A5061253151- Antibiotics Pharmacokinetics and Efficacy
- Neonatal and Maternal Infections
- Vascular Malformations and Hemangiomas
- Pharmaceutical studies and practices
- Neonatal Health and Biochemistry
- Vascular Anomalies and Treatments
- Pneumonia and Respiratory Infections
- Childhood Cancer Survivors' Quality of Life
- Drug Transport and Resistance Mechanisms
- Poisoning and overdose treatments
- Renal function and acid-base balance
- Antimicrobial Resistance in Staphylococcus
- Central Venous Catheters and Hemodialysis
- Mitochondrial Function and Pathology
- Cerebrospinal fluid and hydrocephalus
- Hemoglobinopathies and Related Disorders
- Lymphatic Disorders and Treatments
- Vascular anomalies and interventions
- Erythrocyte Function and Pathophysiology
- Intestinal and Peritoneal Adhesions
- Vascular Malformations Diagnosis and Treatment
- Iron Metabolism and Disorders
- Neonatal Respiratory Health Research
Tartu University Hospital
2012-2024
Prolonged infusion of meropenem has been suggested in studies with population pharmacokinetic modeling but not tested neonates. We compared the steady-state pharmacokinetics (PK) given as a short (30-min) or prolonged (4-h) to very-low-birth-weight (gestational age, <32 weeks; birth weight, <1,200 g) neonates define appropriate dosing regimen for phase 3 efficacy study. Short (n = 9) 10) infusions were at dose 20 mg/kg every 12 h. Immediately before and 0.5, 1.5, 4, 8, h after 4th 7th doses...
Despite differences in types of infection and causative organisms, pharmacokinetic-pharmacodynamic (PKPD) targets vancomycin therapy derived from adult studies are suggested for neonates. We aimed to identify doses needed the attainment AUC/MIC > 400 300 neonates with sepsis correlate these recommended treatment outcome. Neonates who had Vancomycin therapeutic drug monitoring (TDM) performed between January 1, 2010 December 31, 2012 were studied. Clinical characteristics, episodes...
ABSTRACT Group B streptococci are common causative agents of early-onset neonatal sepsis (EOS). Pharmacokinetic (PK) data for penicillin G have been described extremely preterm neonates but poorly late-preterm and term neonates. Thus, evidence-based dosing recommendations lacking. We describe the PK in with a gestational age (GA) ≥32 weeks postnatal <72 h. Penicillin was administered intravenously at dose 25,000 or 50,000 IU/kg body weight every 12 h (q12h). At steady state, blood samples...
Ampicillin is 1 of the most commonly used antibiotics for treatment early onset sepsis, but its pharmacokinetics (PK) poorly characterized. We aimed to define dose ampicillin late preterm and term neonates by evaluating PK in serum, cerebrospinal (CSF), epithelial lining fluid.A prospective study included receiving suspected or proven sepsis pneumonia. samples were collected at steady state, predose 5 minutes, hour, 3 hours, 8 12 hours after 3-minute infusion. concentrations measured...
Key Clinical Message Treatment of congenital chyloperitoneum is a challenge. Conservative methods may be ineffective. Preoperative visualization the site lymphatic leakage crucial, but radiological imaging technically complicated and not provide sufficient information, especially in small patients. To ease detection during surgery, preoperative feeding with fat‐rich formula Sudan Black has been recommended. However, administration result life‐threatening methemoglobinemia liver damage...
Retroperitoneal arteriovenous malformations (AVMs) are rare lesions consisting of dysplastic vessels, which may produce diverse clinical features. We report a case premature neonate born on the 29th week gestation, who presented with heart failure, generalized edema, respiratory dyspnea and metabolic acidosis. Digital subtraction angiography revealed large AVM located adjacent to aorta inferior vena cava. Lumbar arteries supplying were occluded by coils. The was partially embolized using...
Aims C‐reactive protein (CRP) is used to determine the effect of antibiotic treatment on sepsis in neonates/infants. We aimed develop pharmacokinetic–pharmacodynamic (PKPD) model meropenem and CRP neonates/infants evaluate its predictive performance dynamics. Methods Data from treated with 3 previous studies were analysed. To previously developed PK models, addition turnover, transit or compartment, delay differential equation PD models as a function concentration cumulative area under curve...
Arteriovenoosne malformatsioon (AVM) on harva esinev arenguanomaalia, mis koosneb dusplastiliste arterite ja veenide vorgustikust. Kirjandusest voib leida vaid uksikuid haigusjuhtude kirjeldusi retroperitoneaalruumi magistraalveresooni haaravate AVMide kohta. Artiklis kirjeldatud haigusjuhtu, kus enneaegsena sundinud lapsel tekkisid valjendunud sudamepuudulikkus, anasarka, respiratoorne duspnoe metaboolne atsidoos. Angiograafial tuvastati AVM lumbaalsete toitearteritega vargussundroomiga...
3aastasel ageda lumfoblastleukeemia ja 5aastasel osteomueliidi ning septilise sokiga lapsel tekkisid pohihaiguse ravikuuri ajal teadvushaired krambid, mille pohjuseks oli posterioorse reversiibelse entsefalopaatia sundroom (PRES). PRES on tanapaeval sagenev tusistus kriitiliselt haigete, eriti leukeemiaga laste induktsioonravil. Soodustavaks teguriks neurotoksilise seisundi valjakujunemisel voib olla arteriaalne hupertensioon voi neerupuudulikkus. Nuudisaegsed neuroradioloogia meetodid...
K-vitamiini kui olulise koagulatsiooni komponendi defi tsiit voib pohjustada spontaanseid eluohtlikke hemorraagiaid. Koikidel vastsundinutel esineb sunnil suhteline puudulikkus, mille tottu lastele manustatakse profulaktiliselt sunni jarel K-vitamiini. defitsiidi kliiniliseks valjenduseks on verejooksud. Arvestades lapse vanust verejooksu tekkimise ajal, jaotatakse tsiidist pohjustatud verejooks kolmeks alatuubiks: varane, klassikaline ning hiline vorm. Hilised tusistused harvad....
Neonataalne hemokromotoos on harva esinev halva prognoosiga raualadestushaigus. Raua ladestumine loote organismi algab umbes 24. rasedusnadalal. Rasedus voib sel puhul loppeda surma, enneaegsuse voi arengupeetusega. Edasine haiguse kulg progresseeruv ja lopeb sageli surmaga. Nuudisaegse meditsiini kasutuses ei ole voimalusi avastamiseks looteeas. Vastsundinul avaldub haigus hemor- raagilise raske maksa puudulikkuse sundroomina. Haiguse etioloogia loplikult selge. mooduka valjendusastme...