers risk. identified 49 patients receiving as...
Kolorektal kanser dünyada en sık görülen gastrointestinal türüdür. Klotho, bedende fosfat ve kalsiyum homeostazının düzenlenmesinde önemli rol oynayan, hormon görevi de gören yaşlanma karşıtı glikozile edilmiş transmembran bir proteindir. Klotho sadece "yaşlanma baskılayıcı" olarak işlev görmez, aynı zamanda hücrenin hayatta kalmasını çoğalmasını da düzenler metastazında oynayan potansiyel tümör baskılayıcı görev yapar. Bu durum, yaşlanmanın benzer moleküler özellikleri paylaştığı...
Abstract Several studies have shown that klotho protein plays an important role in tumorigenesis concerning cell viability, proliferation, senescence, survival, autophagy, and resistance to antitumor therapies. From the literature, there is no study has been analyzed induces cytotoxic effects on human colorectal adenocarcinoma or healthy colon cells. We aimed investigate anticancer of against cells selectivity using by adding exogenously medium HT-29 cancer CCD 841 CoN lines analyzing its...
Background: Chronic graft-vs-host disease (cGVHD) is a major complication in recipients of allogeneic stem cell transplants. The recommended treatment for moderate/severe cGVHD systemic corticosteroids (CS) ± calcineurin inhibitor (CNI). However, limiting exposure to CS advised due high morbidity and poor quality life associated with treatment. Additionally, ≈50% patients (pts) become refractory/dependent (SR/D), requiring second-line Ruxolitinib (RUX), JAK1/2 inhibitor, demonstrated...
Klotho is a transmembrane protein which deficiency has pleiotropic effects in number of aging-related disease processes and various cancers. In some recent studies about klotho disorders, it been shown to effective cancers including lung, liver, breast, kidney, colon. TNF-related apoptosis-inducing ligand (TRAIL), TNF family molecule, cytokine that stimulates apoptosis through death receptors many cancer types therefore attracts attention for tumor therapies preclinical models. Interaction...