Hypoxia-inducible factor-1 alpha (HIF-1α) plays a key role in the cellular response to hypoxia, which crucial induction of abnormal angiogenesis and metastasis. Understanding mechanism for regulation by HIF-1α-regulating miRNA will contribute developing strategy prevent We conducted functional screening HIF-1α-inhibiting miRNAs evaluating effects mimics on HIF-1α expression identified miR-5586-5p as an inhibitor through mechanistic study. Angiogenic activity was assessed tube formation...

Cerebral Flow Autoregulation (CFA) is the dynamic process by which cerebral blood flow maintained within physiologically acceptable bounds during fluctuations of perfusion pressure. The distinction made with "static" autoregulation under steady-state conditions pressure, described celebrated "autoregulatory curve" a homeostatic plateau. This paper studies CFA changes in attains critical clinical importance patients stroke, traumatic brain injury and neurodegenerative disease cerebrovascular...

Insulation resistance degradation of dielectric BaTiO3 is expected to be closely correlated its defect structure frozen in from elevated processing temperatures. For BaTiO3, respectively doped with variable-valence (MnTi) and fixed-valence acceptors (AlTi), their structures were by quenching at different equilibrium oxygen activities the range −18 < log aO2≤ 0 1000 900 °C, respectively, electrical conductivities measured against temperature 200 ≤T/K ≤ 494 impedance spectroscopy. Frozen-in...

In order to examine the effect of changes in heart rate (HR) upon cerebral perfusion and autoregulation, we include HR signal recorded from 18 control subjects as a third input two-input model haemodynamics that has been used previously quantify dynamic effects arterial blood pressure end-tidal CO2upon flow velocity (CBFV) measured at middle arteries via transcranial Doppler ultrasound. It is shown inclusion reduces output prediction error statistically significant manner, which implies...

In this paper, we are interested in soft tissue differentiation by multiband images obtained from the High-Resolution Ultrasonic Transmission Tomography (HUTT) system using a spectral target detection method based on constrained energy minimization (CEM). We have developed new (called "CEM filter bank") consisting of multiple CEM filters specially designed for detecting types tissues. Statistical inference output bank is used to make decision maximum statistical significance rather than...

Recent efforts to understand the anisotropic oxide ion conduction mechanism in apatite-type La9.33+x(SiO4)6O2+3x/2 (−0.5 ≤ x 1.25) by sophisticated structural investigation and atomistic simulations could not definitely be corroborated nor refuted experimental conductivity measurements, since no measurements on single crystalline lanthanum silicates are available. In present work strong frequency dispersions bulk impedance of polycrystalline were successfully described a hierarchical ladder...

A new higher order statistics-based adaptive interference canceler is introduced to mitigate narrowband and wideband interferences in environments where the non-Gaussian a reference signal, which highly correlated with interference, available. The scheme uses statistics (HOS) of primary inputs employs gradient-type algorithm for updating filter coefficients. update equation HOS-based independent uncorrelated Gaussian noises can more effectively than filters based on second-order statistics....

The reignition of the arc during interruption process deteriorates switching performance low-voltage devices (LVSDs). Avoiding is thus a key goal in effective design quenching chamber. A reliable evaluator provides opportunity to predict an LVSD and refine product prior manufacture empirical device testing. In this paper, evaluators are investigated through analysis test data for several types LVSDs under single-phase three-phase circuit conditions. It observed that ratio recovery voltage...

Enhanced switching performance during the interruption process is achieved when arc quickly enters and stays within splitter plate region with itself remaining attached to surface of plates. It well known that vent design in low-voltage devices (LVSDs) has a significant influence on motion an event: however, there been limited experimental studies correlating whole quenching chamber, including plates region, size distribution apertures, which are important for plasma flow LVSDs. This paper...

Arc modelling is one of the most effective tools to evaluate switching performance low-voltage devices (LVSDs), reducing testing requirements real devices; however, there still a limitation on ability predict re-ignition. It has been shown that re-ignition in LVSDs strongly dependent exit arc voltage (the value just prior current zero point) and ratio recovery at point. In order reliably, it necessary improve from modelling.In previous studies splitter plates, relationship between potential...

The complex ambiguity function based on second-order statistics (CAF-SOS) has been used to simultaneously estimate the frequency-delay of arrival (FDOA) and time-delay (TDOA) between two signal measurements; its performance, however, is sensitive correlation additive noise sources. When sources are assumed be Gaussian, we develop a new higher order (CAF-HOS) that reduces unknown noise-correlation effect. CAF-HOS algorithm utilizes nonstationary cross cumulant estimates their Fourier...

This paper presents a novel segmentation methodology for automated classification and differentiation of soft tissues using multiband data obtained with the newly developed system high-resolution ultrasonic transmission tomography (HUTT) imaging biological organs. extends combines two existing approaches: L-level set active contour (AC) approach agglomerative hierarchical k-means unsupervised clustering (UC). To prevent trapping current iterative minimization AC algorithm in local minimum,...

This paper presents a general methodology for the optimal design of stimulation patterns applied to neuronal ensembles in order elicit desired effect. The follows variant hierarchical Volterra modeling approach that utilizes input-output data construct predictive models describe effects interactions among multiple input events an ascending interaction complexity. illustrative example presented this concerns multi-unit activity CA1 neurons hippocampus rodent performing learned...

We present a novel methodology for modeling the interactions between neuronal ensembles that utilizes concept of Principal Dynamic Modes (PDM) and their associated nonlinear functions (ANF). This new approach seeks to reduce complexity multi-input/multi-output (MIMO) model - an issue critical practical importance in scaling up MIMO models incorporate hundreds (or even thousands) input-output neurons. Global PDMs were extracted from data using estimated first-order second-order kernels...

Anatomical and physiological evidence showing reciprocal connectivity between the hippocampus Entorhinal Cortex, suggest that in tandem, they function as a closed-loop system. Using neuronal data recorded from rodent hippocampal regions CA3 CA1, we construct two open-loop input-output nonlinear dynamical models of neural signal transformations to CA1 CA3, subsequently combine them into model. It was found model replicates theta delta rhythms experimental data, whereas do not, suggesting...

Purpose The purpose of this paper is to investigate a reliable evaluator arc re-ignition and develop numerical tool for accurate prediction behaviour low-voltage switching devices (LVSDs) prior empirical laboratory testing real products. Design/methodology/approach Two types interruption tests have been carried out in the investigation evaluators. Arc modelling coupled with load circuit has developed predict characteristics based on conventional magnetohydrodynamics theory, special attention...

Arc motion in a quenching chamber has significant influence on switching performance low voltage device (LVSD).A high-speed optical arc imaging system (AIS) been used to investigate the of design parameters motion.Arc light intensity is transmitted photodiodes AIS through fibres during process.The and associated software enable detailed be tracked inside at an image sampling rate 1 MHz.Since higher temperature leads greater radiation, it assumed that measured by related temperature.However,...