A5079123795- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Electrolyte and hormonal disorders
- Digital Communication and Language
- Medicinal Plants and Neuroprotection
- Restless Legs Syndrome Research
- Media and Digital Communication
- Genetics and Neurodevelopmental Disorders
- Translation Studies and Practices
- Rhetoric and Communication Studies
- Literature, Culture, and Aesthetics
- Political Systems and Governance
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Liver Diseases and Immunity
- Media Studies and Communication
- Autism Spectrum Disorder Research
Sapienza University of Rome
2017-2024
University of Verona
2024
University of Milano-Bicocca
2022-2024
University of Milan
2022-2024
European University of Rome
2022
Neuroglial cells that provide homeostatic support and form defence of the nervous system contribute to all neurological disorders. We analyzed three major types neuroglia, astrocytes, oligodendrocytes, microglia in brains an animal model autism spectrum disorder, which rats were exposed prenatally antiepileptic mood stabilizer drug valproic acid; this being acknowledged clinical relevance. tested autistic-like behaviors acid-prenatally male by performing isolation-induced ultrasonic...
Abstract In an aging society, Alzheimer’s disease (AD) exerts increasingly serious health and economic burden. Current treatments provide inadequate symptomatic relief as several distinct pathological processes are thought to underlie the decline of cognitive neural function seen in AD. This suggests that efficacy treatment requires a multitargeted approach. this context, palmitoylethanolamide (PEA) provides novel potential adjunct therapy can be incorporated into strategy. We used young...
Stress represents a major risk factor for psychiatric disorders, including post-traumatic stress disorder (PTSD). Recently, we dissected the destabilizing effects of acute on excitatory glutamate system in prefrontal cortex (PFC). Here, assessed single subanesthetic administration ketamine (10 mg/kg) transmission and dendritic arborization PFC footshock (FS)-stressed rats, along with changes depressive, anxious, fear extinction behaviors. We found that ketamine, while inducing mild increase...
Abstract Stress affects the brain and alters its neuroarchitecture function; these changes can be severe lead to psychiatric disorders. Recent evidence suggests that astrocytes microglia play an essential role in stress response by contributing maintenance of cerebral homeostasis. These cells respond rapidly all stimuli reach brain, including stressors. Here, we used a recently validated rodent model post-traumatic disorder which rats categorized as resilient or vulnerable after acute...
Alzheimer's disease (AD) is a neurodegenerative disorder responsible for the majority of dementia cases in elderly people. It widely accepted that main hallmarks AD are not only senile plaques and neurofibrillary tangles but also reactive astrogliosis, which often precedes detrimental deposits neuronal atrophy. Such phenomenon facilitates regeneration neural networks; however, under some circumstances, like AD, astrogliosis detrimental, depriving neurons homeostatic support, thus...
Old age is a risk factor for Alzheimer's disease (AD), which characterized by hippocampal impairment together with substantial changes in glial cell functions. Are these alterations due to the progression or are they consequence of aging? To start addressing this issue, we studied expression specific astrocytic and microglial structural functional proteins validated transgenic model AD (3×Tg-AD). These mice develop both amyloid plaques neurofibrillary tangles, initial signs AD-like pathology...
Abstract Stress represents a main risk factor for psychiatric disorders. Whereas it is known that even single trauma may induce disorders in humans, the mechanisms of vulnerability to acute stressors have been little investigated. In this study, we generated new animal model resilience/vulnerability footshock (FS) stress rats and analyzed early functional, molecular, morphological determinants at tripartite glutamate synapses prefrontal cortex (PFC). We found adult male subjected FS can be...
Autoantibodies directed against the GluA3 subunit (anti-GluA3 hIgGs) of AMPA receptors have been identified in 20%–25% patients with frontotemporal lobar degeneration (FTLD). Data from and vitro/ex vivo pre-clinical studies indicate that anti-GluA3 hIgGs negatively affect glutamatergic neurotransmission. However, whether how chronic presence triggers synaptic dysfunctions appearance FTLD-related neuropathological behavioural signature has not clarified yet. To address this question, we...
Background: At the earliest stage of Alzheimer’s disease (AD), although patients are still asymptomatic, cerebral alterations have already been triggered. In addition to beta amyloid (Aβ) accumulation, both glial and neuroinflammation documented at this stage. Starting treatment prodromal AD could be a valuable therapeutic strategy. requires long-term care; therefore, only compounds with high safety profile can used, such as new formulation containing palmitoylethanolamide luteolin (co-ultra...
Oligodendrocytes are cells fundamental for brain functions as they form the myelin sheath and feed axons. They perform these critical thanks to cooperation with other glial cells, mainly astrocytes. The astrocyte/oligodendrocyte crosstalk needs numerous mediators receptors, such peroxisome proliferator-activated receptors (PPARs). PPAR agonists promote oligodendrocyte precursor (OPCs) maturation in myelinating oligodendrocytes. In Alzheimer’s disease brain, deposition of beta-amyloid (Aβ)...
A combination of anticancer drugs and chemosensitizing agents has been approached as a promising strategy to potentiate chemotherapy reduce toxicity in aggressive chemoresistant cancers, like hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), pancreatic ductal adenocarcinoma (PDAC). In the present study, ability caryophyllane sesquiterpenes sorafenib efficacy was studied HCC, CCA, PDAC cell models, focusing on modulation STAT3 signaling ABC transporters; tolerability studies normal...
Neuroinflammation is part of the complex immune response within central nervous system (CNS), whose details have been partially elucidated. The CNS involves elements carried from periphery and resident elements, mainly represented by glial cells. These cells drive neuroinflammation, which can be roughly defined as an articulated physiological characterized production a plethora inflammatory mediators that alter microenvironment. Growing evidence shows roles for neuroinflammation in aging...
<title>Abstract</title> Stress affects the brain and alters its neuroarchitecture function; these changes can be severe lead to psychiatric disorders. Recent evidence suggests that astrocytes microglia play an essential role in stress response by contributing maintenance of cerebral homeostasis. These cells respond rapidly all stimuli reaching brain, including stressors. Using a recently validated rodent model post-traumatic disorder allows rats classified as resilient or vulnerable after...
In this paper I intend to shed light on broadcast news interviews with a focus the increasing role of video-mediated platforms. To do so, first overview rules conduct journalists are required follow, pondering whether shift video-platforms has made substantial changes what recommended in manuals and posited scholarly studies. Then, illustrate corpus-based case study carried out by professional Chinese Russian diplomats. Similarities differences between face-to-face as well interviewees have...
Background: Alzheimer's disease (AD) is a serious health and economic challenge of the modern age. Current treatments provide only symptomatic relief, making necessary multitargeted approach against several pathological processes underlying such disease. In particular, beta-amyloid deposition, tauopathy, astrocyte dysfunction, neuroinflammation glutamate unbalance recently became promising targets to develop new therapies. this context, it has been shown that palmitoylethanolamide (PEA)...