A5085533756- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanopore and Nanochannel Transport Studies
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Cells and Metastasis
- Underwater Vehicles and Communication Systems
- Geophysical Methods and Applications
- Mathematical Biology Tumor Growth
- Soft Robotics and Applications
- Underwater Acoustics Research
- Image and Signal Denoising Methods
- Advanced Image Fusion Techniques
- Molecular Junctions and Nanostructures
- Cellular Mechanics and Interactions
- Cancer, Hypoxia, and Metabolism
- Microfluidic and Bio-sensing Technologies
- Advanced Image Processing Techniques
University of Washington
2022-2024
Seattle University
2022-2024
Infinia ML (United States)
2021
Naval Surface Warfare Center
2021
NSWC Panama City Division
2021
University of Arizona
2016
Applied Mathematics (United States)
2016
Cancer drug testing in animals is an extremely poor predictor of the drug's safety and efficacy observed humans. Hence there a pressing need for functional platforms that better predict traditional immunotherapy responses human, live tumor tissue or constructs, at same time are compatible with use mouse to facilitate building more accurate disease models. Since many cancer actions rely on mechanisms depend microenvironment (TME), such should also retain as much native TME possible....
ABSTRACT Functional assays on intact tumor biopsies can potentially complement and extend genomics-based approaches for precision oncology, drug testing, organs-on-chips cancer disease models by capturing key determinants of therapeutic response, such as tissue architecture, heterogeneity, the microenvironment. Currently, most these rely fluorescent labeling, a semi-quantitative method best suited to be single-time-point terminal assay or labor-intensive immunostaining analysis. Here, we...
Functional assays on intact tumor biopsies can complement genomics-based approaches for precision oncology, drug testing, and organs-on-chips cancer disease models by capturing key therapeutic response determinants, such as tissue architecture, heterogeneity, the microenvironment. Most of these rely fluorescent labeling, a semiquantitative method best suited single-time-point or labor-intensive immunostaining analysis. Here, we report integrated aptamer electrochemical sensors on-chip,...
This work demonstrates that automated mine countermeasure (MCM) tasks are greatly facilitated by characterizing the seafloor environment in which sensors operate as a first step within comprehensive strategy for how to exploit information from available sensors, multiple detector types, measured features, and target classifiers, depending on specific seabed characteristics present high-frequency synthetic aperture sonar (SAS) imagery used perform MCM tasks. approach is able adapt...
ABSTRACT Current cancer disease models fail to faithfully recapitulate key features of the human tumor microenvironment (TME), such as immune and vascular cells, while simultaneously enabling high-throughput drug tests. We have recently developed a precision slicing method that optimizes yield large numbers cuboidal microtissues (“cuboids”, ∼(400 µm) 3 ) from single biopsy. Here we demonstrate cuboids syngeneic mouse tumors retain complex TME, making them amenable for immunotherapy...
The scarcity of human biopsies available for drug testing is a paramount challenge developing new therapeutics, disease models, and personalized treatments. Microtechnologies that combine the microscale manipulation tissues fluids offer exciting possibility miniaturizing both models workflows on scarce biopsies. Unfortunately, these technologies presently require microfluidic devices or robotic dispensers are not widely accessible. We have rapidly-prototyped an inexpensive platform based...
In this paper, we introduce a new algorithm based on total variation for denoising speckle noise images.Total was introduced by Rudin, Osher, and Fatemi in 1992 regularizing images.Chambolle proposed faster the duality of convex functions minimizing variation, but his built Gaussian removal.Unlike noise, which is additive, multiplicative.We modify original Chambolle images using first equation denoising, Krissian, Kikinis, Westin Vosburgh 2005.We apply to Krissian et al. model develop images.
The microvasculature within the tumor microenvironment (TME) plays an essential role in cancer signaling beyond nutrient delivery. However, it has been challenging to control generation and/or maintenance of ex vivo systems, a critical step for establishing models high clinical biomimicry. There have great successes engineering tissues incorporating de novo (e.g., organoids and organs-on-chip), but these reconstituted are formed with non-native cellular molecular components that can skew...
ABSTRACT There is a pressing need for functional testing platforms that use human, live tumor tissue to better predict traditional and immunotherapy responses. Such should also retain as much of the native microenvironment (TME) possible, many cancer drug actions rely on TME-dependent mechanisms. Present high-throughput have some these features, e.g. based patient-derived organoids, require growth step alters TME. On other hand, micro-dissected “spheroids” an intact TME shown promising...