A5077081028- Axial and Atropisomeric Chirality Synthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organometallic Complex Synthesis and Catalysis
- Synthesis and Reactivity of Heterocycles
- Alkaloids: synthesis and pharmacology
- Synthesis of Indole Derivatives
- Coordination Chemistry and Organometallics
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Magnetism in coordination complexes
- Genetics, Bioinformatics, and Biomedical Research
- Radiomics and Machine Learning in Medical Imaging
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Crystallography and molecular interactions
- Molecular spectroscopy and chirality
- AI in cancer detection
- Asymmetric Synthesis and Catalysis
Boston University
2018
University of North Carolina at Charlotte
2013-2017
Asymmetric synthesis of the biologically active xanthone dimer griffipavixanthone is reported along with its absolute stereochemistry determination. Synthesis natural product accomplished via dimerization a p-quinone methide using chiral phosphoric acid catalyst to afford protected precursor in excellent diastereo- and enantioselectivity. Mechanistic studies, including an unbiased computational investigation ion-pairs parallel tempering, were performed order probe mode asymmetric induction.
Why is it π? The first X-ray crystal structure of a cuprate–carbonyl π-complex has been obtained for the intermediate prepared from Me2CuLi and fluorenone (see scheme). It also between an organocuprate double bond any kind. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising (other than missing files) should...
Isatoic anhydride is elaborated to water soluble bioconjugation reagents that gives functionality and solubility in one self-cleaning step. This new platform offers high atom economy with carbon dioxide being the only byproduct, shown very quickly efficiently label proteins bicarbonate buffered solutions.
Grow slow: The usual direct treatment of MeLi and CuSPh did not yield X-ray quality crystals MeCu(SPh)Li. An indirect method starting from Me2CuLi⋅LiSPh chalcone afforded the desired by slow reaction intermediate π-complex (see scheme). This strategy produced first crystal structure a Posner cuprate. A complementary NMR study showed that contact ion pair was also main species in solution. As service to our authors readers, this journal provides supporting information supplied authors. Such...
π! – aber wie? Die erste Röntgenkristallstruktur eines Cuprat-Carbonyl-π-Komplexes und überhaupt π-Komplexes aus einem Organocuprat einer Doppelbindung jedweder Art wurde für ein Intermediat der Reaktion von Me2CuLi mit Fluorenon erhalten (siehe Schema).
This release is mainly being created to have a DOI cite the software. should not be considered at all API stable.
Asymmetric synthesis of the biologically active xanthone dimer griffipavixanthone (GPX) is reported along with its absolute stereochemistry determination. Synthesis natural product accomplished <i>via</i> dimerization a <i>p-</i>quinone methide (<i>p-</i>QM) using chiral phosphoric acid (CPA) catalyst to afford protected precursor in excellent diastereo- and enantioselectivity. Mechanistic studies, including an unbiased computational investigation...
Asymmetric synthesis of the biologically active xanthone dimer griffipavixanthone (GPX) is reported along with its absolute stereochemistry determination. Synthesis natural product accomplished via dimerization a p- quinone methide ( QM) using chiral phosphoric acid (CPA) catalyst to afford protected precursor in excellent diastereo- and enantioselectivity. Mechanistic studies, including an unbiased computational investigation ion-pairs parallel tempering (PT), were performed order probe...