ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared detection of xenon dichlorideLeonard Y. Nelson and George C. PimentelCite this: Inorg. Chem. 1967, 6, 9, 1758–1759Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/ic50055a038https://doi.org/10.1021/ic50055a038research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations74LEARN ABOUT THESE METRICSArticle...

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Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas. Understanding how the properties excitation light source and PpIX fluorescence interact with surgical microscope critical effective use tumor technique. In this study, we performed detailed assessment intensity emitted blue white beam profile clinical grade operating microscopes visualization. These measurements revealed both...

Fluorescence molecular imaging with exogenous probes improves specificity for the detection of diseased tissues by targeting unambiguous signatures. Additionally, increased diagnostic sensitivity is expected application multiple probes. We developed a real-time multispectral fluorescence-reflectance scanning fiber endoscope (SFE) wide-field fluorescent dye-labeled at nanomolar levels. Concurrent multichannel SFE also allows mitigation background autofluorescence (AF) signal, especially when...

The number of molecular species suitable for multispectral fluorescence imaging is limited due to the overlap emission spectra indicator fluorophores, e.g., dyes and nanoparticles. To remove fluorophore cross-talk in wide-field imaging, we evaluate three different solutions: (1) image stitching, (2) concurrent with ratio subtraction algorithm, (3) frame-sequential imaging. A phantom fabricated, a 1.2-mm ultrathin scanning fiber endoscope (SFE) used test compare these approaches. Results show...

Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation L. Y. Nelson, A. W. Saunders, B. Harvey, G. O. Neely; Detection of Vibrationally Excited Homonuclear Diatomic Molecules by Raman Spectroscopy. J. Chem. Phys. 15 November 1971; 55 (10): 5127–5128. https://doi.org/10.1063/1.1675633 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley...

An experimental investigation of basic aspects the tapered-wiggler free-electron laser (FEL) is described. The electron energy distribution resulting from interaction measured in a single pass amplifier configuration using CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> laser. This consistent with an loss, for some electrons, equal to change resonant entrance exit wiggler. A net deceleration 2.5 percent has been achieved, compared...

There is currently a need for safe and effective way to detect diagnose early stages of childhood caries. A multimodal optical clinical prototype diagnosing caries demineralization in vivo has been developed. The device can be used quickly image screen any signs demineralized enamel by obtaining high-resolution high-contrast surface images using 405-nm laser as the illumination source, well autofluorescence bacterial fluorescence images. When suspicious region located, also performs dual...

Autofluorescence spectra were recorded in vitro from dentin, enamel, and whole teeth. The exhibited a broad peak shifted by about 50 to 75 nm the excitation wavelength shape of remained similar regardless wavelength. maximum autofluorescence also red-shift that depended upon laser amplitude red-shifted fluorescence produced 444 532 lasers compared 405 laser. It was determined not proportional inverse fourth power Therefore, is compatible with previously proposed mechanism Raman scattering....

We developed a stable, reproducible three-dimensional optical phantom for the evaluation of wide-field endoscopic molecular imaging system. This mimicked human esophagus structure with flexibility to demonstrate body movements. At same time, realistic visual appearance and diffuse spectral reflectance properties tissue were simulated by color matching methodology. A photostable dye-in-polymer technology was applied represent biomarker probed “hot-spot” locations. Furthermore, fluorescent...

Previous N2 and H2 electronic transition lasers have been limited to short pulse durations (10−9–10−7 sec). Using an electron-beam-stabilized discharge in argon, nitrogen (or hydrogen), hydrogen fluoride mixtures, we observed repetitive superfluorescent pulses lasting 5–20 μsec. Optical-cavity measurements verify that optical gain is present throughout the duration at wavelengths first- second-positive band systems a near-infrared system. It believed HF serves maintain population inversion...

An ultrathin scanning fiber endoscope, originally developed for cancer diagnosis, was used to image dental occlusal surfaces as well shallow artificially induced enamel erosions from human extracted teeth (n = 40). Enhanced resolution of obtained using a short-wavelength 405-nm illumination laser. In addition, artificial varying depths were also imaged with 405-, 404-, 532-, and 635-nm lasers. Laser-induced autofluorescence images the obtained. Contrast between sound eroded quantitatively...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared spectra of chlorine-bromine polyhalogens by matrix isolationLeonard Y. Nelson and George C. PimentelCite this: Inorg. Chem. 1968, 7, 9, 1695–1699Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/ic50067a001https://doi.org/10.1021/ic50067a001research-articleACS PublicationsRequest reuse permissionsArticle...

An ultrathin scanning fiber endoscope, originally developed for cancer diagnosis, was used in a case study to locate plaque and caries. The imaging system incorporated software mitigation of background auto-fluorescence (AF). In conventional fluorescence imaging, varying AF across tooth surface can mask low-level porphyrin signals. Laser-induced signals dental tissue excited using 405-nm laser typically produce over wavelength range extending from 440-nm 750-nm. Anaerobic bacterial...

Medical adhesives are used to secure wound care dressings and other critical devices the skin. Without means of safe removal, these stronger difficult painlessly remove from skin may cause medical-adhesive-related injuries (MARSI), including tears an increased risk infection. Lower-adhesion medical tapes be applied avoid MARSI, leading device dislodgement further complications. This paper outlines development a high-adhesion tape designed for low trauma upon release. By warming skin-attached...

We present a spectroscopic and morphological study of the deposition mono-, di-, triester fluorophosphate films on alumina surfaces. Solid-state NMR Fourier transform infrared characterization show that species capable forming three P−O−Al linkages are favored over mono- bidentate binding moieties during adsorption process. Our results indicate film formation in conjunction with local sonication greatly enhances resulting density homogeneity by removing weakly bound overcoming influence...

Although the availability of high-powered argon ion lasers has significantly reduced difficulty obtaining Raman spectra gases, nevertheless there are still many cases where enhancement scattered light from weakly scattering samples is required. One particular example in study vibrationally excited molecules produced thermally1 and an electrical discharge.2, 3 Because concentration species not very high, standard methods laser excitation do provide sufficiently intense spectra. In this note,...

Fluorescence-labeled molecular probes can be used during endoscopy for early cancer detection. As many tumors express multiple cell surface markers and these signatures are heterogeneous across patients, simultaneous imaging of numerous different targets is important increasing the sensitivity diagnosis personalized treatment. For this purpose, a wide-field, multi-spectral fluorescence-reflectance scanning fiber endoscope (SFE) has been developed. Using set calibrated fluorescent test at in...

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Bacteria in the dental biofilm produceacid after consumption of carbohydrates which if left unmonitored leads to caries formation. We present O-pH, a device that can measure acidity and provide quantitative feedback assist oral health monitoring. xmlns:xlink="http://www.w3.org/1999/xlink">Method:</i> O-pH utilizes ratiometric pH sensing method by capturing fluorescence Sodium...

Sugar-rich diets and poor dental hygiene promote the formation of a biofilm (plaque) that strongly adheres to enamel surface fosters evolution aciduric bacteria. The acid contributes demineralization exterior tooth enamel, which accelerates after pH drops below critical value (∼5.5) for extended time periods resulting in need restorative procedures. Preventative techniques alert dentist caries-susceptible patients regarding vulnerability decay require clinical measure plaque activity....

Using a high-current long-pulse electron-beam-stabilized electrical discharge, laser oscillation has been observed on several vibration-rotation bands of HF and DF in mixtures containing less than 1% or DF. Results HF/argon with 10% added N2, H2, D2 established that is vibrationally pumped by direct electron impact also vibrational energy transfer from H2. Rotational nonequilibrium as well cascade coupling between 3 → 2 lines 1 were inferred the time sequence emission.