A5047495826- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Radiopharmaceutical Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical Synthesis and Analysis
- Organic Light-Emitting Diodes Research
- Crystal structures of chemical compounds
- Synthesis and biological activity
- Synthesis and properties of polymers
- Collagen: Extraction and Characterization
- Machine Learning in Materials Science
- Bioactive Compounds and Antitumor Agents
- Eicosanoids and Hypertension Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and Reactions of Organic Compounds
- Cancer therapeutics and mechanisms
- RNA and protein synthesis mechanisms
- Organometallic Compounds Synthesis and Characterization
- Solid-state spectroscopy and crystallography
- Supramolecular Chemistry and Complexes
- Enzyme Structure and Function
- Organic Electronics and Photovoltaics
- Covalent Organic Framework Applications
- Crystallography and molecular interactions
University of the Free State
2018-2024
Clinvet
2021
Metal-based complexes with their unique chemical properties, including multiple oxidation states, radio-nuclear capabilities and various coordination geometries yield value as potential pharmaceuticals. Understanding the interactions between metals biological systems will prove key for site-specific of new metal-based lead compounds. This study merges concepts target fragment-based drug methodologies, supported by varying anomalous scattering rhenium along infrared spectroscopy, has...
Abstract Direct mixing (de novo) and Solvent Assisted Ligand Exchange (SALE) are the main methods used for synthesis of Mixed-Linker Zeolitic Imidazolate Frameworks (ML-ZIFs). ML-ZIFs with combined –NO 2 –Br/–Cl functionalities were prepared via both synthetic routes. Thereafter CO uptake compared, as well their abilities to fixate epoxide substrates. The de novo resulted in SOD topologies, 60: 40 (–NO : –Br/–Cl) functionality ratios, higher porosities, better thermal stability than...
The retention of the covalent binding an organometalllic rhenium complex to a protein at physiological body temperature (37 °C) is described and compared related 100 K crystal structure.
A series of seven fac-[Re(CO)3(5Me-Sal-Trypt)(L)] complexes containing tryptamine on the N,O 5-methyl-salicylidene bidentate ligand backbone and where L is MeOH, Py, Imi, DMAP, PPh3 coordinated to 6th position have been studied, including formation a dinuclear Re2 cluster. The crystallographic solid state structures show marked similarity in structural tendency, particular rigidity Re core hydrogen bond interactions similar those found protein structures. rates stability were evaluated by...
Abstract C 10 H 11 NO 2 , monoclinic, P 1 / n (no. 14), a = 3.7617(3) Å, b 12.9267(10) c 23.4609(17) β 92.337(3)°, V 1139.87(15) Å 3 Z 4, R gt ( F ) 0.0413, wR ref 0.1071, T 100 K.
Nucleation of collagen-fold formation has been followed by D-H exchange techniques coupled with infra-red measurements the Arnide II absorbance at 1550 cm-'. Solution Sephadex and thin film were applied to two gelatin fractions differing in molecular weight chain cross-linking. The rate was measured temperatures, T above below melting temperature, TM. At T> TM classes exchangeable H detected. On basis their pD-rate profiles, these assigned pyrollidine ring rich sequences t o deficient...
Abstract C 13 H 10 O 6 N 3 Re, monoclinic, P 2 1 / c (no. 14), a = 7.9325(9) Å, b 13.811(2) 13.458(2) β 92.637(4)°, V 1472.83(4) Å , Z 4, R gt ( F ) 0.0249, wR ref 0.0568, T 100(2) K. CCDC no. : 2024932
Crystal packing of several halogenated alanine derivatives was investigated using the combined analysis short atom–atom contacts and energy framework patterns.
Abstract C 19 H 31 AgN 6 O 3 P 2 , monoclinic, 1 / c (no. 14), a = 16.5661(8) Å, b 6.1644(3) 23.8822(10) β 114.553(3)°, V 2218.32(18) Å Z 4, R gt ( F ) 0.0188, wR ref 0.0525, T 100(2) K.