A5004023285- Breastfeeding Practices and Influences
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Pharmaceutical studies and practices
- Child Nutrition and Feeding Issues
- Pregnancy and Medication Impact
- Diabetes Management and Research
- Diabetes Treatment and Management
- Attention Deficit Hyperactivity Disorder
- Gastroesophageal reflux and treatments
- Medication Adherence and Compliance
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Pharmaceutical Economics and Policy
- Child and Adolescent Psychosocial and Emotional Development
- Respiratory and Cough-Related Research
- Neuroscience of respiration and sleep
- Adolescent and Pediatric Healthcare
- Bipolar Disorder and Treatment
- Sleep and Wakefulness Research
- Analytical Methods in Pharmaceuticals
- Sleep and related disorders
- Folate and B Vitamins Research
- Infant Nutrition and Health
SA Health
2016-2022
Women's and Children's Hospital
2014-2022
The University of Adelaide
2017
Boston Children's Hospital
2011-2015
Abstract Context Children with type 1 diabetes have vascular dysfunction preceding atherosclerosis. Early interventions are needed to reduce cardiovascular disease. Objective To evaluate the effect of metformin on function in children diabetes. Design Twelve-month double-blind, randomized, placebo-controlled trial. Setting Tertiary pediatric clinic. Participants Ninety (8 18 years age), >50th percentile body mass index (BMI), Intervention Metformin (up g twice a day) or placebo. Main...
Introduction: Rosuvastatin reduces concentrations of total cholesterol (TC) and is used for the management hypercholesterolemia prevention acute coronary syndromes. There are no published reports estimating infant exposure to rosuvastatin through breast milk. Purpose: The aims this study were quantify in human milk plasma from a lactating woman taking investigate potential exposure. Materials methods: A 38-year-old breastfeeding mother was commenced on 20 mg daily secondary an syndrome....
To gain insight into the treatment experiences of children and adolescents diagnosed with attention-deficit/hyperactivity disorder (ADHD).Convenience sampling was used to recruit eligible parents carers at paediatric clinics Children's, Youth Women's Health Service participate in an interview discuss experiences, using a semi-structured questionnaire.Thirty-five interviews were conducted. Twenty-five subjects had trialled average 1.5 interventions prior receiving ADHD diagnosis, namely,...
Background: Few studies have investigated breastfeeding outcomes among women exposed to antidepressants. Research aim: This study aimed evaluate the association between antidepressant use in late gestation and maternal psychiatric illness on rates at discharge from hospital. Methods: The authors conducted a retrospective cohort of 32,662 delivering live-born singletons January 2001 December 2008. Electronic hospital records were used obtain data exposure during whether mothers following...
A new sensitive LC-MS/MS method for the quantification of atenolol in human plasma and milk has been developed clinical lactation studies.Atenolol internal standard, phenazone, were extracted from biological matrices by protein precipitation. Phenomenex® C-18 column gradient chromatographic conditions used separation analyte, followed detection with MS. Stability samples was confirmed up to 3 months. Linearity range 1-800 ng/ml (r2 = 0.9995), precision within 15% CV recovery analyte (80-100%...
Background Non-adherence to treatment in childhood chronic illness has serious consequences for health and healthcare costs. Accurate detailed objective data on adherence are minimal this age group. Objective To evaluate medication using electronic monitoring systems children with type 1 diabetes (T1D). Design A cohort study of 90 T1D (aged 13.6±2.5 years, 41 males) from two paediatric clinics, participated a 12-month double-blind, randomised, placebo-controlled trial (1:1 allocation). This...
The aims of the present study were to examine association between late pregnancy exposure serotonin reuptake inhibitor (SRI) antidepressants and difficulties in achieving an adequate breast milk supply women who have given birth preterm infants, while accounting for potential impacts underlying maternal psychiatric illness.A retrospective cohort was carried out 3024 delivering liveborn infants (<37 weeks' gestation) January 2004 December 2008. primary outcome postnatal domperidone use,...
Background: Atenolol lactation information is limited, and controversy exists over the safety of its use during breastfeeding. In this study, important parameters including milk-to-plasma ratio, ratio infant plasma to maternal plasma, daily dosage, relative dose were investigated. The findings from study add existing data about atenolol transfer in human milk. This may help guide health professionals decision making regarding beta blockers used by mothers Research aim: aims quantify...
Objective: This study aimed to quantify the amount of perindopril and its active metabolite perindoprilat present in breast milk corresponding maternal infant plasma concentrations. Design: Prospective, longitudinal, observational. Setting: Tertiary specialist paediatric obstetric hospital Adelaide, South Australia. Population: Breastfeeding women actively treated with for hypertensive disorders postpartum. Methods: Eight samples a single sample were collected from each participant over 24...
Narcolepsy, a condition adversely affecting psychological, social, and cognitive function, is more prevalent in females of childbearing age than the general population. Modafinil armodafinil are central nervous system stimulants approved for treatment narcolepsy. Infant exposure to these agents through human milk has not been investigated. Poor quality medication safety information during lactation associated with early cessation breastfeeding suboptimal healthcare family.In this case study,...
Background The use of proton pump inhibitors (PPIs) for the off-label treatment gastro-oesophageal reflux and ‘colic’ in infants has become increasing interest medical community mass media. Concerns are now being raised about whether PPI overused as evidence efficacy is lacking there concerns long-term adverse effects. Aim To assess extent indications prescribing PPIs infants, a tertiary paediatric hospital. Method Two audits were undertaken (1) retrospective audit dispensing data over 10...
Treatment adherence during adolescence is challenging. Limited data exist for the rate of medication in adolescents.