A5015066907- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Acute Kidney Injury Research
- Muscle and Compartmental Disorders
- COVID-19 Clinical Research Studies
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Cancer, Lipids, and Metabolism
- Sperm and Testicular Function
- Advanced machining processes and optimization
- Advanced Machining and Optimization Techniques
- Metallurgy and Material Forming
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Insect and Arachnid Ecology and Behavior
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- Genetics and Physical Performance
- Cardiac Fibrosis and Remodeling
- Genomics and Rare Diseases
- Endoplasmic Reticulum Stress and Disease
Duke University
2020-2025
Zhejiang University
2022-2023
Xi'an Technological University
2023
Chongqing Medical University
2017-2022
Xiangya Hospital Central South University
2019-2021
Central South University
2019-2021
University of Maryland, College Park
2020
Physical Sciences (United States)
2020
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2020
BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is one of the leading causes sudden cardiac death in children, young adults, and athletes characterized by fibro-fatty replacement myocardium, predominantly right ventricle. Sixty percent patients with ACM have a known genetic cause, but for remainder, etiology unknown. This lack mechanistic understanding has also slowed development disease-modifying therapies, children high degree morbidity mortality. METHODS: Induced pluripotent stem cells...
Cardiac fibrosis is the most important mechanism contributing to cardiac remodeling after myocardial infarction (MI). VPO1 a heme enzyme that uses hydrogen peroxide (H2O2) produce hypochlorous acid (HOCl). Our previous study has demonstrated regulates ischemic reperfusion and renal fibrosis. We investigated role of in MI. The results showed expression was robustly upregulated failing human heart with cardiomyopathy murine model MI accompanied by severe Most importantly, knockdown tail vein...
Background Pediatric-onset restrictive cardiomyopathy (RCM) is associated with high mortality, but underlying mechanisms of disease are under investigated. RCM-associated diastolic dysfunction secondary to variants in TNNT2-encoded cardiac troponin T (TNNT2) poorly described. Methods and Results Genetic analysis a proband kindred RCM identified TNNT2-R94C, which cosegregated family 2 generations RCM, ventricular arrhythmias, sudden death. TNNT2-R94C was absent among large, population-based...
Spontaneously depolarizing nodal cells comprise the pacemaker of heart. Intracellular calcium (Ca
Junctional ectopic tachycardia (JET) is a potentially fatal cardiac arrhythmia. Hcn4:shJph2 mice serve as model of nodal arrhythmias driven by ryanodine type 2 receptor (RyR2)-mediated Ca
Background As utilization of clinical exome sequencing (ES) has expanded, criteria for evaluating the diagnostic weight incidentally identified variants are critical to guide clinicians and researchers. This is particularly important in genes associated with dilated cardiomyopathy (DCM), which can cause heart failure sudden death. We sought compare frequency distribution DCM-associated between a referral cohort those control known case cohorts determine likelihood pathogenicity among...
Ras and a-factor-converting enzyme 1 (Rce1) is located in the endoplasmic reticulum (ER) thought to be responsible for endoproteolytic processing of vast majority CAAX proteins. Endoplasmic stress (ERS) plays an important role renal cell carcinoma (RCC); however, expression Rce1 RCC have not been extensively studied. We aimed investigate tissues its molecular mechanism ERS-induced apoptosis 786-O cells. first used western blotting, quantitative reverse transcriptase-polymerase chain...
This work examined microRNA-1290 (miR-1290)'s effect on regulating the malignant phenotype of prostate cancer (PC) cells. We detected miR-1290 expression within PC based open-sourced datasets as well in cells and tissues. Loss-of-function experiments by knockdown cell lines were performed. performed CCK-8, clone forming, Transwell, sphere formation assays for examining cells' phenotypes following knockdown. estimated miR-1290's target genes using online resources including miRDB, miRbase,...
Citron kinase (CIT) is a Rho‑effector protein that associated with several types of cancer. However, the role CIT in prostate cancer (PCa) unclear. The current study utilized microarray data obtained from Cancer Genome Atlas, which was analyzed via Biometric Research Program array tools. Additionally, reverse transcription‑quantitative (RT‑q)PCR performed to compare mRNA expression PCa tissue and benign prostatic hyperplasia. detected consecutive cohort immunochemistry screened as potential...
Abstract Sperm are one of the most morphologically diverse cell types in nature, yet they also exhibit remarkable behavioral variation, including formation collective groups cells that swim together for motility or transport through female reproductive tract. Here we take advantage natural variation sperm traits observed across Peromyscus mice to test hypothesis morphology rodent head influences their aggregation behavior. Using machine learning and traditional morphometric approaches...
Abstract A landing gear is the main large bearing structural part of an aircraft. The change material and structure makes processing aircraft more difficult. Aiming at characteristics deep cavity, hole technique a 300M steel workpiece was studied. separated NC drilling boring machine adopted to process workpiece. Cavity special cutting tools were introduced. Fixture sealing mode improved. programs optimized. Thus, problems deflection, vibration, chip breaking removal solved. with width...
Introduction: Arrhythmogenic cardiomyopathy (AC) is a heart muscle disease where fibrofatty tissue replaces healthy myocardium. AC predisposes to ventricular arrhythmias and sudden cardiac death. We identified biallelic variants in the TAX1BP3- encoded tax1-binding protein 3 (TAX1BP3) genetically elusive family with AC. TAX1BP3 has putative roles canonical Wnt signaling, but its function unknown. Our goal identify novel mechanisms of development develop therapeutics mitigate or reverse...