A5041060374- Genomics and Phylogenetic Studies
- AI in cancer detection
- RNA and protein synthesis mechanisms
- COVID-19 and healthcare impacts
- Digital Imaging for Blood Diseases
- Machine Learning in Bioinformatics
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Molecular Biology Techniques and Applications
- Knee injuries and reconstruction techniques
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Advanced Proteomics Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Metabolomics and Mass Spectrometry Studies
- Hip disorders and treatments
- Trauma and Emergency Care Studies
- Osteoarthritis Treatment and Mechanisms
- Sports injuries and prevention
- Dermatological and COVID-19 studies
- Genomics and Chromatin Dynamics
- vaccines and immunoinformatics approaches
- Musculoskeletal synovial abnormalities and treatments
Pennsylvania State University
2023-2025
Penn State Milton S. Hershey Medical Center
2023-2024
Hospital for Special Surgery
2020-2023
Cornell University
2020
Coronavirus disease 2019 (COVID-19) is an emerging pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although majority of patients who become infected with SARS-CoV-2 are asymptomatic or have mild symptoms, some develop symptoms that can permanently detract from their quality life. closely related to SARS-CoV-1, which causes (SARS). Both viruses infect system, and there direct indirect effects this infection on multiple organ systems, including...
The rapid progression of genomics and proteomics has been driven by the advent advanced sequencing technologies, large, diverse, readily available omics datasets, evolution computational data processing capabilities. vast amount generated these advancements necessitates efficient algorithms to extract meaningful information. K-mers serve as a valuable tool when working with large offering several advantages in speed memory efficiency carrying potential for intrinsic biological functionality....
To evaluate inpatient outcomes among patients with hip fracture treated during the COVID-19 pandemic in New York City.Multicenter retrospective cohort study.One Level 1 trauma center and one orthopaedic specialty hospital City.Fifty-nine consecutive (average age 85 years, range: 65-100 years) for a (OTA/AO 31, 32.1) over 5-week period, March 20, 2020, to April 24, height of crisis.COVID-19 infection status was used stratify patients. The primary outcome mortality. Secondary were admission...
Background: The long incubation period and asymptomatic spread of COVID-19 present considerable challenges for health-care institutions. identification infected individuals is vital to prevent the illness staff other patients as well identify those who may be at risk disease-related complications. This particularly relevant with resumption elective orthopaedic surgery around world. We report results a universal testing protocol in undergoing during coronavirus pandemic describe postoperative...
Despite the exponential increase in sequencing information driven by massively parallel DNA technologies, universal and succinct genomic fingerprints for each organism are still missing. Identifying shortest species-specific nucleotide sequences offers insights into species evolution holds potential practical applications agriculture, wildlife conservation, healthcare. We propose a new method sequence analysis termed nucleic “quasi-primes,” occurring of 45,076 organismal reference genomes,...
Massively parallel reporter assays (MPRAs) represent a set of high-throughput technologies that measure the functional effects thousands sequences/variants on gene regulatory activity. There are several different variations MPRA technology and they used for numerous applications, including element discovery, variant effect measurement, saturation mutagenesis, synthetic generation or characterization evolutionary differences. Despite their many designs uses, there is no comprehensive database...
Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disorder in which patients suffer from inflammatory-erosive arthritis. Recent advances on histopathology heterogeneity of RA synovial tissue revealed three distinct phenotypes based cellular composition (pauci-immune, diffuse and lymphoid), suggesting that etiologies warrant specific targeted therapy motivates need for cost effective phenotyping tools preclinical clinical settings. To this end, we developed an automated...
Abstract The prevalence of nucleic and peptide short sequences across organismal genomes proteomes has not been thoroughly investigated. We examined 45 785 reference 21 871 proteomes, spanning archaea, bacteria, eukaryotes viruses to calculate the rarity in them. To capture this, we developed a metric each sequence nature, index. find that frequency certain dipeptides rare oligopeptide is hundreds times lower than expected, which case for any dinucleotides. also generate predictive...
The decrease in sequencing expenses has facilitated the creation of reference genomes and proteomes for an expanding array organisms. Nevertheless, no established repository that details organism-specific genomic proteomic sequences specific lengths, referred to as kmers, exists our knowledge. In this article, we present kmerDB, a database accessible through interactive web interface provides kmer-based information from systematic way. kmerDB currently contains 202,340,859,107 base pairs...
Background: Anterior cruciate ligament (ACL) tears are common knee injuries. Despite undergoing extensive rehabilitation after ACL reconstruction (ACLR), many patients have persistent quadriceps muscle weakness that limits their successful return to play and also at an increased risk of developing osteoarthritis (OA). Human growth hormone (HGH) has been shown prevent atrophy in various models disuse disease but not evaluated ACLR. Hypothesis: Compared with placebo treatment, a 6-week...
Abstract Massively parallel reporter assays (MPRAs) represent a set of high-throughput technologies that measure the functional effects thousands sequences/variants on gene regulatory activity. There are several different variations MPRA technology and they used for numerous applications, including element discovery, variant effect measurement, saturation mutagenesis, synthetic generation or characterization evolutionary differences. Despite their many designs uses, there is no comprehensive...
Abstract Early detection of human disease is associated with improved clinical outcomes. However, many diseases are often detected at an advanced, symptomatic stage where patients past efficacious treatment periods and can result in less favorable Therefore, methods that accurately detect a presymptomatic urgently needed. Here, we introduce “frequentmers”; short sequences specific recurrently observed either patient or healthy control samples, but not both. We showcase the utility...
Abstract The prevalence of nucleic and peptide short sequences across organismal genomes proteomes has not been thoroughly investigated. Here we examined 45,785 reference 21,871 proteomes, spanning archaea, bacteria, viruses eukaryotes to calculate the rarity in them. To capture this, developed a metric each sequence nature, Anti-Kardashian index. We find that frequency certain dipeptides rare oligopeptide is hundreds times lower than expected, which case for any dinucleotides. also generate...
ABSTRACT The rapid decline in sequencing cost has enabled the generation of reference genomes and proteomes for a growing number organisms. However, at present time, there is no established repository that provides information about organism-specific genomic proteomic sequences certain lengths, also known as kmers, are either or absent each genome proteome. In this article, we kmerDB, database accessible through an interactive web interface kmer based from systematic way. kmerDB currently...
The coronavirus disease 19 (COVID-19) pandemic had a devastating effect on New York City in the spring of 2020. Several global reports suggested worse early outcomes among COVID-positive patients with hip fractures. However, there is limited data comparing baseline comorbidities treated during relative to those non-pandemic conditions.A multicenter retrospective cohort study was performed at two Level 1 Trauma centers and one orthopedic specialty hospital assess demographics, comorbidities,...
Abstract Early detection of human disease is associated with improved clinical outcomes. However, many diseases are often detected at an advanced, symptomatic stage where patients past efficacious treatment periods and can result in less favorable Therefore, methods that accurately detect a presymptomatic urgently needed. Here, we introduce “frequentmers”; short sequences specific recurrently observed either patient or healthy control samples, but not both. We showcase the utility...
Abstract Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disorder in which patients suffer from inflammatory-erosive arthritis. Recent advances on histopathology heterogeneity of RA pannus tissue revealed three distinct phenotypes based cellular composition (pauci-immune, diffuse and lymphoid), suggesting etiologies that warrant specific targeted therapy. Thus, cost-effective alternatives to clinical pathology phenotyping are needed for research disparate healthcare. To...
Objectives: Patients with Femoroacetabular impingement (FAI) have been shown to elevated circulating biomarkers of inflammation and cartilage catabolism, but little is known about whether corrective surgical intervention improves objective measures hip strength inflammation. This study measured several variables including pain, function, quality life, symptoms, strength, inflammatory in a cohort subjects undergoing FAI surgery postoperative (postop) rehabilitation. We hypothesized that...
Background: Patients with symptomatic femoroacetabular impingement (FAI) have hip strength deficits, instability, and increased risk for concomitant injury. While surgical intervention is an effective method of treatment FAI, more information needed about the recovery process. Purposes: We sought to understand how patients FAI recover from correction in short term. Do patients’ perceptions improvement correspond measured improvements strength? Methods: conducted a prospective cohort study 17...