A5013422008- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Glycosylation and Glycoproteins Research
- Polysaccharides and Plant Cell Walls
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Advanced Cellulose Research Studies
- Advanced Biosensing Techniques and Applications
- biodegradable polymer synthesis and properties
- Asthma and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Coordination Chemistry and Organometallics
- Oral and Craniofacial Lesions
- Metalloenzymes and iron-sulfur proteins
- Bacteriophages and microbial interactions
- Synthetic Organic Chemistry Methods
- Proteoglycans and glycosaminoglycans research
- Respiratory and Cough-Related Research
- Enzyme Catalysis and Immobilization
- Neuroscience and Neuropharmacology Research
University of Pisa
2015-2022
Ospedale Maggiore
2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
Max Planck Institute of Colloids and Interfaces
2019-2020
Abstract A dense hydrogen‐bond network is responsible for the mechanical and structural properties of polysaccharides. Random derivatization alters bulk material by disrupting hydrogen bonds, but obstructs detailed structure–function correlations. We have prepared well‐defined unnatural oligosaccharides including methylated, deoxygenated, deoxyfluorinated, as well carboxymethylated cellulose chitin analogues with full control over degree pattern substitution. Molecular dynamics simulations...
Abstract Chitin, a polymer composed of β(1–4)‐linked N ‐acetyl‐glucosamine monomers, and its partially deacetylated analogue chitosan, are abundant biopolymers with outstanding mechanical as well elastic properties. Their degradation products, chitooligosaccharides (COS), can trigger the innate immune response in humans plants. Both material biological properties dependent on length, acetylation, pH. Without well‐defined samples, complete molecular description these factors is still missing....
Abstract Single glycan–protein interactions are often weak, such that glycan binding partners commonly utilize multiple, spatially defined sites to enhance avidity and specificity. Current array technologies usually neglect multivalent display. Laser‐based synthesis technology allows for flexible rapid on‐surface of different peptides. By combining this technique with click chemistry, neo‐glycopeptides were produced directly on a functionalized glass slide in the microarray format. Density...
This study reports on a preliminary structure–activity relationship exploration of 4-aryliden-2-methyloxazol-5(4H)-one-based compounds as MAGL/FAAH inhibitors. Our results highlight that this scaffold may serve for the development selective MAGL A 69-fold selectivity against over FAAH was achieved compound 16b (MAGL and IC50 = 1.6 111 µM, respectively). Furthermore, best behaved reversible ligand showed promising antiproliferative activity in cancer cells.
Stereoselectively synthesized real 1,2 pseudomannobiosides exhibit activities as DC-SIGN inhibitors by means of an SPR technique with potential applications antiviral agents.
Carba analogues of biologically relevant natural carbohydrates are promising structures for the development future drugs endowed with enhanced hydrolytic stability. An open synthetic challenge in this field is optimization new methodologies stereo- and regioselective opening α-gluco carbasugar 1,2-epoxides that allow preparation pseudo mono- disaccharides great interest. Therefore, we investigated effect Lewis acids solvate ionic liquids (SILs) on epoxide ring a model substrate. Of...
Laser-based patterning technology allows for flexible and rapid on-surface microarray synthesis of peptide scaffolds. In combination with click chemistry, a multitude neo-glycopeptides can be directly produced on functionalized glass slides in the format. Density spatial distribution carbohydrates easily tuned to obtain well-defined glycan structures multivalent display. Lectins reveal strong spacing-, density-, ligand-dependent binding these structures. More information found Full Paper by...
Abstract Treatment of dimethyl malonate with LiN(Tms) 2 generates the expected lithium enolate and methyl formate anion.