A5052107571- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Antioxidant Activity and Oxidative Stress
- Endoplasmic Reticulum Stress and Disease
- Cytokine Signaling Pathways and Interactions
- Nicotinic Acetylcholine Receptors Study
- Estrogen and related hormone effects
- Cynara cardunculus studies
- Natural Compound Pharmacology Studies
- Phytase and its Applications
- Effects and risks of endocrine disrupting chemicals
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Synthesis and Biological Evaluation
- Drug Transport and Resistance Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Cancer, Stress, Anesthesia, and Immune Response
- Liver Diseases and Immunity
- RNA regulation and disease
- Lung Cancer Treatments and Mutations
- Inflammatory mediators and NSAID effects
- Cholesterol and Lipid Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Retinoids in leukemia and cellular processes
- Biological Activity of Diterpenoids and Biflavonoids
University of Teramo
2024-2025
Sapienza University of Rome
2021-2025
A combination of anticancer drugs and chemosensitizing agents has been approached as a promising strategy to potentiate chemotherapy reduce toxicity in aggressive chemoresistant cancers, like hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), pancreatic ductal adenocarcinoma (PDAC). In the present study, ability caryophyllane sesquiterpenes sorafenib efficacy was studied HCC, CCA, PDAC cell models, focusing on modulation STAT3 signaling ABC transporters; tolerability studies normal...
The protein disulfide isomerase A3 (PDIA3) is directly or indirectly involved in various physiopathological processes and participates cancer initiation, progression chemosensitivity. However, little known about its involvement glioblastoma. To obtain specific information, we performed cellular experiments the T98G U-87 MG glioblastoma cell lines to evaluate role of PDIA3. loss PDIA3 functions, either through inhibition silencing, reduced cells spreading by triggering cytotoxic phenomena....
The β-isomer of hexachlorocyclohexane (β-HCH) is a globally widespread pollutant that embodies all the physicochemical characteristics organochlorine pesticides, constituting an environmental risk factor for wide range noncommunicable diseases. Previous in vitro studies from our group disclosed carcinogenic potential β-HCH, which contributes to neoplastic transformation by means multifaceted intracellular mechanisms. Considering positive evidence regarding protective role natural bioactive...
Organochlorine pesticides (OCPs) are a class of environmentally persistent and bioaccumulative pollutants. Among these, β-hexachlorocyclohexane (β-HCH) is byproduct lindane synthesis, one the most worldwide widespread pesticides. β-HCH cellular mechanisms inducing chemical carcinogenesis correspond to many those chemoresistance, in particular, by activation signal transducer activator transcription 3 (STAT3) signaling pathways. For this purpose, four cell lines, representative breast, lung,...
Organochlorine pesticides constitute the majority of total environmental pollutants, and a wide range compounds have been found to be carcinogenic humans. Among all, growing interest has focused on β-hexachlorocyclohexane (β-HCH), virtually most hazardous and, at same time, poorly investigated member hexachlorocyclohexane family. Considering multifaceted biochemical activities β-HCH, already established in our previous studies, aim this work is assess whether β-HCH could also trigger...
Exposure to cigarette smoke (CS) has been associated with an increased risk of fatal breast cancers and recurrence, along chemoresistance chemotherapy impairment. This strengthens the interest in chemopreventive agents be exploited both healthy oncological subjects prevent or repair CS damage. In present study, we evaluated properties natural sesquiterpene β-caryophyllene towards damage induced by condensate (CSC) triple negative cancer MDA-MB-468 cells. Particularly, assessed ability...
In a previous work, it was shown that punicalagin, an active ingredient of pomegranate, is able to bind PDIA3 and inhibit its disulfide reductase activity. Here we provide evidence punicalagin can also PDIA1, the main expressed form protein isomerase (PDI). this comparative study, affinity effect binding on each were evaluated, computational approach used identify putative sites. Punicalagin binds either PDIA1 or with similar affinity, but inhibition efficacy activity higher for PDIA3....
PDIA3 is a pleiotropic protein primarily located in the endoplasmic reticulum where it involved folding, catalyzing formation, breakage, and rearrangement of disulfide bonds. implicated numerous pathologies such as cancer, inflammation, neurodegeneration. Although punicalagin has been proven to be highly promising inhibitor can used target glioblastoma, does not have sufficient selectivity for quite-large molecule. With aim finding derivatives with simplified structure, we selected...