A5082148417- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Animal Behavior and Welfare Studies
- Antibiotic Resistance in Bacteria
- Microbial infections and disease research
- Clostridium difficile and Clostridium perfringens research
- Zoonotic diseases and public health
- Animal Disease Management and Epidemiology
- Gut microbiota and health
- Vaccine Coverage and Hesitancy
- Mycobacterium research and diagnosis
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Rangeland Management and Livestock Ecology
- Salmonella and Campylobacter epidemiology
- Wildlife Ecology and Conservation
- Antimicrobial Peptides and Activities
- Insect and Pesticide Research
- Escherichia coli research studies
- Agricultural and Rural Development Research
- Pneumonia and Respiratory Infections
- Food Safety and Hygiene
- Probiotics and Fermented Foods
Food and Agriculture Organization of the United Nations
2019-2023
Utrecht University
2013-2020
BackgroundExtended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC), plasmid-mediated AmpC-producing E (pAmpC-EC), and other bacteria are resistant to important β-lactam antibiotics. ESBL-EC pAmpC-EC increasingly reported in animals, food, the environment, community-acquired health-care-associated human infections. These infections usually preceded by asymptomatic carriage, for which attributions animal, environmental, sources remain unquantified.MethodsIn this population-based...
In recent years, ESBL/AmpC-producing Escherichia coli (ESBL/AmpC-EC) have been isolated with increasing frequency from animals, food, environmental sources and humans. With incomplete scattered evidence, the contribution to human carriage burden these reservoirs remains unclear.To quantify molecular similarities between different as a first step towards risk attribution.Pooled data on ESBL/AmpC-EC isolates were recovered 35 studies in Netherlands comprising >27 000 samples, mostly obtained...
The nutritional and economic potentials of livestock systems are compromised by the emergence spread antimicrobial resistance. A major driver resistance is misuse abuse drugs. likelihood may be elevated in low- middle-income countries where limited professional veterinary services inadequately controlled access to drugs assumed promote non-prudent practices (e.g., self-administration drugs). extent these practices, as well knowledge attitudes motivating them, largely unknown within most...
To quantify associations between antimicrobial use and acquired resistance in indicator Escherichia coli over a period of time which involved sector-wide reductions broilers pigs (years 2004-14), veal calves (2007-14) dairy cattle (2005-14). Prevalence estimates were predicted for hypothetical further decrease use.Data reported annually the surveillance programme Netherlands retrieved. Two multivariate random-effects logistic models per animal sector used to relate total class-specific (as...
Abstract Since the establishment of a Global Action Plan (GAP) on Antimicrobial Resistance (AMR) (68th World Health Assembly, Geneva, Switzerland, 2015), most members Organisation (WHO) have developed and implemented National (NAP) based “One Health” approach to AMR. Aquaculture, significant among food producing sectors, has often been overlooked in AMR governance. We did systematic review 95 country NAPs assessed inclusion aquaculture. also reviewed scientific literature from 1996 until...
Previous studies in food-producing animals have shown associations between antimicrobial use (AMU) and resistance (AMR) specifically isolated bacterial species. Multi-country data are scarce only describe between-country differences. Here we investigate the pig faecal mobile resistome characteristics at farm-level across Europe.A cross-sectional study was conducted among 176 conventional farms from nine European countries. Twenty-five samples fattening pigs were pooled per farm acquired...
The presence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) in food animals is a public health concern. This study aimed to determine prevalence ESBL-E. on pig farms and assess the effect reducing veterinary antimicrobial use (AMU) farm management practices occurrence farms. During 2011-2013, 36 Dutch conventional participated longitudinal (4 sampling times 18 months). Rectal swabs were taken from 60 pigs per pooled 6 within same age category. Presence was...
To determine associations between farm- and flock-level antimicrobial usage (AMU), farm biosecurity status the abundance of faecal resistance genes (ARGs) on broiler farms.In cross-sectional pan-European EFFORT study, conventional farms were visited faeces, AMU information records collected. The resistomes pooled samples determined by metagenomic analysis for 176 farms. A meta-analysis approach was used to relate total class-specific ARGs (expressed as fragments per kb reference million...
The poultry sector contributes significantly to Kenya’s food and economic security. This contribution is expected rise dramatically with a growing population, urbanization, preferences for animal-source foods. Antimicrobial resistance putting the in Kenya—and worldwide—at risk of production losses due failure medicines animal (and human) health. emergence spread antimicrobial has been linked overuse misuse antimicrobials other sectors. Previous studies have documented farmer use but without...
The farming community can be a vehicle for introduction of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in hospitals. During 2011-2013, an 18-month longitudinal study aimed at reducing the prevalence LA-MRSA was conducted on 36 pig farms Netherlands. Evaluations every 6 months showed slight decrease MRSA animals and stable farmers family members. Antimicrobial use, expressed as defined daily dosages per animal year, decreased 44% during period associated with...
By studying the entire human faecal resistome and associated microbiome, diversity abundance of antimicrobial resistance genes (ARGs) can be comprehensively characterized. Prior culture-based studies have shown associations between occupational exposure to livestock carriage specific resistant bacteria. Using shotgun metagenomics, present study investigated 194 resistomes bacteriomes from humans occupationally exposed ARGs in (i.e. pig poultry farmers, employees family members slaughterhouse...
International organizations and governments have argued that animal health service providers can play a vital role in limiting antimicrobial resistance by promoting the prudent use of antimicrobials. However, there is little research on impact these at farm level, especially low- middle-income countries where enforcement prudent-use regulations limited. Here, we mixed-methods approach to assess how health-seeking practices layer farms Ghana (
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) emergence is a major public health concern. This study was aimed at assessing risk factors for persistently carrying MRSA in veal calf farmers and their family members. We also evaluate the dynamics of environmental load during veal-calf production cycle.Observational, longitudinal, repeated cross-sectional study.52 farms Netherlands.From end 2010 to 2011, total 211 farmers, members employees were included study.Nasal...
Animal health service providers can play an important role in limiting drug resistance by promoting responsible and prudent use of veterinary drugs. Recognizing this potential, international agencies governments have called for these to receive stewardship training, particularly low- middle-income countries where top-down regulations (e.g., national regulation prescriptions) are largely unfeasible. The success trainings promote will depend on many factors, including understanding how...
With the ultimate aim of containing emergence resistant bacteria, a Dutch policy was set in place 2010 promoting reduction antimicrobial use (AMU) food-producing animals. In this context, study evaluated strategies to curb livestock-associated methicillin Staphylococcus aureus (LA-MRSA). Fifty-one veal calf farms were assigned one 3 arms: RAB reducing antimicrobials by protocol; RAB-CD protocol and applying cleaning disinfection program; Control without interventions. MRSA carriage tested...
Chicken and pork are the most frequently consumed meat products in Philippines. Swine poultry reared either commercial farms (CMf) backyard (BYf); latter production system is relatively common essential to food security low-and middle income countries (LMICs) such as Similar resource limited LMICs, antimicrobial use (AMU) surveillance has not yet been established, thus AMU animals a knowledge gap understanding emergence of resistance (AMR) zoonotic foodborne bacteria country. This...
Global, national, and local efforts to limit antimicrobial resistance (AMR) often stress the importance of raising awareness among users, sellers, prescribers drugs. This emphasis is founded upon two assumptions. First, limited, particularly concerning links between use (AMU) AMR. Second, “filling gaps” will motivate practises that The first assumption supported by knowledge, attitudes, (KAP) surveys but these same studies provide mixed support for second, with several finding knowledge...
Abstract Objectives Slaughterhouse staff is occupationally exposed to antimicrobial resistant bacteria. Studies reported high resistance gene (ARG) abundances in slaughter pigs. This cross-sectional study investigated occupational exposure tetracycline (tetW) and macrolide (ermB) genes assessed determinants for faecal tetW ermB carriage among pig slaughterhouse workers. Methods During 2015–2016, 483 samples personal questionnaires were collected from workers a Dutch abattoir, together with...
Introduction Awareness-raising campaigns play a central role in efforts to combat drug resistance. These assume that knowledge deficits drive poor practices increase Therefore, increasing awareness will promote prudent and reduce However, most have been developed evaluated high-income public health settings. Consequently, it is not clear whether these are effective low-income middle-income countries and/or within animal Methods Focus group discussions in-depth interviews were used collect...
To assess the feasibility of Farmer Field School approach to address complex problem antimicrobial resistance in agriculture, specifically within small-to-medium-scale layer poultry systems Ghana and Kenya. Impact was assessed across three domains relevant emergence selection resistance, including infection, prevention, control practices, engagement with animal health professionals, knowledge, attitudes, practices on use resistance.Farmer Schools were held (N = 2) Kenya 3) an eight-month...
Abstract The nutritional and economic potentials of livestock systems are compromised by the emergence spread antimicrobial resistance. A major driver resistance is misuse abuse drugs. likelihood may be elevated in low- middle-income countries where limited professional veterinary services laissez faire access to drugs assumed promote non-prudent practices (e.g., self-administration drugs). extent these practices, as well knowledge attitudes motivating them, largely unknown within most...