A5031472834- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Sleep and Wakefulness Research
- Psychedelics and Drug Studies
- Chemical synthesis and alkaloids
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Axon Guidance and Neuronal Signaling
- Diet and metabolism studies
- Retinal Development and Disorders
- Visual perception and processing mechanisms
- Neuroscience and Neural Engineering
Oregon Health & Science University
2023-2024
Brandeis University
2016-2020
Psilocybin has been shown to improve symptoms of depression and anxiety when combined with psychotherapy or other clinician-guided interventions. To understand the neural basis for this pattern clinical efficacy, experimental conceptual approaches that are different than traditional laboratory models needed. A potential novel mechanism is acute psilocybin improves cognitive flexibility, which then enhances impact clinician-assisted Consistent idea, we find robustly flexibility in male female...
Significance The firing dynamics of neurons in primary visual cortex (V1) are poorly understood. Indeed, V1 freely behaving rats fire at the same mean rate light and darkness. It is unclear how this stability maintained whether it important for sensory processing. We find that transitions between darkness happening expected times have only modest effects on activity. In contrast, both unexpected reexposure after extended robustly increase firing. Finally, pairwise correlations neuronal...
Abstract Psilocybin has been shown to improve symptoms of depression and anxiety when combined with psychotherapy or other clinician-guided interventions. To understand the neural basis for this pattern clinical efficacy, experimental conceptual approaches that are different than traditional laboratory models needed. A potential novel mechanism is acute psilocybin improves cognitive flexibility, which then enhances impact clinician-assisted Consistent idea, we find robustly flexibility in...
Abstract Adolescence is characterized by increased impulsive and risk-taking behaviors. To better understand the neural networks that subserves impulsivity in adolescents, we used a reward-guided behavioral model quantifies age differences actions adult adolescent rats of both sexes. Using chemogenetics, identified orbitofrontal cortex (OFC) projections to dorsomedial striatum (DMS) as critical pathway for age-related execution actions. Simultaneous recording single units local field...
SUMMARY Homeostatic plasticity is hypothesized to regulate neuronal activity around a stable set point compensate for learning-related plasticity. This regulation predicted be bidirectional but only upward firing rate homeostasis (FRH) has been demonstrated in vivo . We combined chronic electrophysiology freely behaving animals with protocol that induces robust primary visual cortex (V1) induce downward FRH and show neurons bidirectionally rates an individual point. Downward did not require...
Summary Mutations in Shank3 are strongly associated with autism spectrum disorders and circuit disfunction, but a unified view of how loss disrupts function excitability is lacking. Stabilizing, homeostatic forms synaptic intrinsic plasticity critical for preventing hyper- or hypo-excitability, leading us to ask whether perturbs circuits by disrupting plasticity. We show that abolishes plasticity, which can be rescued lithium(Li), drug therapeutic potential human Shankopathies. Further, vivo...
Psychosis is a hallmark of schizophrenia. It typically emerges in late adolescence and associated with dopamine abnormalities aberrant salience. Most genes schizophrenia risk involve ubiquitous targets that may not explain delayed emergence dopaminergic disruptions. This includes
The dynamics of neuronal firing during natural vision are poorly understood. Surprisingly, mean rates neurons in primary visual cortex (V1) freely behaving rodents similar prolonged periods light and darkness, but it is unknown whether this reflects a slow adaptation to changes input, or insensitivity rapid drive. Here we use chronic electrophysiology rats either sex follow individual V1 across many dark-light (D-L) light-dark (L-D) transitions. We show that, even on timescales (1s 10 min),...
Monocular deprivation (MD), a well-established tool for studying plasticity in the visual cortex, induces biphasic response neural activity. Initially, neuronal firing rates (FRs) are suppressed by widespread Hebbian LTD. Following FR suppression extended MD, homeostatic mechanisms restore spiking precisely to baseline levels. We recently demonstrated that return set-point is expressed during waking and not sleep. Here we address role of arousal-states environmental variables gating...