A5054966997- Inflammatory Bowel Disease
- Gut microbiota and health
- Bariatric Surgery and Outcomes
- Microscopic Colitis
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Body Contouring and Surgery
- Enhanced Recovery After Surgery
- Diverticular Disease and Complications
- Nosocomial Infections in ICU
- Probiotics and Fermented Foods
- Abdominal Surgery and Complications
- Appendicitis Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Digestive system and related health
- Obesity and Health Practices
- Colorectal Cancer Surgical Treatments
- Regulation of Appetite and Obesity
- Abdominal Trauma and Injuries
- Surgical site infection prevention
University of Alberta
2013-2023
University of Alberta Hospital
2021
American College of Surgeons
2018
Canadian Institutes of Health Research
2018
Health Sciences Centre
2017
Institute of Infection and Immunity
2017
Abstract Western-style diets have been implicated in triggering inflammatory bowel disease activity. The aim of this study was to identify the effect a short-term diet high sugar on susceptibility colitis. Adult wild-type mice were placed chow or (50% sucrose) ± acetate. After two days diet, treated with dextran sodium sulfate (DSS) induce Disease severity assessed daily. Colonic tissues analyzed for cytokine expression using MesoScale discovery platform. Intestinal permeability and serum...
Abstract Introduction : Many of the deleterious effects associated with chronic kidney disease (CKD) are secondary to resultant systemic inflammation. The gut microbial changes caused by CKD thought perpetuate Therefore, strategies aimed at modulating microbiota may be helpful in reducing complications CKD. We hypothesized that supplementation high‐amylose maize resistant starch type 2 (HAM‐RS2) would beneficially alter microbiome and lead lower levels Methods A double‐blind, parallel,...
Bariatric surgery induces significant microbial and metabolomic changes, however, links between metabolic pathways have not been fully elucidated. The objective of this study was to conduct a comprehensive investigation the microbial, metabolomic, inflammatory changes that occur following Roux-en-Y gastric bypass (RYGB) sleeve gastrectomy (SG). A prospective clinical trial conducted with participants undergoing RYGB, SG, non-operative controls (CTRL). Clinical parameters, blood samples,...
Background Fecal microbial transplantation (FMT) is used in the treatment of relapsing Clostridium difficile infection (rCDI). Failure rate for FMT as high 10% but mechanisms contributing to a failed are not understood. We utilized metagenomic data identify role bacteria and bacteriophages on success.Results Subjects with rCDI (n = 19) received from volunteer donors 7) via colonoscopy. Twelve patients fully recovered after single FMT, while seven required subsequent FMT. DNA was extracted...
Abstract Roux-en-Y gastric bypass (RYGB)-induced glycemic improvement is associated with increases in glucagon-like-peptide-1 (GLP-1) secreted from ileal L-cells. We analyzed changes bile acids and microbial composition diet-induced-obesity rats after RYGB or sham surgery to elucidate the early late effects on L-cells glucose homeostasis. In cohorts, there were no significant L-cell density, GLP-1 tolerance. demonstrated less weight regain, improved tolerance, increased villi height. No...
INTRODUCTION: The incidence of peptic ulcer disease (PUD) has been decreasing over time with Helicobacter pylori eradication and use acid-suppressing therapies. However, PUD remains a common cause hospitalization in the United States. We aimed to evaluate contemporary national trends incidence, treatment patterns, outcomes for PUD-related hospitalizations compare care delivery by hospital rurality. METHODS: Data from National Inpatient Sample were used estimate weighted annual rates...
Abstract Background Individuals with Crohn’s disease frequently require ileocecal resection (ICR), and inflammation often recurs in the neoterminal ileum following surgery. Fructooligosaccharide (FOS) is a fermentable prebiotic that stimulates growth of bifidobacteria may promote anti-inflammatory activity. The aim this study was to determine if supplementation postICR diet FOS mouse model would be effective stimulating reducing systemic local inflammation. Methods ICR performed IL10-/- mice...
The development of new therapies for inflammatory bowel disease is plagued by high costs, potential side effects, and variable levels effectiveness. Fecal microbial transplant in diseases can offer an alternative to traditionally developed pharmacologic has demonstrated the ability induce remission randomized control trials. However, questions remain about ultimate role this therapy management, including long term safety, optimal composition transplanted stool.
Abstract Crohn’s disease (CD) patients who undergo ileocolonic resection (ICR) typically have recurrence at the anastomosis which has been linked with a gut dysbiosis. The aims of this study were to define mucosa-associated microbiota time ICR and determine if microbial community structure surgery was predictive future relapse. Ileal biopsies obtained after 6 months from CD subjects undergoing ICR. Composition function mucosal-associated assessed by 16S rRNA sequencing PICRUSt analysis....
Clostridium difficile is emerging as a major infectious disease threat worldwide. The incidence of C. infection (CDI) has exponentially increased globally, and the profile patients at risk changed in past decade.[1][1] Severe CDI outbreaks due to new, hypervirulent strains have
Ileocolic resection (ICR) is the most common intestinal performed for Crohn's disease, with recurrences commonly occurring at site of anastomosis. This study used an animal model ICR in wild-type mice to examine immunologic changes that developed around surgical anastomosis and how these impacted gut responses minor acute injury. was adult 129S1/SvlmJ results compared receiving sham or no surgery. Dextran sodium sulfate given either on post-operative day 9 24 evaluate immune intestine both...
Background: Gastrointestinal surgery imparts dramatic and lasting imbalances, or dysbiosis, to the composition of finely tuned microbial ecosystems. The aim present study was use a mouse ileocecal resection (ICR) model determine if tributyrin (TBT) supplementation could prevent onset dysbiosis alternatively enhance recovery gut microbiota reduce gastrointestinal inflammation. Methods: Male wild-type (129 s1/SvlmJ) mice aged 8–15 weeks were separated into single cages randomized 1:1:1:1 each...
Recurrence following abdominal surgery in Crohn disease is over 50%. The impact of genetics on postoperative recurrence not well defined.A literature search was conducted where inclusion required an assessment, by genotype, recurrence. primary endpoint odds surgical recurrence.Twenty-eight studies identified a total 6715 patients. Thirteen loci were as modifying the risk NOD2 factor for multiple works (cumulative ratio: 1.64, P = 0.003).A allele associated with disease. Progress this area...